Sentences with phrase «other breast cell»

When Sukumar and the others depleted the HOXA5 protein in other breast cell lines in the lab, the cells became more immature, or «stem like,» as well as more mobile.

Not exact matches

Hindmilk, on the other hand, is the creamy milk with higher fat content that is stored in the milk - making cells located higher up in the breast, and helps stimulate your baby's growth.

As the breast fills, compounds in the retained milk (FIL, peptides, fatty acids, and other components) signal the secretory cells to slow down milk synthesis.

The stimulus of nursing or suckling supports continued lactation in two ways: it promotes the secretion of prolactin (and possibly other pituitary hormones of value in milk formation), and it triggers the release of yet another hormone from the pituitary gland — oxytocin, which causes contraction of special muscle cells around the alveoli in the breast and ensures the expulsion of milk.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

Use your MheartM in your Sarah Wells breast pump bag to organize your wallet, keys, cell phone and other accessories, and then «grab and go» when you don't need to take your full - size breast pumping tote with you.

Breast milk contains antibodies and other cells that boost your baby's immune system, making them less likely to get sick.

They found that particular cells in the breast must remain insulin sensitive to develop properly and function in the presence of other hormones of lactation.

«We feel it'll be able to help kill cancer cells in 80 percent of breast cancer patients,» said Dr. Olson, who added that their antibody has the potential to help kill lung, colon, prostate and other cancer cells, too.

Breast cancer tumors can fuse with blood vessel cells, allowing clumps of cancer cells to break away from the main tumor and ride the bloodstream to other locations in the body, suggests preliminary research.

In the Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models of breast and lung cancer — two tumor types that often spread to the brain — many cancer cells that enter the brain are killed by astrocytes.

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

The researchers studied triple - negative breast cancer cells, which grow and spread faster than most other types of cancer cells.

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cells.

Stem cells from breast milk can grow into many other kinds of human tissue, raising hopes of an ethical source of embryonic - like stem cells

Still, how melanoma cells join into tumors — whether by individual cells coming together or small or large clusters of cells doing so — follows the same pattern as breast tissue cancer cells: Cables are extended to reel in other cells or clusters.

Using this biosensor in highly invasive breast cancer cells taken from rodents and humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.

However, along with this seemingly linear storyline in which retinoids block progesterone's promotion of CK5 + cells, previous work in the lab of CU Cancer Center investigator Peter Kabos, MD, and others shows that breast cancers treated with anti-estrogen drugs like tamoxifen or aromatase inhibitors show an increased population of CK5 + cells — it is as if these therapies remove the roadblock of estrogen - dependent cells, leaving CK5 + cells to proliferate.

The data that the breast cancer cells spread more successfully in clumps are compelling, D'Souza - Schorey said, but no one yet knows whether cells from other types of cancer also need help to migrate.

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

Then the researchers turned to the lab, where they exposed human liver, breast, colon, ovarian, and other cancer cells to the drugs, which appeared to make it easier for the cells to migrate.

Working with human breast cancer cells and mouse models of breast cancer, scientists identified a new protein that plays a key role in reprogramming cancer cells to migrate and invade other organs.

The primary cause of death from breast cancer is the spread of tumor cells from the breast to other organs in the body.

Interferon - inducible protein 6 - 16 (IFI 6 - 16), a protein not previously known to be associated with other misfolding diseases but that was uniquely found misfolded in the urine of women with preeclampsia, is known to help prevent cell death and, in breast cancer cells, is responsible for resistance to treatment.

The importance of these neighbour proteins was also seen in other networks constructed for breast cancer, hepatocellular carcinoma and non-small cell lung cancer, other «solid» cancers where new drugs are needed to tackle high mortality rates.

«Triple - negative breast cancer cells are highly mobile in the body, which helps them metastasize to other organs throughout the body,» Hyder said.

According to Bolton, 8 - PN showed only a slight increase of metabolism in breast cells, while the other two compounds did not have significant effects in either cell line.

In particular, it has been shown that cells with other HR repair pathway defects, such as BRCA mutations frequently found in breast and ovarian cancer, are sensitive to inhibition of the enzyme PARP, and the PARP inhibitor Olaparib has been approved for treatment of BRCA - mutated ovarian cancers.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

This shows promise for breast cancer patients as diagnosing and treating the breast cancer at early stages means there is a greater chance of preventing cancer cells spreading to other tissues, such as the lungs, brain and bone.

Other studies have found that nutrients in dark, leafy greens may inhibit the growth of tumor cells in breast, skin, lung and stomach cancers and that green tea may thwart cancer development in colon, liver, breast and prostate cells.

They work particularly well if the cancer cells they attack already have defects in the corresponding DNA repair pathways, as it frequently occurs in breast cancer and other tumors.

And if fetal cells protect women from breast cancer, they might also safeguard against other tumors.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

In other experiments designed to determine how PTPD2 operates in HER2 - activated breast cancer cells, the team found an «interaction partner,» a lipid called phosphatidic acid, or PA..

They tried AMP, an organic compound found in breast milk and other substances, that is created as cells break down food.

Singletary added sulforaphane, a chemical in broccoli, kale, brussels sprouts, and other cruciferous vegetables, to cultures of human breast cancer cells.

Previous in vitro studies conducted by researchers in other countries showed that this molecule was able to reduce the multiplication and increase the mortality of cells from melanoma, the most aggressive type of skin cancer, as well as breast cancer and neuroblastoma, a tumor that typically affects patients aged 15 or younger.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.

The treatment is promising enough that research teams around the world are developing similar stem cell therapies that can target and eradicate cancers of the prostate, lung, breast, skin and other tissues.

Breast cancer cells lacking ROBO1 were more invasive, suggesting that the upregulation of ROBO1 in stiff environments may prevent cells from metastasizing to other tissues.

«We note that there are two subgroups of breast tumors by epigenome: one which we have called Epi - Basal, characterized by loss of epigenetic marks causing breakage of chromosomes and the other that we have called Epi - Luminal B, that presents epigenetic inactivation of genes that should protect us from cancer and these altered cells can no longer do it.»

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

Exosomes and other extracellular vesicles (EVs) are small membrane vesicles containing protein, messenger RNA, microRNA, DNA, and lipids, which are secreted by various cells and are stable in body fluids including blood, saliva, urine, cerebrospinal fluid, and breast milk.

The team found evidence of the process in several other cell types, including breast, ovarian, umbilical cord, and kidney cancer cells.

The mechanism is known as NMD (nonsense - mediated mRNA decay), and scientists found that exposing breast cancer cells to a molecule that inhibits NMD prior to treatment with doxorubicin, a drug used to treat leukemia, breast, bone, lung and other cancers, hastens cell death.

The team also found that these genes had different functions in promoting metastasis: One group encouraged growth of tumor cells in both breast and lungs, whereas the other only helped the new tumor thrive in the lungs.

On the other hand, overexpression of miR7 significantly decreased the mammosphere - forming ability of primary breast tumor cells (Fig. 5D).

The example shown reveals that these estrogen agonists show the strongest connectivity to each other in MCF7, a human breast cancer cell line that expresses the estrogen receptor.