I'm not going to debate the safety and health issues with memory foam toppers and mattresses here, as it seems to be a contentious topic for those who notice no VOC off - gassing or
other adverse effects from their synthetic foam mattress.
Not exact matches
Important factors that could cause actual results to differ materially
from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the
effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the
effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the
effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or
other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our
other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and
other customers, and the risk of nonpayment by such customers; 13) any
adverse impact on Boeing's and Airbus» production of aircraft resulting
from cancellations, deferrals, or reduced orders by their customers or
from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any
adverse impact on the demand for air travel or our operations
from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover
from cyber-based or
other security attacks, information technology failures, or
other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition
from commercial aerospace original equipment manufacturers and
other aerostructures suppliers; 19) the
effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the
effect of changes in tax law, such as the
effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the
effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and
other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and
other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses,
adverse changes to business relationships and
other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among
other things.
These risks and uncertainties include, among
others: the unfavorable outcome of litigation, including so - called «Paragraph IV» litigation and
other patent litigation, related to any of our products or products using our proprietary technologies, which may lead to competition
from generic drug manufacturers; data
from clinical trials may be interpreted by the FDA in different ways than we interpret it; the FDA may not agree with our regulatory approval strategies or components of our filings for our products, including our clinical trial designs, conduct and methodologies and, for ALKS 5461, evidence of efficacy and adequacy of bridging to buprenorphine; clinical development activities may not be completed on time or at all; the results of our clinical development activities may not be positive, or predictive of real - world results or of results in subsequent clinical trials; regulatory submissions may not occur or be submitted in a timely manner; the company and its licensees may not be able to continue to successfully commercialize their products; there may be a reduction in payment rate or reimbursement for the company's products or an increase in the company's financial obligations to governmental payers; the FDA or regulatory authorities outside the U.S. may make
adverse decisions regarding the company's products; the company's products may prove difficult to manufacture, be precluded
from commercialization by the proprietary rights of third parties, or have unintended side
effects,
adverse reactions or incidents of misuse; and those risks and uncertainties described under the heading «Risk Factors» in the company's most recent Annual Report on Form 10 - K and in subsequent filings made by the company with the U.S. Securities and Exchange Commission («SEC»), which are available on the SEC's website at www.sec.gov.
These risks and uncertainties include competition and
other economic conditions including fragmentation of the media landscape and competition
from other media alternatives; changes in advertising demand, circulation levels and audience shares; the Company's ability to develop and grow its online businesses; the Company's reliance on revenue
from printing and distributing third - party publications; changes in newsprint prices; macroeconomic trends and conditions; the Company's ability to adapt to technological changes; the Company's ability to realize benefits or synergies
from acquisitions or divestitures or to operate its businesses effectively following acquisitions or divestitures; the Company's success in implementing expense mitigation efforts; the Company's reliance on third - party vendors for various services;
adverse results
from litigation, governmental investigations or tax - related proceedings or audits; the Company's ability to attract and retain employees; the Company's ability to satisfy pension and
other postretirement employee benefit obligations; changes in accounting standards; the
effect of labor strikes, lockouts and labor negotiations; regulatory and judicial rulings; the Company's indebtedness and ability to comply with debt covenants applicable to its debt facilities; the Company's ability to satisfy future capital and liquidity requirements; the Company's ability to access the credit and capital markets at the times and in the amounts needed and on acceptable terms; and
other events beyond the Company's control that may result in unexpected
adverse operating results.
