And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and
other animal models at the University of Washington.
Not exact matches
«Before our work in rhesus monkeys, it has not been possible to detect or observe some of these symptoms in
other HD
animal models, especially emotional dysregulation,» says senior author Chan, associate professor of human genetics
at Yerkes National Primate Research Center and Emory University School of Medicine.
Still, he says,
other groups have arrived
at opposing results regarding the role of T cells in the disease, in part, perhaps, because their
animal models aren't the same.
In five
other studies published over the past year, Taffe, Dickerson and their laboratories have looked
at the effects of MDPV and a related «bath salts» cathinone derivative, mephedrone, in a range of
animal models.
If the findings of the study are replicated in
other animal models, such as pigs, they could have considerable implications for public health, says Oluf Pedersen, professor of genomic medicine
at the Novo Nordisk Foundation Center for Basic Metabolic Research
at the University of Copenhagen.
Bearden says she and her team are collaborating with
other scientists to investigate brain structural differences in
animal models, to find out what causes them
at the cellular level.
(
At the
other extreme,
animals such as horses, who have a long gestation and then walk almost immediately after they are born, also fit the
model.)
Kohn and his former student Cecile Beguin selected four of these compounds and synthesized them along with five
other analogs to evaluate in
animal models at the National Institutes of Health (NIH).
«We know from
animal models that there are critical periods during early development when cells are rapidly dividing and forming the circuitry through which cells will communicate with each
other to form various tissues of the body,» said Retha Newbold, a reproductive biologist
at the National Institute of Environmental Health Sciences in North Carolina.
«The development of this microfluidic lung
model, as well as
other organs - on - chip, holds the promise of improving the physiological relevance of cellular
models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of
animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist
at RTI and the project's principal investigator.
There's more to these findings than just lofty philosophical quandaries, though: If ravens really do possess a level of social cognition comparable to humans and
other large primates, the birds might serve as better
animal models to study this kind of behavior in the lab — which could help scientists understand why some humans are better
at this kind of inference than
others, and why some individuals can't manage it
at all.
Subsequently, work in the Markou laboratory showed that these compounds had desirable effects on nicotine dependence in
animal models, while offering a better side - effect profile than
other alternatives under study (full agonists
at the same receptors).
SAN FRANCISCO, CA — Scientists
at the Gladstone Institutes have discovered that an FDA - approved anti-epileptic drug reverses memory loss and alleviates
other Alzheimer's - related impairments in an
animal model of the disease.
If we equate de facto ketogenic diets with high - protein diets (which is not always correct) then the risks proposed by critics of this type of dietary approach are essentially those of possible kidney damage due to high levels of nitrogen excretion during protein metabolism, which can cause an increase in glomerular pressure and hyperfiltration.12 There is not wide agreement between studies; however, some infer the possibility of renal damage from
animal studies, 99, 100 whereas
others, looking
at both
animal models, meta - analyses and human studies, propose that even high levels of protein in the diet do not damage renal function.101, 102 In subjects with intact renal function, higher dietary protein levels caused some functional and morphological adaptations without negative effects.103 There may actually be renal - related effects, but on blood pressure rather than morphological damage.
The AVMA has drafted
model legislation that, if enacted, would actually improve the welfare of dogs
at breeding facilities,
animal shelters, retail pet stores and
other types of operations,» said Dr. Ron Dehaven, the AVMA's chief executive officer.
Staff
at the Best Friends Sanctuary, where many of Michael Vick's dogs were sent after their rescue, have stated that when Mya first arrived
at the sanctuary, she was «afraid of her own shadow,» but has since blossomed into her role as a puppy socialization
model, helping younger dogs to settle into their new lives and become comfortable around
other animals.
Opening: «Eduardo Sarabia: Ballads»
at Other Criteria Combining decorative art objects with motifs referencing the Mexican and Mexican - American drug scene — ranging from guns, skulls, and nude pin - up
models to marijuana leaves and
animals symbolizing specific illegal drugs — Eduardo Sarabia makes art from Narco culture.