Sentences with word «osteoclast»

Maria Aranzazu Sanchez Fernandez (Pompe, TUD)-- «Role of osteoclasts in bone formation and bone microenvironment» (2008)

These findings support a role for ABL - mediated IL - 6 secretion by breast cancer cells in osteoclast activation through decreased OPG expression in osteoblasts.

Both MMP1 and IL - 6 have been linked to the regulation of osteoclast activation (32, 33), and depletion of TNC decreases breast cancer metastasis (49).

In the present study, the researchers focused on the role of MCP - 1 in PTH - induced osteoclast formation.

I think when there's absolute Growth hormone deficiency you may have an increase in osteoclast activity.

These findings suggest that ABL kinases promote tumor - induced osteoclast activation in part by increasing OPG abundance in osteoblasts.

Scientists suspected that steroids interfere with the process of bone remodeling, in which cells called osteoclasts continuously break down old bone while other cells called osteoblasts build new bone.

To get slightly more scientific in terms of bone health, an acidic environment has been shown to encourage the activity of osteoclast cells.

Like PTH, 1,25 - dihydroxyvitamin D stimulates the release of calcium from bone by activating osteoclasts (bone - resorbing cells).

As the tissue heals, the bone graft is resorbed by osteoclasts (bone - consuming cells), and is eventually replaced by natural, healthy bone tissue via osteoblasts (bone - building cells).

It's also purported to inhibit osteoclast formation that can cause bones to become porous and weak over time.

«First, cells known as osteoclasts remove old, weakened bone,» explains Andrea Singer, MD, clinical director of the NOF.

A series of experiments in the multiple myeloma study, with both animal models and cells from human patients, highlights the role of the transcription factor Runx2 to express bone - related genes in myeloma cells — genes that normally exist in bone residential cells, such as bone - forming osteoblasts and osteocytes, and the bone - resorbing osteoclast cells.

Increased osteoclast formation causes bones to become thinner and weaker.

That's how vitamin D cuts back on osteoclasts.

And they found that blood serum obtained following the consumption of an almond meal inhibits human osteoclast formation, function, and gene expression, providing direct evidence to support the association between regular almond consumption and a reduced risk of developing osteoporosis.

These findings suggest that ABL kinases regulate osteoclast maturation indirectly, possibly by modulating osteoblast function.

Inhibition of the IL - 6 receptor directly blocks osteoclast formation in vitro and in vivo (36).

Thus, depletion of the ABL kinases in breast cancer cells and the accompanying decrease in IL - 6 secretion result in enhanced OPG expression and reduced overall RANKL / OPG ratio, thereby decreasing osteoclast differentiation and bone destruction.

This indicates that microgravity's effect on bone density likely involves changes in mechanical force that lowers overall physical activity and therefore causes osteoclast activation

The team was surprised to find that B12 - deficient mice had only one - third of the normal number of bone - creating osteoblast cells, but had no change in bone - degrading osteoclast cells.

«Clarifying the interplay between bone cells in bone remodeling: Spatiotemporal intercellular interactions between mature osteoblasts and mature osteoclasts in bone homeostasis in vivo demonstrated.»

Addition of IL - 6 to reconstituted conditioned medium from ABL1 / ABL2 - depleted breast cancer cells partially restored osteoclast activation (Fig. 5, J and K).

Myeloma cells produce a substance which stimulates osteoclasts and results in a faster destruction of bone.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Don't osteoclasts «eat» only spent bone spicules that need to be removed, not healthy bone tissue?

But I don't think that there's any pituitary atrophy that takes place once you stop taking endogenous HGH so osteoclast activity should just stay being regulated by PTH and Estrogen levels.

But the MAOA enzyme triggers three proteins that enhance the function of the destructive osteoclasts.

The mixture spurred the cells to release inflammation - promoting molecules known to spur osteoclast production.

Coban and colleagues gave infected mice alfacalcidol, a derivative of vitamin D that treats osteoporosis by suppressing osteoclasts and stimulating osteoblasts.

Osteoblasts and osteoclasts send hormones to do their bidding.

Osteoclasts from mice that lacked Del - 1 or from cell lines lacking the protein could be differentiated faster and stronger.

High levels of bone destruction and reduced bone density caused by excessive osteoclasts are characteristic of osteoporosis, a common bone disease in which bones become fragile and susceptible to fracture.

Compared with a group of control animals, these mice produced twice as many osteoclasts and their bones also became thinner.

Through this visualization method, the researchers successfully captured images of osteoblasts and osteoclasts interacting in real - time in living bone tissue.

Researchers in Japan will study changes in the bone density of the fish in the Medaka Osteoclast investigation Dragon's round - trip carrying capacity also will help scientists build upon their previous work and explore new questions.

But if osteoclasts aren't working properly, «in the end, what you get is disorganized bone,» Malchodi says.

Working with fellow Washington University scientist Louis Muglia, Teitelbaum developed a line of transgenic mice with modified osteoclasts: The cells still functioned normally, but they lacked steroid receptors.

The ruffled surfaces of bone - dissolving osteoclasts (pink) indicate that they are stripping out stressed bone.

Mice with normal osteoclasts, however, produced inferior bones when given high doses of cortisone.

Then bone - making cells called osteoblasts and bone - absorbing cells called osteoclasts grow and sculpt new bone at the site of fracture.

Vitamin D performs the opposite trick — boosting osteoclast numbers — via a more circuitous route.

The fish used for this experiment have fluorescent osteoclast cells, which makes them easier to observe.

Using electron microscopes, investigators also observed abnormalities in osteoclast mitochondria.

Anne Roscher (Jessberger, TUD)-- «SWAP - 70 regulates osteoclast function by modulating the actin cytoskeleton» (2014)

Osteoblasts modulate osteoclast activity through secretion of the TNF family member RANKL (receptor activator of nuclear factor κB ligand).