Sentences with phrase «other cellular genes»

Not exact matches

A host of other genes, which control many other cellular processes do not show such abnormal DNA methylation after smoke exposure.

Gene activity can't be efficiently measured directly, but can be inferred by monitoring RNA, the molecules that carry information from the genes for producing proteins and other cellular activities.

Yamanaka's group and two others followed up earlier this year with firmer evidence that these induced pluripotent stem (iPS) cells faithfully mimicked the patterns of gene activity and cellular differentiation observed in embryonic stem cells.

At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment.

(The markers include genes and other DNA components, such as parts of the DNA that turn proteins on or off, and cellular components that play a role in regulating genes.)

Once the gene was in place, the normal cellular machinery produced it just like any other enzyme.

Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.

The NIH Common Fund's Library of Integrated Network - based Cellular Signatures (LINCS) program aims to create a network - based understanding of biology by cataloging changes in gene expression and other cellular processes that occur when cells are exposed to a variety of perturbing agents.

They found that the transplanted cells strongly activate genes that help to guard against damage from ER stress, and suppress other genes that may trigger cellular attempts to self - destruct.

She also founded the Kathryn W. Davis RNAi Research Center at Cold Spring Harbor to support the understanding of how this cellular machinery might be programmed to turn off genes that lead to cancer and other disorders.

Basically what was happening when you use a hematopoietic stem cell to correct an inherited metabolic disease is that through engraftment of that cell you are allowing that cell to become the replacement source for the missing enzyme or other factor - almost like a cellular form of gene therapy or, as I call it, «poor man's gene therapy».

Others were unanticipated, including significant differences in expression levels among genes involved in fundamental cellular processes such as ribosomal biogenesis, transfer RNA processing, and Notch - signaling — part of a complex system of communication that governs basic cellular activities and coordinates cell actions.

He has made several important contributions in this area including identifying a new strain of CHIKV virus, identification of host cellular targets of HIV accessory genes, new novel DNA vaccine approaches for HIV, CHIKV, RSV, Dengue, MERS and Zika among others.

In eukaryotes, a homeobox encodes a protein domain (the homeodomain) which can bind DNA that act as part of transcription factors to switch on cascades of other genes that induce cellular differentiation by initiating the cascades of coregulated genes required to make individual tissues, organs, or body parts.

On the other hand, using near - term nanotechnology to deliver into cancer cells siRNA or miRNA to alter cellular gene expression might also make it possible to «repair cancerous cells».

In certain cancers, low - complexity domains are improperly attached to other proteins that may then incorrectly form droplets in cellular locations, leading to mis - regulated expression of genes, Fawzi said.

The focus of the conference was connecting how epigenetics (cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence — in other words nutrition and lifestyle choices) impact whether or not an individual actually develops a specific health issue even though they have a SNP mutation.

Fasting, among other things, activates SIRT genes (a great cellular tune - up) and have recently been shown to trigger stem cell regeneration of the immune system.

Molecular medicine and molecular biochemistry provide the what and how these changes, especially deleterious ones may be treated, cured, suppressed, or understood in context with other gene regulatory mechanisms and transcription and translation coupled systems within the actual cellular environment.

Additional upregulated signal transduction related genes encoded proteins polycystin - 1L1, MLP and LIM regulatory proteins, fibrillins or related proteins containing Ca2 + - binding EGF - like domains, Ca2 + / Mg2 + - permeable cation channel, and other differentially expressed putative transcripts that may play a role in cellular signaling, including known extracellular proteins c - type lectin and collagen (see electronic supplementary material, table S5).

He has significant experience with respect to transactions related to small molecule pharmaceuticals, biologics, cellular therapies, gene therapy, diagnostics and medical devices, both within the United States as well as in other major markets such as Europe, Asia and South America.