Thus, leptin determines the extent of bone formation by modulating, via sympathetic signaling,
osteoblast proliferation through two antagonistic pathways, one of which involves the molecular clock.
Partially antagonizing this inhibitory loop, leptin also upregulates AP - 1 gene expression, which promotes cyclin D1 expression,
osteoblast proliferation, and bone formation.
******* A similar trend was observed for genes involved in
osteoblast proliferation (Tgfb1, Fgfr2 and Pdgfa) and bone mineral metabolism (Col1a1, Col2a1, Col1a2 and Col11a1).
Not exact matches
Preliminary study on the adhesion and
proliferation of human
osteoblasts on starch - based scaffolds.
Both pathways appear to be responsible for the differentiation and
proliferation of cell type similar to bone mass and
osteoblasts (Fig. 6).
In vitro assays of the
osteoblast cultures derived from the MT1 - / - and MT2 - / - mice showed a cell intrinsic defect in the
proliferation, differentiation and mineralization abilities of MT2 - / -
osteoblasts compared to WT counterparts and the mutant cells did not respond to melatonin addition.
Muthusami S, Senthilkumar K, Vignesh C, Ilangovan R, Stanley J, Selvamurugan N, Srinivasan N. «Effects of Cissus quadrangularis on the
proliferation, differentiation and matrix mineralization of human
osteoblast like SaOS - 2 cells.»