Sentences with phrase «osteoclast activation»

IL - 6 is a multifunctional cytokine with pleiotropic functions that include inducing osteoclast activation, enhancing bone resorption, and increasing metastasis (33 — 35).

To directly examine whether ABL kinases regulate tumor - induced osteoclast activation, we used an in vitro osteoclastogenesis assay (Fig. 5A).

Depletion of ABL kinases impairs tumor - induced osteoclast activation in part by decreasing IL - 6 secretion.

IL - 6 can induce osteoclast activation indirectly by altering the expression of RANKL and OPG in osteoblasts (51).

These findings suggest that ABL kinases promote tumor - induced osteoclast activation in part by increasing OPG abundance in osteoblasts.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.

Addition of IL - 6 to reconstituted conditioned medium from ABL1 / ABL2 - depleted breast cancer cells partially restored osteoclast activation (Fig. 5, J and K).

Both MMP1 and IL - 6 have been linked to the regulation of osteoclast activation (32, 33), and depletion of TNC decreases breast cancer metastasis (49).

Genetic analysis also revealed significant increase in activity in two genes that may be involved in mitochondria function, suggesting that osteoclast activation might be linked to the reaction of mitochondria to microgravity.

This indicates that microgravity's effect on bone density likely involves changes in mechanical force that lowers overall physical activity and therefore causes osteoclast activation

Not exact matches

Now, the Laboratory of Malaria Immunology Team at the Immunology Frontier Research Center (IFReC), Osaka University, headed by Professor Cevayir COBAN, have used mouse malaria models to show that robust immune activation and invasion of parasite by - products into the bone marrow during and after malaria infection leads to an adverse balance in bone homeostasis - a process usually tightly controlled - by bone forming osteoblasts and bone resorbing osteoclasts.

TRANCE is necessary and sufficient for osteoblast - mediated activation of bone resorption in osteoclasts.

Several tumor - derived bone metastasis factors can increase RANKL production or decrease OPG secretion by osteoblasts, thereby promoting osteoclast differentiation and activation (12, 32).

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Bones One cup of boiled spinach provides over 1000 % of the RDA of vitamin K that can prevent excess activation of osteoclasts (the cells that break down bones), as well as promote the synthesis of osteocalcin, the protein that is essential for maintaining the strength and density of our bones.