Sentences with phrase «other animal models of»

After discussing similar effects in other animal models of cancer and a few studies showing the ability of antioxidants to prevent cancer growth, Campbell concluded that «a pattern was beginning to emerge: nutrients from animal foods increased tumor development while nutrients from plant - based foods decreased tumor development.»

This proposed role for GM1 (and indirectly GD1a) provides a rationale for its potency in suppressing diabetes in NOD mice (10) and disease onset in other animal models of autoimmunity.

They found that, within the first three days of injury, fish in the concussion group were slower to find a school of fish with which they previously swam, a measure of spatial memory which is impaired in other animal models of concussion and human patients.

They also stopped making new brain cells, something that has also been seen in other animal models of depression.

Not exact matches

10 There is no animal model of SIDS and it has never been observed to occur naturally in any species other than humans.2 While the standardization of a SIDS diagnosis has been and continues to be elusive and / or inconsistent, it is most often applied to situations in which an otherwise healthy infant between the ages of 8 - 16 weeks, especially, but up to 12 months, dies suddenly and unexpectedly presumably during its sleep and upon postmortem examination no apparent internal causal factor (s) explaining the death can be identified.11, 12

New research from McLean Hospital neuroscientists shows in an animal model that being bullied can have long - term, dramatic effects on sleep and other circadian rhythm - related functions, symptoms that are characteristic of clinical depression and other stress - induced mental illnesses.

«Before our work in rhesus monkeys, it has not been possible to detect or observe some of these symptoms in other HD animal models, especially emotional dysregulation,» says senior author Chan, associate professor of human genetics at Yerkes National Primate Research Center and Emory University School of Medicine.

Other projects aimed to show that animals have a theory of mind, the ability to model the thinking of others (as when we judge whether a poker player is bluffing or if a potential mate is truly in love).

Still, he says, other groups have arrived at opposing results regarding the role of T cells in the disease, in part, perhaps, because their animal models aren't the same.

Importantly, the development of a new animal model for Dravet syndrome based on reduced CHD2 expression might help to find effective treatments that could improve the lives of thousands of people suffering from Dravet syndrome and perhaps other genetic epilepsies.»

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

He sees the capability of using the team's research in the future to design models that will help game managers, conservation managers, farmers and tour operators predict animal migration, whether it's zebras or other migratory animals.

And the trouble with extrapolating so much from mouse studies is that «nobody has actually shown over the long term how long these quote un-quote improvements persist, and we don't know whether it's broadly improving aspects of aging or it's specific to certain tissues,» said Matt Kaeberlein, a biologist who studies aging in dogs and other animal models at the University of Washington.

In five other studies published over the past year, Taffe, Dickerson and their laboratories have looked at the effects of MDPV and a related «bath salts» cathinone derivative, mephedrone, in a range of animal models.

The researchers now plan to test this type of insulin in other animal models and are also working on tweaking the chemical composition of the insulin to make it even more responsive to blood - glucose levels.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

«Mature B lymphocytes accelerate the healing of diabetic ulcers, other skin injuries: Direct application of immune cells speeds and improves healing of acute and chronic wounds in animal models.»

In past studies to develop a new animal model for the brain events that support motor development, neurophysiologist Martin Garwicz of Lund University in Sweden and his colleagues discovered that the schedules by which ferrets and rats acquire various motor skills, such as crawling and walking, are strikingly similar to each other; the progress simply happens faster for rats.

If the findings of the study are replicated in other animal models, such as pigs, they could have considerable implications for public health, says Oluf Pedersen, professor of genomic medicine at the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen.

But this remarkable therapeutic benefit isn't limited to MS. Previous research in animal models that mimic other diseases suggest that certain forms of amyloids can ease damage from strokes, traumatic brain injuries and even heart attacks.

It's not clear what would happen to the rest of NCRR's portfolio, which includes support for construction and instrumentation, primate centers and other model animal resources, and grants for minority institutions and states that don't have much NIH funding.

The scientists said they are currently working on analyses to model the ecological role that nonhuman primates play in maintaining the diversity of astroviruses, particularly in places where they share the environment with humans and other animals.

The insects and other animals that frequent milkweed form a model community for the study of interactions among species.

Kohn and his former student Cecile Beguin selected four of these compounds and synthesized them along with five other analogs to evaluate in animal models at the National Institutes of Health (NIH).

The decision follows recommendations from an NIH advisory panel that said in January that the agency should curb research on chimps and instead «emphasize the development and refinement of other approaches, especially alternative animal models,» and move all but approximately 50 of the chimps to sanctuaries.

Using a mathematical model that combines a huge number of cattle and badgers that have TB, the researchers were able to quantify the relationship between the two animals and use a big data approach to show that the route of infection for cattle is from other cattle rather than from other species.

