Sentences with phrase «osteoblast cells»

«Then osteoblast cells lay down new tissue.»

The WNT7B protein had no effect on the total activity of bone - degrading osteoclasts but substantially increased the number of bone - building osteoblast cells.

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

The murine osteoblast cell line 7F2 (ATCC) was cultured in α - MEM with 10 % FBS.

Whereas conditioned medium from ABL1 / ABL2 - depleted breast cancer cells did not affect RANKL abundance in osteoblasts compared with the cells treated with control conditioned medium (Fig. 5E), we found that conditioned medium from breast cancer cells lacking ABL kinases increased OPG abundance in the osteoblast cell line (Fig. 5F).

Not exact matches

Collagen peptides stimulate osteoblasts, which are the cells responsible for bone formation.

Ordinarily, bone is built up by cells called osteoblasts and reabsorbed during growth and healing by cells called osteoclasts.

The process takes place by means of a mechanism — unveiled in this study — that inhibits the activity of the osteoblasts, the cells that produce the bone matrix so that bones can grow during childhood and youth, and remain in good condition in adulthood.

A new therapy changes the balance of osteoblasts (pictured here) and fat cells in the bone marrow, leading to stronger bones.

Varghese and her team showed that they could control the differentiation of human pluripotent stem cells into functional osteoblasts — bone - building cells — simply by adding the molecule adenosine to their growth medium.

This work stems from a previous study by Varghese's group to understand how calcium phosphate minerals found in bone tissue induce stem cells to differentiate into osteoblasts.

Osteoblasts have more cytoskeleton than do adipocytes (fat cells).

Her team discovered that stem cells take up calcium phosphate to produce ATP, a metabolic molecule, which then breaks down into adenosine and signals the stem cells to become osteoblasts.

The parasites might trigger these problems, the scientists hypothesized, by upsetting the normal balance between cells known as osteoclasts, which dissolve bone, and cells called osteoblasts, which build it back up.

Instead, Sen found that actin was trafficked into the nuclei of the stem cells, where it had the surprising effect of inducing the cells to become osteoblasts.

Cells known as osteoblasts make new bone; other cells, osteoclasts, destroy old Cells known as osteoblasts make new bone; other cells, osteoclasts, destroy old cells, osteoclasts, destroy old bone.

To find out, Deb and his co-authors genetically tagged cardiac fibroblasts in mice and watched as they transitioned into bone - forming, osteoblast - like cells after heart injury.

Bones need a constant new creation of cells specific to their tissue, including the bone - producing cells called osteoblasts.

The progenitor cells for osteoblasts are bone marrow mesenchymal stem cells.

Two types of cell maintain bone: osteoblasts, which create new bone tissue, and osteoclasts, which remove old tissue.

«Clarifying the interplay between bone cells in bone remodeling: Spatiotemporal intercellular interactions between mature osteoblasts and mature osteoclasts in bone homeostasis in vivo demonstrated.»

The stretched cells turned into bone - making cells called osteoblasts, Chen's team reports in the April issue of Developmental Cell.

Therefore, it is important to understand the spatial - temporal relationship and interaction between osteoblasts and terminally differentiated osteocytes (bone cells) and osteoclasts in vivo.

THE METHODS In 2000, Gerard Karsenty, a molecular geneticist at Columbia University in New York City, discovered that leptin, a hormone made by fat cells, helps mold and repair the skeleton by acting upon bone - building cells called osteoblasts.

This soluble factor was found at higher levels in the blood of animals with lung tumors, could increase the activation of osteoblasts and contributed to the maturation of neutrophils in cultured cells.

«Our findings indicate the existence of long - distance interactions between lung tumors and bones: lung tumors remotely activate osteoblasts, and those bone cells, in turn, shape immunity by supplying tumors with cancer - promoting neutrophils,» says Pittet, who is an associate professor of Radiology at Harvard Medical School.

Furthermore, since the cells responsible for synthesising new bone tissue (osteoblasts) are known to attach close to the tip, it would appear that the electric field distribution signals this point as the centre of damage, becoming a moving beacon for repair efforts as the crack is healed.

Both the number and activity of osteoblasts — cells that produce and reshape bone tissue — were increased within the bone marrow of mice with lung tumors compared with cancer - free animals; and reducing the number of osteoblasts in mice not only limited neutrophil infiltration of tumors but also interrupted tumor progression.

Dissolved metal ions were shown to reach the bone marrow, where they impair mesenchymal stromal cells (MSCs), the progenitors of osteoblasts, a type of cell that is responsible for bone mineralization.

The researchers» investigations revealed that Del - 1 was expressed by at least three cell types in the bone marrow that support hematopoetic stem cells: endothelial cells, CAR cells and osteoblasts.

Two nearly identical plots showing cell counts after exposure to osteoblasts (bone cells) lacking a particular protein appear in Figure 6c of the Blood paper.

Proper bone development is maintained through a fine balance of bone - forming (osteoblast) and bone - resorbing (osteoclast) cells.

Then bone - making cells called osteoblasts and bone - absorbing cells called osteoclasts grow and sculpt new bone at the site of fracture.

«Our experiments showed that restoring H19 expression hindered by too much p53 restored «protective differentiation» of osteoblasts to counter events of tumor growth early on in bone cancer,» said co-author, Ihor Lemischka, PhD, Director of The Black Family Stem Cell Institute within the Icahn School of Medicine.

Too much p53 in bone - making cells called osteoblasts dials down a gene, H19, and a related protein, decorin, that would otherwise help stem cells mature (differentiate) to become normal osteoblasts.

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

Our bones are in a constant state of flux as the number of bone - making (osteoblast) cells fluctuates, while the number of bone - degrading (osteoclast) cells also adjusts.

Mesenchymal stem cells express a surface protein called α4β1 integrin as they turn into osteoblasts.

Osteoblasts, the cells that rebuild bone, are derived from mesenchymal stem cells.

Ovine cortical osteoblasts outperform bone marrow cells in an ectopic bone assay.

Interactions between human osteoblasts and prostate cancer cells in a novel 3D in vitro model.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

Mineralized human primary osteoblast matrices as a model system to analyse interactions of prostate cancer cells with the bone microenvironment.

This signaling pathway was found to be important in embryonic bone development (Wan et al., 2013), and in osteoblasts (bone cells) regulation (Glass et al., 2005; Harada & Rodan, 2003).

Differential osteogenicity of multiple donor - derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold - based 3D culture and in vivo.

Studying the drug - responsiveness of breast cancer cells cultured within human osteoblast - derived matrices.

We study cell (endothelial cells, fibroblasts, osteoblasts) guidance cues on biodegradable scaffolds (e.g. polymers).

Both pathways appear to be responsible for the differentiation and proliferation of cell type similar to bone mass and osteoblasts (Fig. 6).

Spatial Segregation of BMP / Smad Signaling Affects Osteoblast Differentiation in C2C12 Cells.

The periosteum is a mixed cell population of fibroblasts, osteoblasts, MSCs, and pericytes cells.