Not exact matches
Important factors that could
cause actual results to differ materially from those reflected
in such forward - looking statements and that should be considered
in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability
of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost
of accommodating, announced increases
in the build rates
of certain aircraft; 6) the effect on aircraft demand and build rates
of changing customer preferences for business aircraft, including the effect
of global economic conditions on the business aircraft market and expanding conflicts or political unrest
in the Middle East or Asia; 7) customer cancellations or deferrals as a result
of global economic uncertainty or otherwise; 8) the effect
of economic conditions
in the industries and markets
in which we operate
in the U.S. and globally and any changes therein, including fluctuations
in foreign currency exchange rates; 9) the success and timely execution
of key milestones such as the receipt
of necessary regulatory approvals, including our ability to obtain
in a timely fashion any required regulatory or
other third party approvals for the consummation
of our announced acquisition
of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our
other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability
of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and
other customers, and the risk
of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production
of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts
of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak
of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or
other security attacks, information technology failures, or
other disruptions; 16) returns on pension plan assets and the impact
of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition
of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and
other aerostructures suppliers; 19) the effect
of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both
in the U.S. and abroad; 20) the effect
of changes
in tax law, such as the effect
of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations
of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect
of such changes; 21) any reduction
in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability
of raw materials and purchased components; 23) our ability to recruit and retain a critical mass
of highly - skilled employees and our relationships with the unions representing many
of our employees; 24) spending by the U.S. and
other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment
of interest on, and principal
of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness
of any interest rate hedging programs; 28) the effectiveness
of our internal control over financial reporting; 29) the outcome or impact
of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and
other cost savings; 32) our ability to consummate our announced acquisition
of Asco
in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and
other business disruptions for ourselves and Asco as a result
of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks
of doing business internationally, including fluctuations
in foreign current exchange rates, impositions
of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among
other things.
Other activities include: producing products that may be recycled at the end
of their lifespan for material reuse; reducing energy consumption
in operations; or even re-engineering distribution methods as a means
of reducing long - distance travel during product delivery, ultimately reducing fossil fuel consumption (and the
disease -
causing air pollution that is its byproduct).
(It should be noted that
other major
causes of deaths
in America include lung
disease, car accidents, and Alzheimer's.)
«We don't have a specific list
of conditions that would be disqualifying, but certainly uncontrolled medical problems (whether it's hypertension or heart
disease or lung
disease, or many
other conditions), would most likely
cause concern and result
in disqualification,» Dr. Tarah Castleberry, an assistant professor
of aerospace medicine at the University
of Texas Medical Branch
in Galveston, told Reuters Health by email.
Economists use the term «Dutch
disease» to describe the way resource booms spur an inflationary spiral that
causes other industries to wither and hampers overall competitiveness, as happened to the Netherlands as a result
of its natural gas boom
in the 1960s.
Scientists aren't sure what's
causing the spike
in cases
of the
disease, which has seen a resurgence
in Angola and
other parts
of Africa, along with Brazil.
The whole point
of Dutch
disease is that a productivity shock
in one exportable sector can
cause a decline
in every
other exportable sector.
VIX and all these
other things became a symptom,
of what I call now, a
disease of rising inflation and rising interest rates that then
caused this explosion
in volatility.
This is hypothesized to happen for many different reasons, including a decline
in the competitiveness
of other economic sectors (
caused by appreciation
of the real exchange rate as resource revenues enter an economy, a phenomenon known as Dutch
disease), volatility
of revenues from the natural resource sector due to exposure to global commodity market swings, government mismanagement
of resources, or weak, ineffectual, unstable or corrupt institutions (possibly due to the easily diverted actual or anticipated revenue stream from extractive activities).
Tocqueville employs this insight to describe the emotional detachment that comes from the modern, democratic erosion
of the social ties that have aristocratically or traditionally bound people to each
other: Individualism, Tocqueville explains, is the «heart
disease» that
causes apathetic, asocial immersion
in the present.
