When activated, these cells multiply and then transform into
other cell types required to replace worn out cells under conditions of normal tissue maintenance.
Not exact matches
Embryos» self - healing DNA came as a surprise, because gene editing in
other types of
cells usually
requires an external template, Mitalipov says.
The stem
cells produced through this therapeutic cloning would, like
other embryonic stem
cells, be capable of developing into many
cell types and serve as a repair system for whatever part of the body
required replenishment at the time.
Next, the researchers would like to investigate how to culture the
other types of progenitor
cells that are
required for a full kidney, in addition to the nephrons formed by NPCs.
Other research in this area has
required that
cells of one
type first be returned to a more generally undifferentiated stem
cell state, which can introduce fresh problems.
The results show that generation of an optimal immune response to cancer
requires cooperation between two
types of memory T
cell — one circulating in the blood and the
other resident in tissues — that can be reactivated with current immunotherapy strategies.
The authors note that the formation of each different organ bud
type may
require some fine tuning to optimize tissue self - organization, and further addition of neural
cell types may be necessary, but this research may soon provide exciting model systems for the study of basic biology and pathology as well as providing appropriate replacement tissues for the treatment of many patients with no
other viable options.
Compared with alternative protocols for biliary differentiation of hPSCs, our system does not
require coculture with
other cell types and relies on chemically defined conditions up to and including the generation of CPs.