For example, the expected timing and likelihood of completion of the proposed merger, including the timing, receipt and terms and conditions of any required governmental and regulatory approvals of the proposed merger that could reduce anticipated benefits or cause the parties to abandon the transaction, the ability to successfully integrate the businesses, the occurrence of any event, change or
other circumstances that could give rise to the termination of the merger agreement, the possibility that Kraft shareholders may not approve the merger agreement, the risk that the parties may not be able to satisfy the conditions to the proposed transaction in a timely manner or at all, risks related to disruption of management time
from ongoing business operations due to the proposed transaction, the risk that any announcements relating to the proposed transaction could have
adverse effects on the market price of Kraft's common stock, and the risk that the proposed transaction and its announcement could have an
adverse effect on the ability of Kraft and Heinz to retain customers and retain and hire key personnel and maintain relationships with their suppliers and customers and on their operating results and businesses generally, problems may arise in successfully integrating the businesses of the companies, which may result in the combined company not operating as effectively and efficiently as expected, the combined company may be unable to achieve cost - cutting synergies or it may take longer than expected to achieve those synergies, and
other factors.
As a result, political instability, labor strikes, natural disasters or
other events resulting in the disruption of trade or transportation
from other countries or the imposition of additional regulations relating to duties upon imports could cause significant delays or interruptions in the supply of our merchandise or increase our costs, either of which could have an
adverse effect on our business.
«Negative publicity or public opinion resulting
from these matters may increase the risk of reputational harm to our business, which can impact our ability to keep and attract customers, our ability to attract and retain qualified team members, result in the loss of revenue, or have
other material
adverse effects on our results of operations and financial condition.»
The
effects on the US share market, on the
other hand, have been mixed: there have been some benefits
from lower interest rates but the profit results of US companies are increasingly showing signs of
adverse impacts
from Asian competition.
IF THE COMPANY BELIEVES, IN ITS SOLE DISCRETION, THAT ANY INDIVIDUALS OR ENTITIES OWNING CTK CREATES MATERIAL REGULATORY OR
OTHER LEGAL RISKS OR
ADVERSE EFFECTS FOR THE COMPANY AND / OR CTK, THE COMPANY RESERVES THE RIGHT TO: (A) BUY ALL CTK
FROM SUCH CTK OWNERS AT THE THEN - EXISTING MARKET PRICE AND / OR (B) SELL ALL CRYPTOCURRENCY ASSETS OF THE COMPANY.
but fortunately there are psychologists, mental health practitioners and
others who do and I have benefitted greatly
from their work, personal testimonies and the various articles / publications which they have produced --(for example, The Journal of Transpersonal Psychology; The Religious & Spiritual Problems category in the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM - IV) published by the American Psychiatric Association; The US National Library of Medicine National Institutes of Health PubMed.gov database of healthcare and scientific literature)-- about the
adverse psychological
effects which can arise when persons engage in intense / deep spiritual practices such as intense / deep prayer, fasting and meditation which alter their state of consciousness.
The problems like these that arise
from BC pills, or shots, are far smaller then the
adverse side
effects of almot every
other med on the market.
While the move has resulted in an increase in production
from the Carolina offense, it has had a nearly equally
adverse effect on the
other end.
When
adverse effects were found, they were «inconsistent
from one study to the
other, always relatively minor, and appear to have no impact on infant health or mortality.»
After they're breathing on their own (or even if they did
from the start), these babies may have continuing breathing problems — because of delayed lung development or
other adverse effects of nicotine.
After they are breathing on their own, or even if they did
from the start, these babies may have continuing breathing problems, because of delayed lung development or
other adverse effects of nicotine.
Among
other things, residents are worried about the health impacts of adding Cortland County's trash to the incinerator, suggesting dioxins coming
from the plant have already had
adverse health
effects on residents.
Results showed that d - ribose supplementation didn't promote the formation of glycated plasma proteins or any
other adverse effects, and actually protected the horses
from cramping while enhancing muscle recovery.
We know
from other research that the period between early adolescence and young adulthood is a sensitive period for weight gain that has
adverse effects on cardiovascular health later in life.»
The BUSM researchers believe the data
from this study and those reported by
others in animal models as well in clinical studies strongly suggest that Avodart may have serious
adverse side
effects that were not obvious several years ago.
Studies of
other cities have already projected
adverse health
effects from rising temperatures, but this is one of the most comprehensive so far.
