Sentences with phrase «other cancer»

CRI: What's the advantage of immunotherapy over other cancer therapies?

Additionally, the compound they have developed allows them to profile other cancer types and see if they are dependent on BFL - 1 for their survival.

University of California San Francisco researchers may have discovered why the experimental anti-cancer drug Onyx - 015 works more broadly than had been expected, a finding that could solidify and expand use of the drug and which reveals a potential new target for therapy that could prompt the development of other cancer drugs.

Here's a sample of other cancer news blowing in the Windy City and beyond this week.

The company is developing CAR T - cell immunotherapies for multiple myeloma, prostate and other cancer types, as well as gene therapies for orphan diseases.

A Phase 1b / 2 Open - Label Study to Evaluate Safety, Clinical Activity, Pharmacokinetics and Pharmacodynamics of Avelumab (MSB0010718C) in Combination with Other Cancer Immunotherapies in Patients with Advanced Malignancies

In addition, the study, led by investigators in The Cancer Genome Atlas (TCGA) Research Network, revealed four novel tumor subtypes, while also identifying genomic similarities between endometrial and other cancer types, including breast, ovarian, and colorectal cancers.

Radiation can treat tumors that can not be removed by surgery (sometimes shrinking them enough to be operable) and can be used to relieve pain and other cancer symptoms.

CRI: Can CAR T cells be engineered to go after any cancer marker, such as NY - ESO - 1 or other cancer antigens?

Ovarian cancer accounts for 5 % of cancer deaths among women and causes more deaths than any other cancer of the female reproductive system.

But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance.

The incidence of malignant melanoma has increased in recent years more than that of any other cancer in the United States.

For example, HPV - inactive tumors were 17 times more likely to contain TP53 gene mutations — which are common in other cancer types — than HPV - active cervical cancers.

«What we think this might mean is that these de novo, new, genetic changes may be more relevant to early onset cancers with an impact on fertility,» says Stadler, since testicular cancers more often occur during reproductively active years than the other cancer types.

When studying how normal cells change into cancer cells, dos Santos and other cancer researchers pay close attention to gene expression.

«The next step of our work will see how this approach works in other cancer types, and we hope it could ultimately lead to testing this technique in trials to see if it can help patients.»

At the meeting, Tomas Walsh of the University of Washington, Seattle, reported on a test he and King developed, called BROCA, that sequences not only the BRCA genes, but also about 38 other cancer risk genes.

The researchers» study also found that, compared with patients with other cancer types, patients with breast cancer were 3.7 times less likely to develop PTSD at six months, but not at four years.

A third team, led by molecular geneticist Joshua Mendell at Johns Hopkins University School of Medicine in Baltimore, Maryland, wondered if the same set of seven microRNAs could turn other cancer - promoting genes on or off.

The gene has also been shown to synergize with other cancer treatments.

Most importantly, the combination resulted in no added toxicity for the recipients, unlike many other cancer treatments.

The sugar intake from sugar - sweetened beverages among women with cervical cancer history was much higher (60g / day) compared to other cancer survivors who consumed only around 30 - 40 g / day.

Confirmation of the biomarkers in other cancer types will facilitate further characterization and validation to provide mechanistic understanding of how and why these specific gene - targets become modulated to accentuate or inhibit tumor metastasis.

Finally, the researchers showed that the circuit could be readily converted to target other cancer cells.

To explore this idea, Hopkins oncologists Dung Le, Luis Diaz, and others looked for mismatch repair mutations in tumor samples from patients with advanced colon cancer and other cancer types whose tumors had stopped responding to other treatments.

«We would also like to determine if this combination is effective against other cancer types.»

The researchers» next steps will involve expansion of the biomarkers identified in this study to other cancer types, especially breast cancer, due to the hormonal input that is a common factor in gynecologic tumors.

Following the ovarian cancer analysis, the team expanded the study to include other cancer types.

Every woman in Sweden who receives BRCA testing is now also offered the chance to sign up for a study in which she's tested for 63 other cancer genes.

«We will then use this technique to explore prostate tissues from other cancer patients.

In contrast to other cancer - promoting genes, CtBP is not mutated in colon cancer; instead, it is overexpressed to the point where the cancer depends on it for growth.

For this purpose, the researchers used the computational tool IMPACT, developed in the Tan lab, to sort functional from missense mutations and to cross-reference candidate mutations with those previously reported in other cancer types.

Cells are relatively protected when they are attached to other cancer cells and their surroundings, but become more vulnerable when they detach and «float», and normally undergo cell death.

«While there is understandable excitement around new therapies that enlist the immune system to fight cancer, we are still in a situation where greater than half of patients don't respond in melanoma and the response rate is even worse in other cancer types,» Hanks said.

Using genetic tools to establish in which cells cancer - driving mutations originated and then propagated into other cancer cells, they demonstrated that a distinct and rare subset of MDS cells showed all the hallmarks of cancer stem cells, and that no other malignant MDS cells were able to propagate the tumour.

In an era of precision medicine, the guideline provides recommendations for pathologists, oncologists, and other cancer health professionals on the current state - of - the - art recommendations for the molecular testing of lung cancer.

«We need to understand more about what makes these cancer stem cells unique, what makes them different to all the other cancer cells.

The team also found that there were also cases of other cancer types in families with these hereditary mutations such as leukemias and brain tumours.

Fu plans to further explore the link between PLK1 and MAPK signaling in prostate cancer patients and determine whether PLK1 - induced EMT contributes to other cancer - promoting processes that go beyond cell migration and metastasis.

They also tested other cancer lines — human cervical, lung and prostate cancers — and found that they responded to the patterned tumor environments in the same way.

Avivi, meanwhile, is continuing to check for other cancer - killing chemicals that might be responsible.

In cases where a tumor had not doubled the mutated KRAS gene copy, the researchers discovered duplications in other cancer genes.

The discovery of EBV paved the way for the identification of other cancer - causing viruses, including human papillomavirus (HPV), and hepatitis B.

Interestingly, the only other cancer that showed a similar pattern was prostate cancer.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

Although insufficient on its own to trigger leukemia, f - circM9 appears to work together with other cancer - promoting signals (such as the MLL - AF9 fusion protein) to cause disease.

«These studies provide promising evidence that autophagy blockade can be achieved, and that combining autophagy inhibitors with other cancer therapies in very sick patients can be accomplished safely in most cases.

We suspect this strategy could benefit other cancer patient populations.»

Chemotherapy and other cancer treatments are supposed to get rid of the disease, but a new study finds they can elicit aggressive tumor growth instead, STAT reports today.

He and other cancer treatment researchers wanted to transport chemotherapy drugs inside a tumor after blocking its blood supply.