Sentences with word «ossification»

This bizarre shift of tissue systems, known as heterotopic ossification in most cases, can be brought on with spinal cord injury, amputation and even hip surgery.

The receptor is important for the process of endochondral ossification, in which the cartilage cells first proliferate, and are then replaced by bone tissue.

«Our study provides profound insight into the role of cellular hypoxia in FOP flare - ups and shows that cellular oxygen sensing through HIF - 1α is a critical regulator of the BMP pathway and heterotopic ossification in FOP,» Kaplan said.

Some dogs diagnosed with incomplete ossification of the humeral chondile are deemed to have elbow dysplasia.

This hardening process is called ossification and usually begins in the legs and inner ear.

I know of no evidence to support a separate center of ossification for the medial coronoid process.»

But premature complete ossification of the sutures is called craniosynostosis.

The current study showed that HIF - 1α inhibitors, specifically the cancer drug imatinib (Gleevec), the natural product apigenin, and the small molecule PX - 478, potently inhibit dysregulated BMP signaling induced by HIF - 1α in cells, as well as heterotopic ossification following tissue injury in a mouse model of FOP.

Even from before birth, the development of these parts is by endochondral ossification with bone replacing cartilage at hopefully a normal rate and manner.

The anconeal process sometimes grows as a separate ossification centre and it is usually recognised as such at around 70 days.

A diminutive perinate European Enantiornithes reveals an asynchronous ossification pattern in early birds.

Zeroing in on a display case in a museum, he sees a prehistoric hospital ward full of 10 - ton patients suffering from bone spurs, cysts, healed fractures, fusions, outgrowths, divots, unusual ossifications, noticeable asymmetries, or, in one notorious instance, a few cracks in a tyrannosaur's rib cage.

It knows it's preposterous and stereotyped into ossification and makes sport of that without being a jerk about it.

They also require intakes of minerals and vitamins suited to their requirements to ensure a good ossification of the skeleton.

If there is injury to the growth plate, it can lead to malformation or improper ossification of the bone.

When ossification remains incomplete, it leaves the bone weak and vulnerable.

As a dog grows, cartilage is gradually replaced by bone, a process referred to as endochrondral ossification.

From about 12 to 20 weeks of age the medial coronoid process undergoes ossification (turning cartilage in bone).

During the first 10 weeks, the anconeal process is not visible on radiographs, but in the next couple of weeks, ossification begins, with gradual growth and increased opacity until, somewhere in the 16 - 24 week time frame, the center not only turns «completely» to bone, but also fuses with the ulna.

The result has been a startling ossification in the delivery of legal services.

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage - mediated inflammation in muscle.

The hardening process of the bones, called ossification, continues until puberty.

He reports that when Olsson «went to unaffected dogs, we could not find any evidence of a separate center of ossification for the medial coronoid.

Based on the CT based anatomical observations in probainognathians, it appears that the MSX2 gene underwent a significant change in its expression 240 - 246 million years ago and triggered the evolution of many typical mammalian traits including hair and whiskers, an enlarged cerebellum, complete ossification of the skull roof, and more importantly, the mammary glands, that define mammals today.

Rather, the coronoid ossifies (changes into bone tissue) from the embryo's cartilaginous part of the main ulnar shaft itself, without first passing through a separate ossification («bone center») itself.

English Springer Spaniels suffer from incomplete ossification of the bone located at the top of the elbow joint.

During birth and growth, this matrix is replaced at the epiphyses and metaphyses of long bones in a process called endochondral ossification.

Musculoskeletal — Elbow dysplasia, suspected incomplete ossification of the humeral condyles, complex fractures

«The ossification of men's fashion began at their feet.»

Directors whose skills do not support value creation; and ossification, complacency and atrophy more broadly, will also be targets.

His ossification is just about complete.

Practically all ossification is completed before your baby's birth, except the fontanels of the skull, which are the two soft spots on your baby's head.

The ossification process continues in your baby's bones and they are becoming harder.

Inside the body, the bones are continuing to get harder (ossification), and the skin is getting thicker.

I had believed he (Silver) would make a sincere effort to respond to the needs of our district, which has been long neglected, and unequally treated... Our district does not need a Speaker to represent us any longer — we have long seen the results a speaker can produce stagnation, fear, and ossification.

The sternum's ossification — a process in which the cartilage is replaced by bone — is a prerequisite to withstand the stresses of flight.

Individuals who experience severe injuries to their extremities, whether due to military combat or other trauma, often develop abnormal extra-skeletal bone in the damaged or healing tissue, a process known as heterotopic ossification (HO).

In the long run, better methods for stopping internal bleeding, more advanced regenerative, transplant and prosthetics technologies, and new drugs to prevent complications such as heterotopic ossification, are hoped to further improve care for DCBI patients.

The discussion also covers the management of common long - term complications such as heterotopic ossification, in which solid masses of bone begin growing inappropriately within soft tissues near blast injury sites, and the formation of blood clots in the extremities and lungs, which occurs at a high rate in DCBI survivors.

«Rapamycin treatment prevents crippling abnormal bone formation after severe limb injuries: Significant benefits seen after treatment with FDA - approved drug in rodent model of blast - related limb injury hold promise for first effective treatment to prevent trauma - induced heterotopic ossification (HO) formation.»

Another coauthor from Penn Medicine, Frederick S. Kaplan, MD, the Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine and Chief of the Division of Molecular Orthopaedic Medicine, is a world expert in heterotopic ossification (HO), the abnormal buildup of bone that occurs in FOP.