The engineered T cells also performed successfully in a mouse model of PV, killing desmoglein - specific B cells and preventing blistering and other manifestations of autoimmunity in the animals.

Though the scientists don't know if such individual and pack behavior is a common occurrence, observations like these on Isle Royale provide insight into how animal societies function as well as the vicissitudes of the food chain cycle on Isle Royale, also helping to inform other models of the natural world.

University of Adelaide researchers in Australia, supported by the Invasive Animals Co-operative Research Centre, have developed a model of the likelihood of establishment of alien species of snakes and other reptiles if they are introduced to the wild, accidentally or on purpose.

«We know from animal models that there are critical periods during early development when cells are rapidly dividing and forming the circuitry through which cells will communicate with each other to form various tissues of the body,» said Retha Newbold, a reproductive biologist at the National Institute of Environmental Health Sciences in North Carolina.

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

The zebrafish's transparency, small size, and rapid reproduction make it one of the best models for studying how animals and bacteria «talk» to each other, she adds.

In collaboration with the United States Department of Agriculture (USDA), researchers in the UPV / EHU's «Nutrition and Obesity» Group, which belongs to the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn) of the Carlos III Institute of Health, have observed in animal models that its administration reduces the build - up of body fat, which could reduce the risk of developing other diseases like diabetes.

The initial results of the cow study, showing that people do empathize with the animal, indicate that the same model could be useful in other experiments, he said.

«The development of this microfluidic lung model, as well as other organs - on - chip, holds the promise of improving the physiological relevance of cellular models for more accurate prediction of the effects of toxicants and drugs on humans, and for reducing the use of animals in medical and pharmaceutical research,» said Sonia Grego, Ph.D., research scientist at RTI and the project's principal investigator.

In the case of influenza, mAbs have been shown to provide prophylactic or therapeutic protection in mice and other animal models (Reuman et al., 1983; Sweet et al., 1987; Palladino et al., 1995; Renegar et al., 2004).

The researchers» strategy — generating disease - specific nerve cells, identifying a causative gene for developmental defects, validating the gene - specific defect in animal models, and then investigating interactions with other genes both in animal models and in humans — represents a promising new approach for understanding the mechanisms underlying some of the most intractable psychiatric illnesses.

PBPK modeling is used in pharmaceutical research and development and in health risk assessment to predict the absorption, distribution, metabolism and excretion of a compound in humans and other animal species.

Additionally, the wheel lock and other animal model suggest that exercise during youth may help preserve muscle mass over the course of aging and lower the activity of genes associated with cardiovascular disease.

The UCSF TCORS also has two developmental projects — one on risk perceptions of smoking by older Americans, and another to develop better animal models of the cardiovascular effects of secondhand smoke and exposure to other tobacco products, said Glantz.

Similar findings were present in the cerebral cortex and other regions of the brain in these animals and also found in several other mouse models of diabetes.

Such models are valuable for the analysis of parameters associated with vaccine safety, immunogenicity, delivery and protection as NHPs replicate key features of the human immune response more faithfully than any other animal model.

Here we used our knowledge of the developmental biology of many other animal models to provide the positive and negative signaling factors to guide the developmental choices of these tissue and organ stem cells.

Animal gait is affected in models of human disorders such as Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, spinal cord injury and many others.

The Carnegie Mellon University researchers, who have worked with Goldman on relating the locomotion of other animals to robots, demonstrated that theoretical models developed to describe the complex motion of robots can also be used to understand locomotion in the natural world.

Dean LaFerla has several research interests, including the molecular biology of Alzheimer's disease and other neurodegenerative disorders, presenilins and calcium signaling, learning and memory, and transgenic and genetically modified animal models.

While some scientists believe there was indeed an explosion of diversity (the so - called punctuated equilibrium theory elaborated by Nils Eldredge the late Stephen J. Gould - Models In Paleobiology, 1972), others believe that such rapid acceleration of evolution is not possible; they posit that there was an extended period of evolutionary progression of all the animal groups, the evidence for which is lost in the all but nonexistent precambrian fossil record.

There's more to these findings than just lofty philosophical quandaries, though: If ravens really do possess a level of social cognition comparable to humans and other large primates, the birds might serve as better animal models to study this kind of behavior in the lab — which could help scientists understand why some humans are better at this kind of inference than others, and why some individuals can't manage it at all.

We have learned a fair amount from the neurologic genetic diseases, but we and others also studied these cells in the laboratory as well as in animal models of brain injury.

They may be used to understand normal or abnormal structure and function or determine the efficacy of treatments where no other suitable animal models exist.