Sentences with phrase «other cell types such»

Moreover it remains unclear how β - cells can generate a graded response to insulin or even remain sensitive to it, conceivably being exposed to far greater concentrations of the hormone than other cell types such as adipocytes or muscle cells.

Not exact matches

However, there may be other conditions that cause an exaggeration of this type of jaundice, such as a more rapid than normal breakdown of red blood cells.

However, there may be other conditions which cause an exaggeration of this type of jaundice, such as a more rapid than normal breakdown of red blood cells.

Other adult stems cells exist — such as hematopoietic stem cells, which can generate all types of blood cell and mesenchymal stem cells, which can turn into bone, fat and cartilage cells.

Action potentials can be created by many types of cells, but are used most extensively by the nervous system for communication between neurons and to transmit information from neurons to other body tissues such as muscles and glands.

«We'd like to extend this further to examine for driver genes in other types of lung cancer, such as squamous cell lung cancer.»

The study published in Cancer Cell shows that exosomes from tumor cells of breast cancer (and other tumor types such as ovarian and endometrial) are different in size and composition than those of healthy cells.

The team believes that whichever way BMP - 7 is used, it will be less risky than other treatments for type 1 diabetes that are currently being investigated, such as those that create pancreatic cells from stem cells, or by introducing new genes into the body.

«But mounting evidence confirming angiotropism and EVMM has revolutionized the knowledge of how cancer spreads through the body to the point that other scientists have confirmed the process in other solid tumor cell types such as pancreatic cancer.»

To extend their initial findings, the researchers seek to understand the signals that coax these cells to develop, and whether they play roles in other autoimmune diseases, such as lupus, multiple sclerosis, and type 1 diabetes.

Once lymphocytes find such invaders within the lymph node, they destroy them in collaboration with other types of immune cells.

Aging is a key risk factor for sAML because, over time, hematopoietic stem cells (which give rise to all other blood cell types) accumulate DNA mutations and changes in other molecules that put DNA instructions into action, such as RNA and proteins.

«Our main challenge was to find the right timing and concentration of the signaling molecules that would yield V2a interneurons instead of other neuronal cell types, such as motor neurons,» said first author Jessica Butts, a graduate student in the McDevitt lab.

Researchers from Hiroki Taniguchi's lab at the Max Planck Florida Institute for Neuroscience (MPFI) published a study in eNeuro in May 2017 showing for the first time that a unique type of inhibitory interneuron called chandelier cells — which are implicated in several diseases affecting the brain such as schizophrenia and epilepsy — seem to develop their connections differently than other types of neurons.

Marcus stresses that SaGA can be applied to additional cell types or environments, or other types of cancer cell behavior such as drug resistance.

Though this information - maximizing theory has been tested in a few types of behavior, Sharpee and others believe it could provide a basis for a larger, unified framework for understanding different types of behavior across species, cells, neurons and even larger scale phenomenon, such as resource allocation.

WHEN DISCUSSING neurotransmitters, most people think of the classical neurotransmitters, such as dopamine and serotonin — the primary chemical messengers used by neurons to communicate with one another and with other types of cells.

This approach is also being used to reverse engineer even more complex gut environments by integrating other cell types, such as immune cells, neuronal cells, and commensal microbes into the device.

One potential treatment involves injecting the wound with stem cells, which can change into other cell types, such as skin cells like keratinocytes, to help with the healing process.

It is believed to result from a combination of genetics and environmental factors such as irritants and allergens that drive T lymphocytes to produce factors that cause abnormal changes in keratinocytes, the predominant cell type in the outermost layer of skin, as well as changes in other cells in the underlying dermis.

It's uncertain whether other cell types, such as the immune cells that enter the lungs after an attack, have adenosine receptors — and scientists don't even know the source of the adenosine.

Future treatment of OS patients with this type of antibody could reduce amputations among young patients and future studies will clarify if such a treatment strategy will also block lethal spreading of the OS cells to other organs.

hESC researchers George Daley of Children's Hospital Boston and Sean Morrison of the University of Michigan told the panel why research on other types of stem cells, such as adult stem cells and so - called induced pluripotent stem cells (iPSCs), can't substitute for work on embryonic cells.

But many in the field will be waiting for the next steps: testing whether the resulting mouse pups are genetically normal, trying out the technique in other animals, and using other and less controversial types of cells — such as stem cells that can be extracted and cryopreserved from adult testicular tissue — as the starting point.

Although unequal division occurs among stem cells — allowing one daughter cell to remain a stem cell while the other matures into another cell type, such as a skin or muscle cell — the goal of a normal symmetric cell division is to generate identical daughter cells and increase cell number.