You have to wonder if the rising rate
of chronic
disease in the USA is
caused by GMOs or some
other thing the stinking government is covering up.
The depravity
of their cynicism astounds even a crusty old bird like me: If Golden Rice is a success and effectively reduces blindness,
disease, and death
caused by vitamin A deficiency
in millions
of rice consumers, it will pave the way for
other GM food crops that may be healthier for people and good for the environment.
A poor diet comprised
of red meat, fats and bad carbohydrates can allow pathogenic organisms to develop
in our systems
causing heartburn, acid reflux, colitis, irritable bowel syndrome and
other even more serious
diseases.
This can
cause malabsorption
of essential nutrients, anemia, infertility, stunted growth
in children, digestive problems, weight loss, osteoporosis, tooth damage, skin rashes, fatigue, vomiting, diarrhea, joint pain, migraines, depression, foggy mind, seizures, ADHD - like behavior, irritability, and
other behavioral changes, according to the Celiac
Disease Foundation.
This is important: high cholesterol can be an indicator
of other issues
in the body that can increase risk
of heart
disease, but cholesterol itself is not the
cause.
Force
causes concussions; Concussions are strongly correlated with degenerative brain
diseases like CTE; CTE and
other associated long - term neurological disasters are the chief reason youth participation
in football has been down or flat recently, and also the thing driving the current wave
of lawsuits and legal drama surrounding the NFL and
other leagues.
And second, because symptoms
of heart
disease can be more variable
in women, women may not realize that their symptoms are related to heart
disease and attribute them to some
other cause.
Though the
cause of colic is unknown, Lester has
in some cases identified gastroesophageal reflux
disease (GERD), pain, food allergies, and
other sensitivities.
One
of these, IgA, which is present
in highest amounts
in the first few days
of life, contains many antibodies against viruses, bacteria and
other disease -
causing organisms.
According to one study published
in the Archives
of Disease in Childhood found that among babies who had experienced prolonged crying at a very young age (either from colic or
other causes) had an average IQ at five years old that was nine points lower than the control group.
In fact, dental studies show that dry mouth (called xerostomia)
causes increased incidence
of gum
disease, cavities and
other oral health conditions which have been associated with premature birth.
Certainly some
of these are involved, as may be excessive processing
of foods, drug residues
in foods and water, now - common deficiencies
in DHA and vitamin D, excessive hygiene, lack
of challenging childhood
diseases, and likely
other nutritional and environmental
causes we have yet to learn
of.
The leading
cause of maternal mortality
in the US is cardiac
disease, followed by
other pre-existing conditions.
«Never ever
in a million years did we think our water was contaminated, or our water would
cause cancer or thyroid
disease or a host
of other diseases,» Baker said.
In other words: it's far from certain that Alzheimer's
of some
other disease causing dementia develops.
It's true that age is correlated with an increased risk
of Alzheimer's
disease and
other causes of dementia, but it's far from a certainty; it only develops
in about 5 to 8 per cent
of people.
In the early 1990s Lane and Humboldt State University ecologist Richard Brown began to suspect some of the spirochetes they saw in ticks were not causing classic Lyme disease but rather other related infections entirel
In the early 1990s Lane and Humboldt State University ecologist Richard Brown began to suspect some
of the spirochetes they saw
in ticks were not causing classic Lyme disease but rather other related infections entirel
in ticks were not
causing classic Lyme
disease but rather
other related infections entirely.
Through clinical follow up
of dogs genetically at risk, the research team was able to confirm that several disorders
cause the same
disease signs also
in other than previously described breeds.
Although the same phenomenon may occur with
other infectious
diseases, the study focused on TB — one
of the largest
causes of morbidity and mortality
in Zimbabwe, especially among people living with HIV.
In other words, the presence
of G. vaginalis made E. coli more likely to
cause severe kidney
disease.
Cigarette smoking is the leading
cause of preventable
disease and death
in the United States, with more people dying from nicotine addiction than any
other preventable
cause of death.