With the microRNA signatures of mitochondrial function and dysfunction in RPE cells in hand, combined with a detailed mechanistic understanding of how these microRNAs are transferred
from cell to cell, we can use small interfering RNAs to target specific microRNAs and block their
adverse effects on mitochondria function and their transfer to
other RPE cells.
SciLifeLab gave her a call to learn more about how her team contributes to the understanding of why some people get severe
adverse effects from medical drug treatments while
others do not.
«The evidence for
adverse reproductive outcomes (infertility, cancers, malformations)
from exposure to endocrine - disrupting chemicals is strong, and there is mounting evidence for
effects on
other endocrine systems, including thyroid, neuroendocrine, obesity and metabolism, and insulin and glucose homeostasis.»
Anabolic steroid abuse has been associated with a wide range of
adverse side
effects ranging
from some that are physically unattractive, such as acne and breast development in men, to
others that are life threatening, such as heart attacks and liver cancer.
In variations, the method 100 can be used to promote targeted therapies to subjects suffering
from an autoimmune condition, disorder, or
adverse state, wherein the autoimmune condition produces systemic
effects in terms of one or more of: immune response, respiratory function, musculoskeletal function, gastrointestinal function, circulatory system function, endocrine system function, and any
other suitable physiological or behavioral function.
Any potential
adverse effect of gluconeogenesis would be determined
from the initial substrate; whether one is using amino acids to manufacture glucose or
other precursors that are extremely benign such as
from ketones, the glycerol backbone of fats, or
from lactate and pyruvate recycling.
If the body can make all the glucose it needs
from other biochemicals, called gluconeogenesis, are there potential
adverse effects from this?
Other more serious
adverse effects that can occur
from a few months to a few years after starting oral contraceptives include high blood pressure, gallbladder disease, liver tumors, depression, and metabolic disorders, such as diabetes.
Other containers bought earlier
from both companies showed no
adverse side
effects but I'm now looking for another calcium - magnesium source to add to my oatmeal in the morning.
Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among
others, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service,
effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and
other merchandise and
other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns
from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and
other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated
adverse litigation results or
effects, product and component shortages, the potential
adverse impact on the Company's businesses resulting
from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses, the risk that the transactions with Microsoft and Pearson do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion contemplated by the relationship with Microsoft, including that it is not successful or is delayed, the risk that NOOK Media is not able to perform its obligations under the Microsoft and Pearson commercial agreements and the consequences thereof, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and
other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, and in Barnes & Noble's
other filings made hereafter
from time to time with the SEC.
Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among
others, the
effect of the proposed separation of NOOK Media, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, possible disruptions in Barnes & Noble's computer systems, telephone systems or supply chain, possible risks associated with data privacy, information security and intellectual property, possible work stoppages or increases in labor costs, possible increases in shipping rates or interruptions in shipping service,
effects of competition, possible risks that inventory in channels of distribution may be larger than able to be sold, possible risks associated with changes in the strategic direction of the device business, including possible reduction in sales of content, accessories and
other merchandise and
other adverse financial impacts, possible risk that component parts will be rendered obsolete or otherwise not be able to be effectively utilized in devices to be sold, possible risk that financial and operational forecasts and projections are not achieved, possible risk that returns
from consumers or channels of distribution may be greater than estimated, the risk that digital sales growth is less than expectations and the risk that it does not exceed the rate of investment spend, higher - than - anticipated store closing or relocation costs, higher interest rates, the performance of Barnes & Noble's online, digital and
other initiatives, the success of Barnes & Noble's strategic investments, unanticipated increases in merchandise, component or occupancy costs, unanticipated
adverse litigation results or
effects, product and component shortages, risks associated with the commercial agreement with Samsung, the potential
adverse impact on the Company's businesses resulting
from the Company's prior reviews of strategic alternatives and the potential separation of the Company's businesses (including with respect to the timing of the completion thereof), the risk that the transactions with Pearson and Samsung do not achieve the expected benefits for the parties or impose costs on the Company in excess of what the Company anticipates, including the risk that NOOK Media's applications are not commercially successful or that the expected distribution of those applications is not achieved, risks associated with the international expansion previously undertaken, including any risks associated with a reduction of international operations following termination of the Microsoft commercial agreement, the risk that NOOK Media is not able to perform its obligations under the Pearson and Samsung commercial agreements and the consequences thereof, the risks associated with the termination of Microsoft commercial agreement, including potential customer losses, risks associated with the restatement contained in, the delayed filing of, and the material weakness in internal controls described in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 27, 2013, risks associated with the SEC investigation disclosed in the quarterly report on Form 10 - Q for the fiscal quarter ended October 26, 2013, risks associated with the ongoing efforts to rationalize the NOOK business and the expected costs and benefits of such efforts and associated risks and
other factors which may be outside of Barnes & Noble's control, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended May 3, 2014, and in Barnes & Noble's
other filings made hereafter
from time to time with the SEC.
