Over $ 30 million was added for cancer and Gulf War Illness research, and
other amendments increased funding for military munitions research, medical technology, and the Navy's electromagnetic railgun project.
Not exact matches
Other amendments include funding for
increased anti-missile defense for the homeland as well as space - based missile interceptors.
These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and
other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may
increase the amount of discount required on Gilead's products; an
increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential
amendments to the Affordable Care Act or
other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over
other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or
other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and
other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).
The
amendment, among
other things,
increased the aggregate principal amount of revolving commitments to $ 350 million, extended the maturity date of the revolving credit facility to 2023 and made certain
other changes to the covenants and
other provisions.
Examples of these risks, uncertainties and
other factors include, but are not limited to the impact of: adverse general economic and related factors, such as fluctuating or
increasing levels of unemployment, underemployment and the volatility of fuel prices, declines in the securities and real estate markets, and perceptions of these conditions that decrease the level of disposable income of consumers or consumer confidence; adverse events impacting the security of travel, such as terrorist acts, armed conflict and threats thereof, acts of piracy, and
other international events; the risks and
increased costs associated with operating internationally; our expansion into and investments in new markets; breaches in data security or
other disturbances to our information technology and
other networks; the spread of epidemics and viral outbreaks; adverse incidents involving cruise ships; changes in fuel prices and / or
other cruise operating costs; any impairment of our tradenames or goodwill; our hedging strategies; our inability to obtain adequate insurance coverage; our substantial indebtedness, including the ability to raise additional capital to fund our operations, and to generate the necessary amount of cash to service our existing debt; restrictions in the agreements governing our indebtedness that limit our flexibility in operating our business; the significant portion of our assets pledged as collateral under our existing debt agreements and the ability of our creditors to accelerate the repayment of our indebtedness; volatility and disruptions in the global credit and financial markets, which may adversely affect our ability to borrow and could
increase our counterparty credit risks, including those under our credit facilities, derivatives, contingent obligations, insurance contracts and new ship progress payment guarantees; fluctuations in foreign currency exchange rates; overcapacity in key markets or globally; our inability to recruit or retain qualified personnel or the loss of key personnel; future changes relating to how external distribution channels sell and market our cruises; our reliance on third parties to provide hotel management services to certain ships and certain
other services; delays in our shipbuilding program and ship repairs, maintenance and refurbishments; future
increases in the price of, or major changes or reduction in, commercial airline services; seasonal variations in passenger fare rates and occupancy levels at different times of the year; our ability to keep pace with developments in technology;
amendments to our collective bargaining agreements for crew members and
other employee relation issues; the continued availability of attractive port destinations; pending or threatened litigation, investigations and enforcement actions; changes involving the tax and environmental regulatory regimes in which we operate; and
other factors set forth under «Risk Factors» in our most recently filed Annual Report on Form 10 - K and subsequent filings by the Company with the Securities and Exchange Commission.
Further strain is put on us every year because the state law known as the Triborough
Amendment obliges us to keep giving «step» salary
increases and
other generous benefits even when a labor contract has expired.
The
amendment would redirect funding for the bus program to a separate program controlled by the Department of Transportation, which Katko said would «wreak havoc» on the country's most used transit agencies without providing
increased funding certainty to agencies in
other states.
The
amendments increase penalties for «public justification of terrorism» online and penalize «inducing, recruiting, or otherwise involving»
others in mass unrest.
During the Equality Act 2010's passage through Parliament, we worked closely with a range of organisations as well as our supporters in Parliament to have
amendments made to the Equality Bill which sought to
increase protection against discrimination for humanists and
others, and to minimise the exceptions from the law granted to religious organisations.
There are four
other propositions on the June 5 primary ballot, including state constitutional
amendments about how to spend money from the state's recent gas tax
increase and cap - and - trade fees.
Smith said his 15 - word
amendment, co-authored by Majority Leader Eric Cantor (R — VA), would cancel a 6 %, $ 15.3 million
increase requested by the Obama administration for NSF's social, behavioral, and economic sciences (SBE) directorate and move the money into four
other NSF research directorates that Smith feels are more deserving.
The Senate bill adopted
amendments for school library investments, restoration of grant programs in Indian Country for teacher training and student fellowships, and
increased equity in school sports, among
others.
The 1997
Amendments to IDEA contain new regulations about sending students to alternative educational settings for drugs, weapons, or «substantial evidence that maintaining the current placement of the child is substantially likely to result in injury to the child or to
others...» (Section 300.521) As a result, the number of students in alternative programs could
increase.
The committee opposed multiple
amendments seeking to
increase funding allocations for Title I, Head Start, school counseling, arts education and several
other important education programs.
This
amendment was created by Senator Cooper and adopted by the state senate by a vote of 19 - 11, and provided $ 5.9 million for what is called «external cost adjustment,» which «
increases salaries by taking into account inflation and
other cost pressures, for K - 12 professional staff members,» according to Wyoming news source, the Casper Star Tribune.
The Certificate of Incorporation was adopted at a time when no
other voting securities of the Company were outstanding, and although the Series B Preferred Stock generally votes on an as if converted basis together with the Common Stock, the Certificate of Incorporation does not expressly deal with the voting rights of the Series B Preferred Stock in the context of the «opt out» provision relating to
amendments to
increase authorized stock.
Therefore, the
amendments to the CLC include, among
other things,
increasing the maximum length of parental leave to 63 weeks, extending the period prior to the estimated date of birth when the maternity leave may begin to 13 weeks, and creating leaves for an employee to take care of a critically ill adult family member and a to take care of a critically ill child.
Seeing an
increase in the presence of trademarks in a language
other than French displayed on outdoor signage all over the province, the Québec Minister of Culture and Communications and Minister Responsible for the Protection and Promotion of the French Language, Hélène David, tabled proposed
amendments to regulations under the Charter of the French Language (Loi 101).
If, in respect of expenditure
other than that necessarily resulting from this Treaty or from acts adopted in accordance therewith, the actual rate of
increase in the draft budget established by the Council is over half the maximum rate, the European Parliament may, exercising its right of
amendment, further
increase the total amount of that expenditure to a limit not exceeding half the maximum rate.
This paragraph goes a long way to ensuring that the Sixth
Amendment rights championed in the Apprendi - Blakely line of cases are not going to avail many defendants in
other sentencing settings in which judges have been given broad authority to conduct fact - finding to
increase sentences.