If the immune system evolved alongside social behavior, this might explain the results of
other autism studies.
Not exact matches
Jiang said
autism researchers worldwide could use the mouse model to
study ways to compensate for the gene and improve symptoms in people with
autism spectrum disorders and Phelan - McDermid Syndrome, a more profound developmental condition caused by mutations to SHANK3 and
other genes in chromosome 22.
In the heady postwar years, hundreds of promising
studies were conducted in the United States, Canada, and Europe on the use of LSD and
other psychedelics, like peyote, to treat such psychiatric maladies as schizophrenia,
autism, drug addiction, alcoholism, and chronic depression.
Studies have shown that if one identical twin has
autism, there is at least a 60 percent chance that the
other also does.
«Not only can people with
autism socialize more under the effect of oxytocin, they can understand the behaviors of
others and respond accordingly,» explains
study co-author Angela Sirigu, director of research at the Center for Cognitive Neuroscience in Bron, France.
The largest of its kind, the
study examined genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing risk for schizophrenia have previously been associated with
other neurodevelopmental disorders, including intellectual disability and
autism spectrum disorders.
In a
study published earlier this year, Jiang and
other collaborators at Duke described a mouse model of
autism in which they deleted a prominent
autism gene called SHANK3, which is mutated in 1 percent of people with the disorder.
Scientific American reported in 2009 that a joint U.S. / Swedish
study looking into the effects of household contaminants discovered that children who live in homes with vinyl floors — which can emit hazardous chemicals called phthalates — are twice as likely to develop signs of
autism as kids in
other homes.
Children with
autism have no unique pattern of abnormal results on endoscopy or
other tests for gastrointestinal (GI) disorders, compared to non-autistic children with GI symptoms, reports a
study in the Journal of Pediatric Gastroenterology and Nutrition (JPGN), official journal of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.
At Dr Falk's laboratory, the method is used to also
study other congenital diseases that affect the brain, such as
autism and Down syndrome.
The implications of obesity have also been a topic of interest, including
studies of a potential link to
autism for children born to diabetic and obese mothers and
other research that indicates obesity as a possible risk factor for cognitive decline.
The
study, which has identified more than 200 rare variants inherited by children, determines that genes YWHAZ and DRP2, among
others, are new candidates in the research on
autism genetic basis.
The team anticipates future
studies could leverage data from the Environmental Protection Agency and
other sources to identify links between specific environmental causes and increased rates of
autism and ID.
And there is
other evidence for a vitamin D link: Last November, Cornell University researchers published a
study in Archives of Pediatrics & Adolescent Medicine showing that children in rainy (and therefore more overcast) counties of Oregon, Washington and California were two times more likely to be diagnosed with
autism than their counterparts in drier parts of the state.
«It's enough to make me think about trying it in a few of my
autism patients who haven't responded to
other interventions,» says Randi Hagerman, a pediatrician who
studies neurodevelopmental disorders at the University of California, Davis.
«If we find that we are able to reduce the recurrence rate of
autism within families substantially enough,
others will want to
study this in larger groups with larger controls.»
Other Stanford authors of the
study are research assistants Charles Lynch, Katherine Cheng, Paola Odriozola and Maria Barth; Jennifer Phillips, PhD, clinical associate professor of psychiatry and behavioral sciences and co-director of the
Autism and Developmental Disabilities Clinic at Lucile Packard Children's Hospital Stanford; Carl Feinstein, MD, professor emeritus of psychiatry and behavioral sciences; and Daniel Abrams, PhD, postdoctoral scholar.
With the right incentive, such as winning a prize, children with
autism do fairly well at inferring the thoughts and beliefs of
others, according to a new
study
Interestingly, the authors noted that since the
study showed that microbiota in the gut can influence the brain, it «adds to evidence suggesting that the intestinal microbiota may play some role in the spectrum of brain disorders ranging from mood or anxiety to
other problems that may include
autism, Parkinson's disease and multiple sclerosis.»
«The findings may help researchers evaluate the effects of different
autism therapies,» said Kaustubh Supekar, PhD, a research associate and the
other lead author of the
study.
Some of the children in the
study probably have
autism,
others have symptoms that mimic
autism, but are not really due to
autism.
A
study to be published in the April 2016 issue of the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP) reports that eye tracking can differentiate children with
autism spectrum disorder (ASD) from children without ASD but with
other developmental problems (non-ASD).
A new
study, published online in Pediatric Neurology, evaluated children with TSC, which causes malformations and tumors in the brain and
other vital organs and has a high prevalence of
autism spectrum disorders (ASD).
Together with Drs. Ami Klin and Warren Jones, Moriuchi
studied how 86 two - year - old children with and without
autism paid attention to
other people's eyes.
