Sentences with phrase «osteoclasts required»

Through its various targets, MMP1 promotes not only tumor invasion but also breast cancer colonization to bone by mechanisms that include the release of membrane - bound EGF - like growth factors from tumor cells, leading to activation of EGF receptor signaling and suppression of OPG expression in osteoblasts, which in turn promotes the differentiation and activation of osteoclasts required for bone destruction and enhanced tumor growth in the bone microenvironment (32).

Not exact matches

We added the optimal dose of IL - 6 required to promote maturation of osteoclasts (Fig. 5I) to conditioned medium derived from ABL1 / ABL2 knockdown breast cancer cells.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.