Sentences with phrase «osteolytic metastasis»

These results demonstrate that ABL kinase activity is required for osteolytic metastasis in breast cancer and suggest that pharmacological inhibition of the ABL kinases may be an effective treatment for bone metastasis.

Our data raise the possibility that inhibition of ABL kinases can increase apoptosis of breast cancer cells and block osteoclast activation, which is required for osteolytic metastasis.

Not exact matches

ADAMTS1 and MMP1 proteolytically engage EGF - like ligands in an osteolytic signaling cascade for bone metastasis

Decreased metastasis by ABL - deficient breast cancer cells was accompanied by a significant reduction in the extent of hindlimb osteolytic lesions, as determined by x-ray and micro — computed tomography (μCT) imaging (Fig. 2, I and J).