The authors» method of analyzing connectivity could also be used to
study other disorders, such as schizophrenia,
autism, or dementia, she says.
Even though the primary results of a related
study investigating the effects of music therapy with children with
autism, do not show that music therapy works better than
other therapies, subgroup analysis identified that children with childhood
autism or coexisting intellectual disability improve to a greater extend from music therapy than children with another
autism diagnosis.
Independent means of transportation contributes to
other long - term opportunities, such as post-high school education or employment and being socially involved and connected within their community,» says Benjamin Yerys, PhD,
study co-author and a scientist at the Center for
Autism Research (CAR) at CHOP.
Gabrielsen, an assistant professor in BYU's Counseling Psychology & Special Education department, and Miller, who is now at the Center for
Autism Research at the Children's Hospital of Philadelphia, worked on the
study with four
other researchers.
The
study may explain, among
other things, how the mother's infection with the cytomegalovirus (CMV) during pregnancy, which affects her own and her fetus's immune system, increases the risk that her offspring will develop
autism or schizophrenia, sometimes years later.
Other large NIH - and EPA - funded
studies are teasing out immune abnormalities that may contribute to
autism.
In a
study recently published online in the Journal of
Autism and Developmental Disorders, the researchers found that mothers of teenagers with ASD or ID reported higher levels of stress and
other negative psychological symptoms — think depression or anxiety — than mothers of teenagers with typical development, or TD.
In the new
study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in
autism and several
other psychiatric disorders.
The new
study will focus on four areas of high public health concern: obesity, birth defects and
other early outcomes, neurodevelopmental disorders (such as
autism and depression), and airway diseases (such as asthma and allergies).
Last year, for example, a Centers for Disease Control and Prevention
study of thousands of children with developmental disabilities found that kids with
autism were twice as likely as children with
other types of disorders to have frequent diarrhea or colitis, an inflammation of the large intestine.
Future
studies should help to reveal more about the role of the many genes and mutations that contribute to
autism and
other disorders, Feng says.
Her research group will continue to
study these proteins and the role they play in neural development and fragile X syndrome — work that's likely to influence
other fields of inquiry in
autism and beyond.
For instance, some of the genetic alterations found in the
study occurred in families with one person severely affected by
autism and
others on the milder end of the spectrum, Dr. Scherer notes.
In their new
study, the investigators went even further — looking beyond DNA «spelling» variations to find
other types of genetic changes associated with
autism.
Matthew Anderson, a physician - scientist at Beth Israel Deaconess Medical Center and Harvard Medical School in Boston, Massachusetts, says that the
study will encourage
other researchers to explore metabolic pathways as causes of
autism.
The excess was greater within DL - PFC than in M - PFC, a difference that parallels MRI volumetric data showing greater deviance in DL - PFC than M - PFC in living autistic toddlers.6 MRI
studies show that enlargement is not restricted to DL - PFC and M - PFC; whether increased neuron counts in
autism extend beyond these 2 major prefrontal subdivisions to include
other cortical areas remains to be determined.
But while the risks reported in the
study pale in comparison to some hereditary factors, Hertz - Picciotto said they are comparable to
other risks for
autism, such as advanced parental age or not taking prenatal vitamins.
Published this week in the journal Nature, the
study reveals the earliest sign of developing
autism ever observed — a steady decline in attention to
others» eyes within the first two to six months of life.
«This
study entertains the possibility that probiotic treatment can be beneficial in «restoring» certain behaviours in
autism and
other neurodevelopmental conditions, based on experimental evidence in rodents.
«Instead of looking solely at the genes directly implicated in
autism through their genetic code changes, we really should be also
studying the functions of the
other genes implicated by these changes in genetic code through epigenetic connections.»
During the clinical component of the course — which delves into pathology, or the
study of disorders / diseases in bodily tissues — he was struck by how there's no physical sign of what's wrong in
autism, schizophrenia, bipolar disorder, and
other maladies of the nervous system.
Gladstone Senior Investigator Nevan Krogan, PhD, is
studying how the proteins in neurons interact with each
other and how mutations in the proteins lead to
autism.
One 2016
study led by UCLA scientists found that siblings with
autism seldom share the same genetic variations, and
other studies suggest that, in many cases, troubling mutations found in the child are not found in either parent.
We have also made contributions to the
study of
other complex diseases, including breast cancer, melanoma, oral clefts, eye disorders, Chiari malformation, ADHD and
autism.
«Because big genetic
studies have been done on schizophrenia and
autism and
other diseases, you can calculate someone's risks of developing those diseases from their genetic information and you can see if it's associated with contagious yawning,» she said.
Although difficulty in understanding of
others» social emotions and beliefs under conditions without direct emotional cues also plays an important role in
autism spectrum disorder, no
study has examined the potential effect of oxytocin on this difficulty.