Such statements reflect the current views of Barnes & Noble with respect to future events, the outcome of which is subject to certain risks, including, among
others, the general economic environment and consumer spending patterns, decreased consumer demand for Barnes & Noble's products, low growth or declining sales and net income due to various factors, including store closings, higher - than - anticipated or increasing costs, including with respect to store closings, relocation, occupancy (including in connection with lease renewals) and labor costs, the
effects of competition, the risk of insufficient access to financing to implement future business initiatives, risks associated with data privacy and information security, risks associated with Barnes & Noble's supply chain, including possible delays and disruptions and increases in shipping rates, various risks associated with the digital business, including the possible loss of customers, declines in digital content sales, risks and costs associated with ongoing efforts to rationalize the digital business and the digital business not being able to perform its obligations under the Samsung commercial agreement and the consequences thereof, the risk that financial and operational forecasts and projections are not achieved, the performance of Barnes & Noble's initiatives including but not limited to its new store concept and e-commerce initiatives, unanticipated
adverse litigation results or
effects, potential infringement of Barnes & Noble's intellectual property by third parties or by Barnes & Noble of the intellectual property of third parties, and
other factors, including those factors discussed in detail in Item 1A, «Risk Factors,» in Barnes & Noble's Annual Report on Form 10 - K for the fiscal year ended April 30, 2016, and in Barnes & Noble's
other filings made hereafter
from time to time with the SEC.
Among
other things, the Board may withdraw the Reverse Split if any of the following occur: (1) a change in the nature of our shareholdings that (a) would prevent us
from reducing the number of record holders below 300 as a result of the Reverse Split, or (b) would reduce the number of record holders below 300 persons without
effecting the Reverse Split; (2) a change in the number of shares to be exchanged for cash in the Reverse Split that would substantially increase the cost and expense of the Reverse Split (as compared to what is currently anticipated); or (3) any
adverse change in our financial condition that would render the Reverse Split inadvisable.
Second, take note of
other medications that you give your dog as ingredients
from different medicines may cause
adverse effects.
We have never had anyone complain of
adverse effects from the chlorine
other then a bit of dry skin.
At least two municipal governments reassured investors that they were «unable to predict whether sea - level rise or
other impacts of climate change or flooding
from a major storm will occur, when they may occur, and if any such events occur, whether they will have a material
adverse effect...»» (emphasis added)
As discussed earlier, Hurricane Katrina demonstrated that communities of color, poor communities, and certain
other vulnerable populations (like new immigrant communities) are at a higher risk to the
adverse effects of extreme weather events.263, 264,239 These vulnerable populations could benefit
from urban planning policies that ensure that new buildings, including homes, are constructed to resist extreme weather events.303
A 2017 disclosure by San Francisco reads: «The city is unable to predict whether sea level rise or
other impacts of climate change or flooding
from a major storm will occur, when they may occur, and if any such events occur, whether they will have a material
adverse effect on the business operations or financial condition of the city and the local economy.»
