In October, researchers reported the first known case of partial
oseltamivir resistance in a 14 - year - old Vietnamese girl infected with H5N1.
The evolution of
oseltamivir resistance was therefore enabled by «permissive» mutations that allowed the virus to tolerate subsequent occurrences of H274Y.
The His274 → Tyr274 (H274Y) mutation confers
oseltamivir resistance on N1 influenza neuraminidase but had long been thought to compromise viral fitness.
Not exact matches
They describe virus strains with mutations known to confer high
resistance to
oseltamivir, which they isolated from a 13 - year old girl and a 35 - year old woman killed by H5N1.
The H5N1 avian influenza strain developed strong
resistance to
oseltamivir, better known as Tamiflu, in two Vietnamese patients who died from the virus early this year, according to a new study.
The strains in six other patients on
oseltamivir did not develop
resistance.
While adamantane
resistance mutations appeared readily, it took 15 - 38 years after FDA approval to emerge, but emerged 3 times, whereas, the less spontaneous
oseltamivir mutations took at most 7 years, serving as a public health cautionary tail.
Unnecessary use of anti-viral medications leads to
resistance within the influenza virus population so it is important that medications such as
oseltamivir not be used for infections which are not life - threatening in nature or which are likely to resolve with routine supportive care.