Sentences with phrase «other cellular proteins»

However, in the new study, when the researchers looked at Sup35 surrounded by other cellular proteins, they found that the intrinsically disordered region actually does take on a regular structure, which they believe to be beta sheets.

The research team has also investigated the interaction of ADAR proteins with other cellular proteins.

However, FUS and other proteins in its RNA - binding class seem to operate differently from many other cellular proteins.

Bex acts on a «master regulator» protein called retinoid X receptor (RXR), which controls a network of other cellular proteins.

The same basic principle could also apply to other cellular proteins.»

In the new study, expanding upon what scientists previously understood about intrinsic immunity, the researchers found that cells can subsequently respond to latent HCMV by employing other cellular proteins called lysine demethylases to reactivate the virus.

Not exact matches

Like fellow Bay area start - up Geltor, Perfect Day is one of a new breed of companies in the «cellular agriculture» business — using genetically engineered yeasts that have been «programmed» to produce proteins or other ingredients found in plants or animals - on an industrial scale, without raising animals, and with less impact on the environment.

Some proteins associate with other proteins, either to regulate them or to form larger cellular machines.

RNA, widely known as a cellular messenger that makes proteins and carries out DNA's instructions to other parts of the cell, is now understood to perform sophisticated chemical reactions and is believed to perform an extraordinary number of other functions, at least some of which are unknown.

Autophagy is also used for self - cleaning to eliminate other proteins as well as damaged or unneeded cellular components.

What's more, only a very small percentage (6 %) of proteins encoded by Pandoravirus salinus are similar to those already identified in other viruses or cellular organisms.

Protein aggregates and other cellular waste are delivered to lysosomes, the digestive apparatus in cells, and degraded.

Gene activity can't be efficiently measured directly, but can be inferred by monitoring RNA, the molecules that carry information from the genes for producing proteins and other cellular activities.

The research team has been using NMR — a technique related to the one used in MRI body scanners and capable of visualising molecules at the smallest scales — to examine how small components of herpes virus help it to multiply by binding themselves with other large molecules; this produced images of a monkey herpes virus protein interacting with mouse cellular protein and viral RNA.

Dr. Jan Höpker, Dr. Silke Oeljeklaus, Prof. Dr. Nikolaus Pfanner, Dr. Sebastian Stiller, Prof. Dr. Bettina Warscheid, Prof. Dr. Nils Wiedemann and their team of researchers have demonstrated that this protein complex is essential for the integration of certain proteins into the inner membrane of mitochondria — proteins that play a role in cellular respiration and other processes.

Autophagy is a cellular cleaning mechanism that normally clears any protein aggregates or other «trash» within the cells, but that is somewhat disturbed in Alzheimer's patients.

They follow individual proteins in clusters of stem cells, trace cellular migration in a developing fruit fly larva, and observe muscle contractions in a nematode embryo (see video, above), among other tasks.

This latter capability is extremely valuable to biomedical research, which relies heavily on fluorescent probes to label and track proteins, nucleic acids, and other cellular components.

At the cellular level, the clock is controlled by a complex network of genes and proteins that switch each other on and off based on cues from their environment.

(The markers include genes and other DNA components, such as parts of the DNA that turn proteins on or off, and cellular components that play a role in regulating genes.)

Crucially, the process largely maintains the relative orientation and interconnection of proteins and keeps other cellular structures intact: it distorts the relative position of proteins by 1 — 4 %, Boyden's team calculated.

The gel form of FUS allows it to collect other cellular components that are necessary to make new proteins, and delivers them in a compact, concentrated form to the outer edges of the neurons.

The bug manufactures an amino acid not made by any other living thing and uses it to construct its proteins, the molecules that carry out the lion's share of cellular chemistry.

Other proteins involved in cellular transport and protein synthesis were also identified.

Biochemistry is the study of the structure and function of cellular components, such as proteins, carbohydrates, lipids, nucleic acids, and other biomolecules.

Loss of hearing is linked to a decrease in a critical cellular protein, and elevating the activity of this protein could prevent noise - induced hearing loss, as well as potentially benefiting a host of other aging - related conditions

Other BrightFocus - funded research is studying drugs that stimulate the removal of misfolded protein that is in other cellular garbage, from the retinal pigment epithelium in the sublayer of the retina that we were talking aOther BrightFocus - funded research is studying drugs that stimulate the removal of misfolded protein that is in other cellular garbage, from the retinal pigment epithelium in the sublayer of the retina that we were talking aother cellular garbage, from the retinal pigment epithelium in the sublayer of the retina that we were talking about.

Details that can be included are biochemical reactions; gene regulatory networks; genetic interactions; proteins, small molecules, DNA, RNA, complexes and their cellular locations; complex assembly and transport; post-translational protein modifications; citations; experimental evidence; and links to other databases e.g. protein sequence annotation.

For example, cellular reprogramming is an inefficient process because many of the target areas on the genome are covered by other proteins, like a childproof cap on a medicine bottle, which prevents the reprogramming factors from binding there.

Moderna's mRNA Therapeutics ™ platform builds on the discovery that modified mRNA can direct the body's cellular machinery to produce nearly any protein of interest, from native proteins to antibodies and other entirely novel protein constructs with therapeutic activity inside and outside of cells.

LKB1, originally identified as a tumor suppressor protein, is currently thought as a critical regulator of cellular metabolism and growth by controlling the activity of AMP - activated protein kinase (AMPK) and also 12 other kinases that are closely related to AMPK.