From hazardous
effects causing potential loss of life, injury, or
other negative health impacts, to the potential exposure of social, economic, and infrastructure assets to
adverse impacts, global warming places vulnerable human lives and systems in dangerous jeopardy.
Even with warming of 2 °C, we can expect to see
adverse effects on water availability in critical river basins, a more than doubling of forest fires in Amazonia by 2050, impacted coral reef recovery
from bleaching events, among
other effects.
In Bressol (2010), the Court not only held that the choice between open and restricted university access was one for the Member States to make, but it also found a quota on non-resident students for certain para-medical studies justifiable in the light of the unsolved problems arising
from the fact that the Member States organize their higher education systems in ways that create
adverse effects for
other Member States.
Where a person will not give way over an issue at work, but in
other respects suffers little
adverse effects on their day - today activities they might be suffering
from stress, but the EAT held that a tribunal is «not bound to find that there is a mental impairment in such a case.»
Although some of them are easy to identify,
others are less obvious, such as those that result
from unconscious prejudices and stereotypes or
from standards that are neutral on their face but have
adverse effects on certain persons.
Does Seroxat have a capacity to cause
adverse effects consequent upon or following discontinuance (withdrawl) such as prevent or make more difficult the ability of users to discontinue, withdrawal
from or remain free
from taking Seroxat to a greater extent than all
other Selective Serotonin Re-uptake Inhibitors (SSRIs).
As to the substantive issue, contrary to the view of the Joint Committee on Human Rights (JCHR), the court held that preventing a person
from smoking did not generally involve such an
adverse effect upon their physical or moral integrity, or upon any of the
other concepts cited above, as would amount to an interference with their right to respect for private or home life (para 101).
On the
other hand the «brain grow hormone» DHEA, helps your brain to become stronger
from stressful experiences, and it eliminates a number of
adverse effects of Cortisol.
• Demonstrated expertise in monitoring patients» post-surgical vital signs to ensure their stability and wellbeing • Deep insight into operating equipment such as cardiac monitors and pulse oximeters and quickly diagnosing problems and responding promptly • Proficient in handling pain management by ensuring a thorough comprehension of pain medications and safe ways of administering them • Adept at handling patient - controlled analgesia pumps and IVs and epidural anesthesia to ensure patient comfort • Qualified to monitor patients for
adverse reactions to anesthesia and pain management medications by employing deep insight into anesthesia and how it affects the human body • Hands - on experience in handling critical care procedures post-surgery to ensure increased patient safety and comfort • Proven ability to manage post-operative pain by administering pain medication and assisting patients recover
from the
effects of anesthesia • Competent at handling patients with post-operative nausea and vomiting by ensuring that steps are taken to ward off respiratory pneumonia and
other life threatening conditions • Unmatched ability to assess patients» conditions in post-surgical environments and implement post-surgical treatment plans to ensure increased chances of patient recovery and comfort
This differs
from previous studies that use this cohort, where exposure in pregnancy had a significantly greater
effect on
other types of
adverse child outcomes.23 28 These findings may indicate that the relationship between school attendance and maternal alcohol use disorders is not primarily driven by the neurobehavioural
effects of alcohol during pregnancy, but rather a complex family and social environment in which school attendance is not a priority or not well monitored.
First, are the
effects of different
adverse childhood experiences distinct
from each
other?
• to describe the lives of children in Ireland, in order to establish what is typical and normal as well as what is atypical and problematic; • to chart the development of children over time, in order to examine the progress and wellbeing of children at critical periods
from birth to adulthood; • to identify the key factors that, independently of
others, most help or hinder children's development; • to establish the
effects of early childhood experiences on later life; • to map dimensions of variation in children's lives; • to identify the persistent
adverse effects that lead to social disadvantage and exclusion, educational difficulties, ill health and deprivation; • to obtain children's views and opinions on their lives; • to provide a bank of data on the whole child; and to provide evidence for the creation of effective and responsive policies and services for children and families; • to provide evidence for the creation of effective and responsive policies and services for children and families.