Sentences with phrase «osteocalcin as»

«The addition of osteocalcin as a metabolic regulator may one day lead to novel therapies, but we need to understand much better how it works and how it fits into physiology before such therapies can be attempted in humans,» says endocrinologist Mitch Lazar, director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania.

His team are currently exploring the possibility of osteocalcin as a treatment option for infertile men.

Not exact matches

«What interested us was understanding how osteocalcin becomes active so as to be able to play its role when released into the blood.»

We naturally produce less osteocalcin throughout life as our bone mass declines.

Their stability makes osteocalcin more likely to endure warmer, harsher environments as well.

Serum osteocalcin was also quantified by ELISA (BT - 470; Biomedical Technologies, Stoughton, MA) following manufacturer instructions, as previously described (36).

As noted previously (12, 16), SED db / db mice in the current study had lower circulating osteocalcin levels than SED WT mice.

Regular weight - bearing exercise such as walking, running and weight - lifting can help counteract the bone weakening that comes with aging, and strong bones release a hormone called osteocalcin.

In the past few decades, scientists have realized that vitamin K2, menaquinone, is largely responsible for activating vitamin K - dependent proteins (VKDPs), such as osteocalcin and matrix Gla - protein.

As mentioned above, genetic or pharmaceutical interventions to increase or decrease bone resorption not only controlled the release of undercarboxylated osteocalcin, but also produced the expected effects on energy metabolism and testosterone.

If this paradigm is correct, one could argue that adequate vitamin K is needed to ensure that osteocalcin is fully carboxylated as it is produced, allowing it to accumulate in bone matrix, so that the presence of the undercarboxylated form in the bloodstream accurately reflects the degree of bone resorption.

Like MGP, osteocalcin is present, waiting to be activated, as early as the 1st trimester of pregnancy.

Osteocalcin also acts as a hormone to stimulate the pancreas to secrete insulin, as well as increasing insulin sensitivity (Vitamin K2 and the Calcium Paradox, pages 14, 123).

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However, in order to have these many effects in the body, osteocalcin must be activated to its carboxylated form by vitamin K - dependent proteins, known as matrix - GLA proteins, or MGPs.

The Opotowski team, which found that low vitamin A levels had as great an effect lowering BMD as did high vitamin A levels, suggested that vitamin A deficiency may contribute to increased fracture risk by allowing bone matrix to grow faster than it can be mineralized.12 Indeed, although the net effect of vitamin A is to stimulate osteoclasts and slow the growth of osteoblasts, vitamin A also causes osteoblasts to secrete a variety of enzymes and other proteins that are important to bone mineralization, including osteocalcin, which is a protein that plays a direct role in attracting and binding calcium within the bone matrix.6 By slowing the growth of the matrix but increasing the rate at which it is mineralized, adequate vitamin A helps to ensure sufficient bone density.

Bones One cup of boiled spinach provides over 1000 % of the RDA of vitamin K that can prevent excess activation of osteoclasts (the cells that break down bones), as well as promote the synthesis of osteocalcin, the protein that is essential for maintaining the strength and density of our bones.

In older, non diabetic men, three years of supplementation with 500 micrograms / day of vitamin K1 produced a significant reduction in insulin resistance compared with controls.43 And in a study of healthy young men, just four weeks of supplementation with 30 mg of K2 three times daily improved insulin sensitivity.44 This may have occurred as a result of an increase in the vitamin K - dependent Gla - protein osteocalcin, which has been shown in animal studies to increase insulin secretion and sensitivity.45