These patents cover aspects of Celgene's Abraxane drug product, which is approved to treat metastatic breast cancer and
other aggressive cancers.
Not exact matches
The
other, a former White House aide to President Obama, tested positive for the BRCA2 gene mutation that has led to breast
cancer in her family for generations — and is taking
aggressive steps to avoid the same fate.
Dr. Marcus E. Martinez, who runs a family medical practice in Hoosick Falls, told the Times Union last year that he and his father, who opened the practice in 1956, have noted rare and
aggressive forms of
cancer in patients, as well as thyroid disease and
other health problems.
Scientists have uncovered how tumor cells in
aggressive uterine
cancer can switch disguises and spread so quickly to
other parts of the body.
«This research represents a big step forward in understanding why some tumors are more
aggressive than
others and being able to predict rationally which neoantigens will be the most effective at stimulating an immune response,» said Dr. Balachandran, a member of the David M. Rubenstein Center for Pancreatic
Cancer Research at MSK, and corresponding author of the companion study in Nature.
The new name cites key features to guide pathologists in diagnosis, but omits the word «
cancer,» indicating that it need not be treated with radioiodine or
other aggressive approaches.
In most patients, the disease will stay inactive for years, while in
others, it will suddenly erupt and turn into an
aggressive and life threatening
cancer.
While some prostate
cancers are
aggressive and lethal,
others are clinically insignificant and will never lead to any harm or death if left undetected.
Triple - negative tumors are
aggressive and more likely to metastasize than
other breast
cancers, and there is no effective treatment.
But those patients often have many
other health problems that lead to death before even
aggressive prostate
cancer.
«Our findings suggest that this new drug combination would also help patients with this type of
aggressive breast
cancer as well as
other cancers, such as lung, prostate and ovarian
cancers,» Dr. Rassool says.
Even more troubling, her study found a link between high blood levels of lycopene's chemical cousin, beta - carotene, and an increased risk of
aggressive prostate
cancer — not enough to justify avoiding carrots and
other food sources of beta - carotene but an ominous sign that not all food - derived compounds are necessarily benign when taken at higher doses.
In a new study published in The Journal of Urology ®, researchers determined that men who followed a Mediterranean diet, rich in fish, boiled potatoes, whole fruits, vegetables, legumes, and olive oil, and low consumption of juices had lower risk of
aggressive prostate
cancer (PC) than those who followed
other dietary patterns like Prudent or Western diets.
The prognosis of myeloma patients with EMD behaves like
other metastatic
cancers and is extremely poor because its clinical course is very
aggressive, Tse said.
Patients with high levels of miR - 194 in their blood could receive more
aggressive treatment to reduce the chance of the
cancer spreading to
other parts of the body.»
The study evaluated 56 patients with ovarian clear cell adenocarcinoma (CCA), an
aggressive form of ovarian
cancer that is more likely to be resistant to chemotherapy and to have a poorer prognosis than
other forms of this disease.
The authors stressed that the long - term reduction in
aggressive disease was observed only in men after more than a year of testosterone use, and the risk of prostate
cancer did not differ between gels and
other types of preparations.
Chemotherapy and
other cancer treatments are supposed to get rid of the disease, but a new study finds they can elicit
aggressive tumor growth instead, STAT reports today.
But
other types — colon and bladder
cancer and certain leukemias, for example — are usually more
aggressive and harder to treat.
Hydrochlorothiazide increased the risk of basal cell carcinoma, which is the least serious type of skin
cancer, as well as of squamous cell carcinoma, which is more
aggressive and in some cases manages to spread to
other parts of the body.
The team chose to compare breast tissue from healthy individuals with tumor samples taken from breast
cancer patients — including both primary tumors that had not spread from the breast to
other body sites, and highly
aggressive, metastatic tumors.
In the
other 77, the
cancer either wouldn't have caused harm if left untreated or is so
aggressive that treatment doesn't help.
Researchers at Washington University School of Medicine in St. Louis have discovered why breast
cancer patients with dense breasts are more likely than
others to develop
aggressive tumors that spread.
But while it may not be as common as
other skin
cancers, MCC is highly
aggressive and often deadly — and it's also becoming more common, according to new research published in the Journal of the American Academy of Dermatology and presented at the American Academy of Dermatology 2018 Annual Meeting in San Diego.
The researchers are now further investigating the possibility of using this approach on
other cancers, including prostate
cancer, where it could be used to distinguish more
aggressive tumors from those that grow much more slowly, Bhatia says.
Previous in vitro studies conducted by researchers in
other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most
aggressive type of skin
cancer, as well as breast
cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.
The panel also called for «
aggressive research» on using RU486 and
other drugs in the antiprogrestin class as contraceptives and as treat - ment for endometriosis, uter - ine fibroids, advanced breast
cancer and meningioma brain tumours.
Since most men with prostate
cancer have indolent (non-
aggressive) disease for which conservative therapy or surveillance would be appropriate treatment, the clinical challenge is not only how to identify those with prostate
cancer, but also how to distinguish those who would benefit from surgical or
other aggressive treatment from those who would not.
Compared to
other types of breast
cancer, triple negative breast
cancers are often more
aggressive and have fewer treatment options.