In these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to functio
In these and
other inherited
diseases, 10 to 15 percent
of the single - base pair mutations that
cause the
disease create a misplaced, premature «stop» codon
in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to functio
in the middle
of the gene —
causing the machinery
of the cell to prematurely halt synthesis
of the protein, which destroys its ability to function.
It was previously shown by
others that a rare
disease called generalized pustular psoriasis (
in which the skin erupts into pustules) was
caused by a genetic mutation that resulted
in unrestrained activity
of a protein normally produced
in our skin, called IL - 36.
The researchers tested OCA
in three groups
of patients: 10 with primary BAD, where the intestine is otherwise healthy; 10 with secondary BAD, where malabsorption can occur as a result
of another
disease such as Crohn's; and eight with
other causes of chronic diarrhea, who served as a control group.
Ames is more likely than
other strains
of anthrax to
cause disease in animals immunised with the standard US anthrax vaccine, which is now being given to US troops.
James Lupski, a medical geneticist at Baylor College
of Medicine
in Houston, Texas, says that when his team identifies a potentially
disease -
causing mutation
in a patient genome, he e-mails
other scientists to see whether they have found similar mutations.
A new strategy — an injectable antibody — for lowering blood lipids and thereby potentially preventing coronary artery
disease and
other conditions
caused by the build - up
of fats, cholesterol, and
other substances on the artery walls, is supported by findings from two new studies from researchers
in the Perelman School
of Medicine at the University
of Pennsylvania.
In 2013 Obama directed the U.S. Centers for
Disease Control and Prevention (CDC) and
other federal agencies to study the
causes and prevention
of gun violence.
Coeliac
disease is
caused by an abnormal reaction to gliadin, a gluten protein found
in wheat (and similar proteins
of the tribe Triticeae which includes
other cultivars such as barley and rye).
Other causes of heart failure include systemic processes such as inflammatory
diseases, metabolic disorders, endocrine derangements, and kidney
disease, which result
in an unknown number
of cases.
It may also reduce the effects
of changes
in fat that
cause insulin resistance and
other symptoms
of metabolic
diseases, such as diabetes,» Dr. Kahn says.
Neurodegenerative
diseases are
caused by the death
of neurons and
other cells
in the brain, with different
diseases affecting different regions
of the brain.
This week
in Science we profile Yale School
of Medicine neuropathologist Laura Manuelidis, who has spent her career fighting the consensus that misfolded proteins called prions
cause «mad cow
disease» and
other related brain
diseases.
We intend to follow up this work by trying to get yet more detail on the prevalence
of such mutations as well as by testing for these events
in other tissues; most genetic investigations are performed only
in blood, so we may have missed some
disease -
causing mutations by not testing elsewhere,» Dr Gilissen will conclude.
There are four types
of blast trauma injury: 1) primary injury
caused directly by the pressure wave, which can travel through tissue at velocities close to that
of sound
in water, 2) secondary injury
caused by objects put
in motion by the blast, 3) tertiary injury
caused by an individual thrown into motion by the blast and hitting surrounding objects, and 4) quaternary injury
caused by burns, explosion - related injuries, illnesses and
diseases not attributed to the
other three blast trauma types.
The more Duesberg looked for answers, the more he came to believe that the original hypothesis
of top AIDS researchers was actually correct: The
disease was — at least
in the United States — brought on by drug use and
other immune - suppressing
causes.
«With cancer now surpassing heart
disease as the leading
cause of death
in California and 22
other states, we need to increase cancer screening efforts to save lives,» he said.
The researchers also say that their data - scouring methodology may be used to help identify previously unknown genetic
causes of other diseases, even
in cases where data has already been exhaustively analyzed.
Although the cholera bacterium, Vibrio cholerae, is usually thought
of as a
disease -
causing organism, most strains never infect people and live freely
in estuaries and
other brackish waters.
Overall, nearly 20 percent
of the men and 12 percent
of the women who participated
in the study developed or died from heart
disease, a suite
of conditions that includes stroke, coronary heart
disease caused by the buildup
of plaque
in the heart's arteries, acute coronary syndromes such as heart attack, and
other diseases.