Any region
of osteoblastic activity will be identified by this technique including osteoarthritis and infection.
F In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or
osteoblastic differentiation.
This causes
osteoblastic activity (osteoblasts are the cells within bone responsible for new bone growth), or in other words, the strain of the ligaments and tendons acting on the bone causes increased bone formation at those sites.
The present study demonstrated that cancer - secreted microRNAs
induced osteoblastic bone metastasis through promoting the osteogenic differentiation of bone - forming cells.
«When implanted into the tibia or onto the skull of mice, moreover, we discovered that cells expressing miR - 940 can induce the kind of
osteoblastic lesions that are typical of prostate cancer.»
Tumor cells metastasized to bone modify the activity of these cells and, depending on the type of cancer,
cause osteoblastic or osteolytic changes.
Tippelt, S., Ma, C., Witt, M., Bierbaum, S. and Funk, R.H. Collagen type I prevents glyoxal - induced apoptosis
in osteoblastic cells cultured on titanium alloy.
Interleukin (IL)-6 induction of osteoclast differentiation depends on IL - 6 receptors expressed
on osteoblastic cells but not on osteoclast progenitors
In addition to LOX - 1 mediated vascular inflammation, oxLDL / LOX -1 internalization triggers endothelial / vascular smooth muscle cell dysfunction, apoptosis, cellular senescence, or
osteoblastic differentiation.
If we can figure out how prostate cancer cells alter the environment inside bone to induce
this osteoblastic process, we can start to identify new therapeutic targets.»
In the bone metastatic microenvironment, the crosstalk between metastasized cancer cells and the surrounding bone cells is critical for the formation of
the osteoblastic or osteolytic phenotype.
The osteoblastic differentiation of these cells is manifested as «vascular calcification».
These include fibroblastic,
osteoblastic and finally, chondroblastic.
There are several types of dog bone tumors that fall under this definition including chondroblastic,
osteoblastic, fibroblastic, telangiectatic, and mixed type tumors.