In
other words, those likely cured through
aggressive treatment were followed more closely than patients whose
cancers were left untreated.»
Of those that had the high - risk signature,
cancer spread to the lungs in 55 %, in spite of chemotherapy treatment, whereas only 10 % of the
others showed
cancer migration to the lungs — and even then, the lungs were not the principal or most
aggressive site, the team reports 28 July in Nature.
Further, the relationship between Myc and TXNIP is not observed in
other types of breast
cancer, suggesting that it is a feature of only
aggressive triple negative breast
cancers and not
other less
aggressive breast
cancer types.
In unrelated studies,
other researchers have linked XMRV — again controversially — to an
aggressive form of prostate
cancer.
In the era of personalized
cancer therapy, patients with TNBC remain at considerably higher risk of relapse and death than patients with
other breast
cancer subtypes, due to the
aggressive nature of TNBC and the lack of newer targeted therapies for the disease.
Among patients with advanced
cancer and
other serious illnesses,
aggressive treatments are often inconsistent with patients» wishes and are associated with worse quality of life compared to
other treatments.
«Triple - negative breast
cancers tend to be more
aggressive compared to
other types of breast
cancers, and being able to predict response to therapy could greatly impact treatment decisions and patient outcomes,» says study author Shaveta Vinayak, MD, oncologist at UH Case Medical Center and Assistant Professor at Case Western Reserve University School of Medicine.
Immunotherapy using checkpoint inhibitors has changed the way we treat several
aggressive cancers such as melanoma, non-small cell lung and head & neck
cancers, among
others, with durable responses achieved in the metastatic setting.
Dr. Corrie Painter first turned to Facebook to find
others who shared her rare,
aggressive cancer.
Differently from all
other proteins in this class, survivin is selectively over-expressed in virtually every human
cancer where it signals more
aggressive disease and unfavorable outcome.
An
aggressive form of
cancer, desmoid fibromatosis often spreads to
other parts of the body.
One of the SNPs is located on the X chromosome and the
other SNP is located on chromosome 2p15 and is associated with a more
aggressive form of prostate
cancer.
Professor Ros Eeles from the Institute of
Cancer Research and The Royal Marsden, who co-leads the prostate cancer ICGC study with Professor Colin Cooper from the ICR and Professors David Neal and Douglas Easton from The University of Cambridge, said: «One of the major challenges in treating prostate cancer is determining who needs aggressive treatment — some are slow growing and will never need treatment whilst others will develop qu
Cancer Research and The Royal Marsden, who co-leads the prostate
cancer ICGC study with Professor Colin Cooper from the ICR and Professors David Neal and Douglas Easton from The University of Cambridge, said: «One of the major challenges in treating prostate cancer is determining who needs aggressive treatment — some are slow growing and will never need treatment whilst others will develop qu
cancer ICGC study with Professor Colin Cooper from the ICR and Professors David Neal and Douglas Easton from The University of Cambridge, said: «One of the major challenges in treating prostate
cancer is determining who needs aggressive treatment — some are slow growing and will never need treatment whilst others will develop qu
cancer is determining who needs
aggressive treatment — some are slow growing and will never need treatment whilst
others will develop quickly.
A New Twist in Breast
Cancer Working with mice, scientists have shown that a protein made by a gene called TWIST may be the proverbial red flag that can accurately distinguish cells that drive aggressive, metastatic breast cancer from other breast cancer
Cancer Working with mice, scientists have shown that a protein made by a gene called TWIST may be the proverbial red flag that can accurately distinguish cells that drive
aggressive, metastatic breast
cancer from other breast cancer
cancer from
other breast
cancer cancer cells.
Overall, the top 15
cancers account for 81 percent of deaths, but some
cancers are more
aggressive and lethal than
others.
Roswell Park
Cancer Institute researchers have identified a gene that influences metastasis in prostate cancer, and may help clinicians to identify aggressive prostate tumors before they progress and spread to other o
Cancer Institute researchers have identified a gene that influences metastasis in prostate
cancer, and may help clinicians to identify aggressive prostate tumors before they progress and spread to other o
cancer, and may help clinicians to identify
aggressive prostate tumors before they progress and spread to
other organs.
Indeed trans - fats are known to lead to
aggressive fat gain, heart disease diabetes and a multitude of inflammatory disorders,
cancer and various
other diseases.
It is also important to note that inflammatory breast
cancer is much more
aggressive than the
other types of invasive breast
cancers we have discussed, including both invasive ductal carcinoma and invasive lobular carcinoma.
Unlike
other breast
cancers that involve hormone receptors and HER2 receptors, this
aggressive form of
cancer relies on genetic therapeutics aimed at repairing celluar DNA and keeping epidermal growth factors from sending cellular signals.
Myself I'm not a doctor but my sister had breast
cancer at 24 the first time received a radical mastectomy, chemo and radiation she got it the second time at 35 and had a mastectomy on the
other breast (not radical) chemo and radiation as well both time they were very
aggressive cancers.
It is an
aggressive cancer that can rapidly grow and invade structures around the mouth, and can spread to
other areas of the body.