Sentences with phrase «osteoclast function»

Not exact matches

To accomplish their functions, bones undergo continuous destruction (resorption) carried out by osteoclasts, and formation by osteoblasts.

Genetic analysis also revealed significant increase in activity in two genes that may be involved in mitochondria function, suggesting that osteoclast activation might be linked to the reaction of mitochondria to microgravity.

These findings suggest that ABL kinases regulate osteoclast maturation indirectly, possibly by modulating osteoblast function.

IL - 6 is a multifunctional cytokine with pleiotropic functions that include inducing osteoclast activation, enhancing bone resorption, and increasing metastasis (33 — 35).

To investigate the underlying mechanisms, we undertook (1) bioinformatic, functional genomic annotation and human osteoblast expression studies; (2) gene - function prediction; (3) skeletal phenotyping of 120 knockout mice with deletions of genes adjacent to lead independent SNPs; and (4) analysis of gene expression in mouse osteoblasts, osteocytes and osteoclasts.

And they found that blood serum obtained following the consumption of an almond meal inhibits human osteoclast formation, function, and gene expression, providing direct evidence to support the association between regular almond consumption and a reduced risk of developing osteoporosis.