Sentences with phrase «other cancer genes»

The causative cancer gene variants are hiding in plain sight in these and other cancer genes, but the original testing laboratory didn't recognize them.

Every woman in Sweden who receives BRCA testing is now also offered the chance to sign up for a study in which she's tested for 63 other cancer genes.

In cases where a tumor had not doubled the mutated KRAS gene copy, the researchers discovered duplications in other cancer genes.

Not exact matches

The other, a former White House aide to President Obama, tested positive for the BRCA2 gene mutation that has led to breast cancer in her family for generations — and is taking aggressive steps to avoid the same fate.

The Kamens claim the main thing that distinguishes their foundation from other brain tumor foundations is their focus on pediatric brain cancer specifically, as well as their close ties with pharmaceutical and biotech companies working in the fields of immunotherapy and target gene therapy.

One of the key caveats at the time, however, was that the technique required the use of a virus to introduce several genes into the skin (or other) cell, and these would remain in the cell, and so might contaminate the resulting stem cell or create cancer risks.

Apparently broccoli contains potent nutrients which have the ability to switch «on» genes that prevent cancer development, and switch «off» other ones that help it spread.

Although she doesn't have a BRCA gene, Kati's cancer seems very similar to cancer that her maternal grandmother had and due to the way it has responded to treatment it is most likely related to other genetic factors.

If you have a strong family history of breast cancer or other cancers, your doctor may recommend a blood test to help identify specific mutations in BRCA or other genes that are being passed through your family.

Altered gene imprinting at other times has been associated with developmental disorders and cancer.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

«In addition, changes in how the genes are expressed (turned on or off) could be used in the future to predict how and when the cancer cells will spread to other parts of the body and how fast they will grow.»

Mutations in the genes that defend the body against cancer - related viruses and other infections may play a larger role in breast cancer than previously thought, according to a study at the University of Illinois at Chicago.

The discovery of the master gene that sends them into action promises a host of new treatments for infections, cancer and other diseases.

Other researchers have identified dozens of genes, all related to the growth and spread of cancer, that become over - or undermethylated when the disease gets under way.

Why some women get breast cancer and others do not is a mystery — genes are to blame for only about 1 in 10 cases.

The study also found that some of the morphing genes in the python's intestine, notably those in a signaling pathway called WNT, were genes that were involved in intestinal and other cancers.

Ostrander says that by identifying other dog genes for body size and for traits such as leg length and head shape, researchers may learn more about growth and its disorders — especially cancer — in humans and their best friends.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

«These particles, microRNA based SNAs, could also potentially be used for gene silencing in other cancers and diseases of genetic origin.»

«We'd like to extend this further to examine for driver genes in other types of lung cancer, such as squamous cell lung cancer.»

Inherited mutations of the tumour suppressor gene CDKN2A are the strongest known risk factors for familial melanoma and mutations in this gene also increase the risk of other cancers.

This gene is known to be highly active in multiple myeloma and many other cancers, raising the possibility that strategies to shut it down could be effective against a variety of tumors.

PARP inhibitors are used primarily to treat tumors linked to defects in BRCA genes, but may show promise in other cancers when combined with other drugs.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

They argue that anyone whose genome is sequenced for any medical reason should automatically learn whether 57 of their genes put them at risk of certain cancers, potentially fatal heart conditions, and other serious health problems.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

Under the new recommendations, the parents would learn not only if their child's heart condition is due to a particular gene mutation — they'd also learn whether she is at high risk of certain breast cancers, colon cancers, cardiomyopathies, aneurysms, and other diseases.

Vogelstein, Kenneth Kinzler, and other colleagues found a minor change in the APC gene, which normally holds cell growth in check and can cause colon cancers when mutated.

As the cost of gene sequencing drops, DNA being sequenced for one purpose may yield many other secrets, such as the risk of certain cancers and Alzheimer's disease.

For example, changes in certain genes could indicate that his cancer was more likely to respond to a particular drug, while other mutations might predict little benefit from a specific therapy.

The scientists have shown that, in all cancers, an aberrant activation of numerous genes specific to other tissues occurs.

Michele Carbone and colleagues, from the University of Hawaii, discovered that members of 4 families, apparently unrelated and living in different US States, shared the identical mutation of a gene called BAP1 that is associated with a higher incidence of mesothelioma, melanoma, renal carcinoma and other cancers.

This work provides a proof of principle for a new approach in the study and treatment of cancer: the aberrant expression in a tissue or organ of genes specific to other tissues could become a new tool for establishing a prognosis and personalizing therapeutic care.

Researchers from the Spanish National Cancer Research Centre (CNIO) have discovered more than 40 genes that predict the level of aggressiveness of melanoma and that distinguish it from other cancers with a poor prognosis.

Gene variants have been linked to elevated risks for disorders from Alzheimer's disease to breast cancer, and they may help explain why, for example, some smokers develop lung cancer whereas many others don't.

However, in the wake of fatalities from gene therapy and other technologies, as well as the potential for cancers associated with stem cell transplants, governments are understandably nervous about safety issues — not to mention the ethical maze of tinkering with fledgling life.

This question has been challenging to address experimentally because attempts to restore function to lost or mutated genes in cancer cells often trigger excess gene activity, causing other problems in normal cells.

Women with a family history of two or more immediate family members (mother, sister, daughter) with breast or ovarian cancer or with a positive genetic test for mutations in the BRCA1 or BRCA2 genes may be advised to consider having both breasts removed, because they are at high risk of a new cancer developing in the other breast.

The genes that affect hair colour also affect other cancer types, while other pigment genes affect the chances of having Crohn's and other forms of bowel disease.

His troubles also led to an Institute of Medicine report that faulted Duke's oversight and found broad problems in the cancer field with using gene signatures and other biomarkers to guide treatment.

Researchers now suspect that this finding will open up a whole new area of medical genetics, with DNA repair genes becoming the prime suspects in causing other cancers and hereditary illnesses.

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

Mutations in the gene predispose to colon cancer and cancer of the uterus, and increase the risk of developing some other, rare tumours.

Others are involved in conditions that tend to occur alongside ASD, such as psychiatric disorders and epilepsy, and interestingly, some of the genes are also involved in cancer.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected prcancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected prCancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected prcancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

BRCA1 and 2, genes whose proteins are supposed to work as tumor suppressors and also repair DNA damage, were the first known risk factor genes for familial breast cancer as well as ovarian and other cancers.

«Additional studies are needed to see if these nanoparticles could also effectively deliver other antitumor genes for the treatment of brain tumors as well as systemic cancers.»

Using Epiviz and Bioconductor, the research team found consistent regions of DNA methylation changes in colon cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer cancer types.

If the retroviruses infected a person during or after a transplant, they could disrupt important human genes, leading to cancer or other diseases.