Sentences with phrase «osteolysis in»

We found that allosteric inhibition of the ABL kinases effectively impaired breast cancer bone metastasis and blocked tumor - induced osteolysis in mouse models.

Moreover, we found that treatment with a selective allosteric inhibitor of the ABL kinases or simultaneous depletion of both ABL kinases in breast cancer cells impaired breast cancer bone metastases and decreased osteoclast activation in vitro and osteolysis in vivo.

These findings reveal a function for ABL kinases in the regulation of breast cancer bone metastasis and tumor - induced osteolysis in vivo.

The artwork appeared on the front cover of Applied Surface Science summarizes the benefits of a new bioceramic coating versus the commercially available Calcium Phosphate which develops microcracks during processing and may later cause osteolysis in load - bearing orthopedic implants.

Not exact matches

Bone loss (osteolysis) was observed in many cases.

Intravital microscopy of prostate cancer lesions in bone: Kinetics of osteolysis and therapy response.

Intravital microscopy of prostate cancer lesions in bone: kinetics of osteolysis and therapy response.

These factors include chemokine (C - X-C motif) ligand 12 (CXCL12), a chemokine produced by bone marrow mesenchymal cells that functions as a chemoattractant and survival factor for cells bearing the chemokine (C - X-C motif) receptor 4 (CXCR4), and insulin - like growth factor 1 (IGF - 1), a factor that is stored in the bone matrix and released during osteolysis (28).

Joint fluid, tissue, and debris from implant wear can lodge in these spaces, causing eventual bone damage known as osteolysis.