Their activity increases in response to heat, toxins, and various other forms of cellular stress, and dialing up the activity of heat shock proteins is involved in a number of methods demonstrated to slow aging in laboratory animals.

Activated ERK1 / 2 modulates the functions of several transcription factors, protein kinases, protein phosphatases, cytoskeletal proteins, signaling molecules, apoptosis - related proteins, as well as other types of proteins [32], while activated AKT modulates the function of numerous substrates involved in the regulation of cell survival, cell cycle progression and cellular growth [33, 34], whereas JNK acts as pro-apoptotic as well as anti-apoptotic depending on the conditions [35].

Finally, in a collaboration with Frank Jülicher's group at the Max Planck Institute for the Physics of Complex Systems, we are using these data to develop physical models that will help us understand how local cellular adhesive, elastic and contractile properties are influenced by PCP proteins and other molecules, and how they combine to produce specific packing geometries at a global level.

The investigators found that the communication between two proteins in cellular post office is responsible for the detachment and movement of cancerous cells from lungs to other regions of the body.

These diseases are thought to be caused by prions (pronounced pree - ons), infectious protein particles — normal cellular proteins that supposedly change their shape and then mold other protein molecules into the same sickly altered form.

In eukaryotes, a homeobox encodes a protein domain (the homeodomain) which can bind DNA that act as part of transcription factors to switch on cascades of other genes that induce cellular differentiation by initiating the cascades of coregulated genes required to make individual tissues, organs, or body parts.

His research interests include cellular lipid and protein degradation systems — and their malfunction — in relation to Parkinson's disease and other synucleinopathies.

Analysis of cellular localization of known actin cross-linking proteins in mouse melanoma B16F1 cells revealed that fascin was specifically localized along the entire length of all filopodia, whereas other actin cross-linkers were not.

While reproductive proteins with conserved homologs in different phyla are not uncommon, most of them are involved in general cellular functions, and are hence also required for other non-reproductive processes [18], [19].

For example we can visualize fluorescently labeled proteins and compare the quantity and localization relative to other labeled cellular components.

Other flow cytometry applications include: cellular phenotyping by multiparameter cytofluorimetric analysis, sorting of fluorescence protein - tagged cells, assessing apoptosis and cell cycle status, the identification / isolation of stem and cancer stem cells (e.g., marker positive, side - population, etc.) and the deposition of single cells.

In certain cancers, low - complexity domains are improperly attached to other proteins that may then incorrectly form droplets in cellular locations, leading to mis - regulated expression of genes, Fawzi said.

In humans and most other eukaryotes, the RNAi pathway can reduce cellular protein production by reducing the proteins» RNA templates.

The prize was for his work on autophagy, a kind of cellular housekeeping that helps clear the cell of damaged proteins and other potentially toxic debris.

Certain particle compounds may directly generate ROS in vivo because of their surface chemistry (eg, metals, organic compounds, and semiquinones) or after bioactivation by cytochrome P450 systems (eg, polycyclic aromatic hydrocarbon conversion to quinones).6, 290 a, 290 b A particle surface or anions present on otherwise more inert particles may disrupt iron homeostasis in the lung and thereby also generate ROS via Fenton reactions.291 Other PM constituents may do so indirectly by the upregulation of endogenous cellular sources (eg, nicotinamide adenine dinucleotide phosphate [NADPH]-RRB- oxidase) 292,293 or by perturbing organelle function (eg, mitochondria) by taken - up PM components.261 Particle stimulation of irritant and afferent ANS fibers may also play a role in local and systemic oxidative stress formation.294 Given the rich antioxidant defenses in the lung fluid, secondarily generated oxidization products of endogenous molecules (eg, oxidized phospholipids, proteins) or a reduction in endogenous antioxidants per se may be responsible at least in part for the state of oxidative stress in the lungs (along with instigating the subsequent cellular responses) rather than ROS derived directly from PM and its constituents.

Subsequently, he made other critical links between the ubiquitin protein degradation system and proteins known to play central roles in vital cellular processes.

After all, when you eat protein, it gets broken down into protein building blocks called amino acids, and the amino acids are used for everything from cellular repair of all your damaged muscle fibers to a host of other metabolic reactions (19).

Stress resistance has not been assessed however and so the biological relevance of this finding is currently unknown.32 Several IER trials (75 - 85 % ER on restricted days) in overweight / obese populations have reported reductions in various markers of oxidative stress 37, 41, which in one study was accompanied by a complementary increase in the anti-oxidant uric acid.37 In a direct comparison of IER (75 % ER for two days / week) and CER, both ER strategies displayed equal efficacy in reducing levels of fast - acting advanced oxidation protein products (AOPP) after six months, which displayed a tendency to occur earlier (i.e. at three months) in the IER group.41 Levels of slow - acting (i.e. long term) AOPP tended to decrease in the IER group and increase in the CER group which the authors proposed may have resulted from IER - induced activation of autophagy, a key homeostatic cellular process in which dysfunctional or unnecessary cellular proteins are degraded and recycled.41 On the other hand, a follow - up study using similar IER / CER protocols demonstrated comparable reductions in AOPP in both groups after three months.48 Summary and Future Research Directions

As an adult, it does lots of other things, including increased bone mineralization and muscle mass, protein synthesis, cellular growth, and fat breakdown.