Sentences with phrase «osteoclast cells»

To get slightly more scientific in terms of bone health, an acidic environment has been shown to encourage the activity of osteoclast cells.

Not exact matches

«The cancer cells can specifically activate the osteoclasts for bone degradation,» Wu said.

Ordinarily, bone is built up by cells called osteoblasts and reabsorbed during growth and healing by cells called osteoclasts.

In the bone, macrophages take the form of osteoclasts — the cells responsible for the resorptive processes associated with continuous bone remodeling.

The mixture spurred the cells to release inflammation - promoting molecules known to spur osteoclast production.

The parasites might trigger these problems, the scientists hypothesized, by upsetting the normal balance between cells known as osteoclasts, which dissolve bone, and cells called osteoblasts, which build it back up.

Cells known as osteoblasts make new bone; other cells, osteoclasts, destroy old Cells known as osteoblasts make new bone; other cells, osteoclasts, destroy old cells, osteoclasts, destroy old bone.

Not only can IL - 17 encourage inflammation, but it can also encourage the development of osteoclasts, cells that break down bone, in this case teeth.

Osteoclasts from mice that lacked Del - 1 or from cell lines lacking the protein could be differentiated faster and stronger.

This outcome is achieved because miR - 34a blocks the development of bone - destroying cells called osteoclasts, which make the bone less dense and prone to fracture.

Two types of cell maintain bone: osteoblasts, which create new bone tissue, and osteoclasts, which remove old tissue.

«Clarifying the interplay between bone cells in bone remodeling: Spatiotemporal intercellular interactions between mature osteoblasts and mature osteoclasts in bone homeostasis in vivo demonstrated.»

Therefore, it is important to understand the spatial - temporal relationship and interaction between osteoblasts and terminally differentiated osteocytes (bone cells) and osteoclasts in vivo.

Another proposal centers on cells called osteoclasts.

Osteoclasts are cells that break down the bone.

«MCP - 1 is a chemokine, which induces cells to move along a gradient recruiting white cells and osteoclasts in tissues,» says Dr. Partridge.

It influences the development of special cells, the so - called osteoclasts that are responsible for bone resorption.

Because high serum levels of MCP - 1 cause the white cells and osteoclasts to be stimulated, this process could have systemic effects as well as effects on bone.

So Steven Teitelbaum, a bone cell biologist at Washington University School of Medicine in St. Louis, Missouri, decided to focus instead on the bone dismantlers, the osteoclasts.

As might be expected, it reduces the number of bone - dissolving cells, or osteoclasts, in mice with a condition resembling osteoporosis.

By adding vitamin D to a petri dish full of osteoclast precursors, they discovered that the hormone blocked a signal called RANK ligand that tells these cells to become osteoclasts.

Proper bone development is maintained through a fine balance of bone - forming (osteoblast) and bone - resorbing (osteoclast) cells.

Then bone - making cells called osteoblasts and bone - absorbing cells called osteoclasts grow and sculpt new bone at the site of fracture.

The WNT7B protein had no effect on the total activity of bone - degrading osteoclasts but substantially increased the number of bone - building osteoblast cells.

Initially, fluoxetine protects bone by inhibiting the cells in the skeleton (osteoclasts) that constantly break down and resorb bone.

Our bones are in a constant state of flux as the number of bone - making (osteoblast) cells fluctuates, while the number of bone - degrading (osteoclast) cells also adjusts.

Previous studies suggest that microgravity activates osteoclasts, cells that control the breakdown of bone tissue, and the Medaka fish investigation examined the relationship between this increased osteoclast activity and reduced bone mineral density.

Tobias Heckel (Hoflack, TUD)-- «Revealing Src tyrosine kinase - dependent signaling pathways in osteoclasts: Implications on actin organization and cell polarity» (2008)

4 - 1BBL was largely thought to be on APC that have been activated for several days, such as dendritic cells, B cells, and macrophages although again it is clear that 4 - 1BBL is now more ubiquitous as it has been visualized to be induced on diverse cell types such as mast cells, osteoclasts, smooth muscle, and stem cells.

We added the optimal dose of IL - 6 required to promote maturation of osteoclasts (Fig. 5I) to conditioned medium derived from ABL1 / ABL2 knockdown breast cancer cells.

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

To evaluate whether ABL kinases might regulate the secretion of osteoblast - derived RANKL or OPG leading to osteoclast differentiation, we analyzed RANKL and OPG mRNA abundance in the murine osteoblast cell line 7F2 in response to conditioned medium from control and ABL1 / ABL2 knockdown breast cancer cells.

Addition of IL - 6 to reconstituted conditioned medium from ABL1 / ABL2 - depleted breast cancer cells partially restored osteoclast activation (Fig. 5, J and K).

Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.

In breast cancer cells, the ABL kinases activated the transcriptional coactivator TAZ and the transcription factor STAT5, which triggered the transcription of genes encoding factors that activate osteoclasts (cells that break down bone) and those that enhance the survival of breast cancer cells in the bone microenvironment.

Bisphosphonates, for example, disrupt the remodeling of normal bone by shutting down the osteoclasts - the cells which break down old bone to produce new bone.

«First, cells known as osteoclasts remove old, weakened bone,» explains Andrea Singer, MD, clinical director of the NOF.

Research has shown that strontium may play a role in the formation of osteoblasts, new bone forming cells, while at the same time slowing the breakdown of old bone by inhibiting osteoclasts.

Not only does lactoferrin increase osteoblast activity, it also reduces the formation of osteoclasts, and these bone cells help to increase bone turn - over or bone loss.

It stimulates the production of calcitonin, the hormone responsible for inhibiting cells (osteoclasts) that breaks bone down and activates alkaline phosphatase, an enzyme that forms new calcium crystals in bones.

When it becomes more acidic, there's a higher rate of activity of cells called osteoclasts, which break down bone.

Osteoclasts are parts of the cell that nibble away at bone so new bone can be laid, without them, we can't grow strong bones.

Estrogen suppresses the production of osteoclasts, the cells that break down the bone and slow the activity of existing osteoclasts.

Bones One cup of boiled spinach provides over 1000 % of the RDA of vitamin K that can prevent excess activation of osteoclasts (the cells that break down bones), as well as promote the synthesis of osteocalcin, the protein that is essential for maintaining the strength and density of our bones.

Here's a quote: «Lactoferrin: Lactoferrin found in foods such as yogurt and kefir will stimulate new bone growth while preventing further breakdown of existing bone tissue, lactoferrin enhances both the growth and the activity of osteoblasts (the cells that build bone), and reduces the rate of bone cell death by 50 to 70 percent and decreases the development of osteoclasts, the cells responsible for breaking down bone.»