The ability of scientists to convert human skin cells into other cell types, such as neurons, has the potential to enhance understanding of disease and lead to finding new ways to heal damaged tissues and organs, a field called regenerative medicine.

«We think that its partner in this case, mGluR5, may also play a role of previously unrecognized breadth, acting within many different types of cells to intensify signals, such as those transmitted by GABA, glutamate, or other neurotransmitters,» Kim adds.

The mechanism used by Notch to regulate Myc in B cells is distinct from the mechanism used in other cell types, such as T cells, where Notch also regulates Myc.

In further studies, they plan to explore the role of autophagy in immune reactions toward other tumor cell types, to determine whether such therapies might be effective in a broad range of cancers.

Jacks» lab is now investigating the roles of genes associated with other types of lung cancer, such as small cell lung cancer.

Some cancer types, even when cancerous cells have traveled to other areas of the body, such as testicular seminoma and leukaemias and lymphomas in children, can have high cure rates if appropriate treatment is provided.

«We also discovered that this type of regulation is, interestingly, specific to beta cells, and not seen in other metabolic cell types such as liver and fat cells,» he says.

In addition, the molecular beacons technique http://www.lependart.com could have broad applications across regenerative medicine, because it could be used with other types of cells produced from stem cell cultures, such as brain cells or insulin - producing islet cells.

Depending on characteristics such as how many tumor cells, blood vessel cells, and immune cells are touching each other, the tumor microenvironment can nearly triple the chance that a common type of breast cancer (estrogen - receptor positive / HER2 negative) that has reached the lymph nodes will also metastasize, Condeelis and colleagues showed in a 2014 study of 3,760 patients.

We need a new type of vaccine that uses select components of a microbe or tumor cell or other cause of disease, and administers these with other defined substances, such as adjuvants, that directly exploit immunology.»

The things that we have demonstrated — such as the fact that the vertical nanowires can deliver any biological effector to any cell type in a spatially selected fashion — have drawn interest from many different people, and we have been working with stem cell institutes and others to demonstrate the unique utility of this particular platform.

«Pluripotent» stem cells can become any other type of cell, and they can be derived from embryos or created from adult cells such as skin cells.

Our Intestine - Chip also allows researchers to culture intestinal epithelial cells alongside other cell types, such as immune cells, and analyze how these different cell types interact.

To avoid such perturbations, researchers have developed a computer program that can distinguish between cell types and identify subcellular structures, among other features — all without the fluorescent probes our human eyes rely on.

Once implanted, the cells are designed to differentiate into the various cell types that make up the pancreatic islet, which could allow for production of insulin and other hormones, such as glucagon, needed to control blood sugar levels.

Such «induced pluripotent stem cells,» like other stem cells, are able to transform themselves into any type of cell in the body — making them ideal biological clay for tissue engineers to sculpt.

We invite original innovative research on the rational engineering of plant systems at all levels, including proteins, protein complexes, sensors, metabolic and signalling pathways, microcompartments such as carboxysomes, subcellular compartments, cell types or tissues, as well as the engineering of novel plant hybrid species and the interactions of plants with viruses, bacteria, and other organisms.

Goulding's lab studies the immediate and downstream effects of neuronal cell loss, such as ongoing changes to spared neurons or to other cell types that make up the circuit, and determines how they adapt to the loss of a particular neuronal cell type.

Moreover, there are yet other cell types — such as visceral adipose tissue macrophages and cytotoxic CD8 + T - cells — in which the age - related supernumerary accumulation of dysfunctional and apoptosis - resistant cells appears to play a highly deleterious role on tissue function, but where the cells are not «senescent» cells in the classical sense of p16Ink4a expression and the senescence - associated secretory profile observed in senescent fibroblasts.

The study relates to a particular type of vaccine (killed) against a particular virus, influenza, though the findings might hold true for other killed vaccines and for those vaccines consisting only of proteins produced by GM in bacteria, yeast or insect cells, against diseases such as hepatitis B (HBV) and human papilloma virus (HPV, the causative agent of cervical cancer).

These and other differences between hGDAsBMP and undifferentiated hGPCs and hGDAsCNTF, such as the marked differences in expression of axon growth inhibitory CSPGs and the expression of GDNF, may all contribute to creating a particularly effective cell type for promoting functional recovery in the traumatically injured adult central nervous system.

Efforts to produce other cell types, such as liver cells, have proved far more difficult, he says.

In addition to CAR - T cell therapy, we focus on other types of immunotherapy research, such as vaccine therapy and checkpoint inhibitors.

Recently, some other cytokines (such as tumor necrosis factor) or chemical drugs were also found to up - regulate several IFN - inducible gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.

«Our approach could lead to a simpler method of creating iPSCs or could be used to directly reprogram skin cells into other cell types, such as heart cells or brain cells.»