«Now that we have the gene, we can actually use that gene sequence to temporarily silence the gene and make rye and
other chromosomes pair with wheat and transfer genes by a natural method into wheat without calling it GMO,» Gill said.
Not exact matches
During that process,
chromosomes pairs get drawn apart and duplicated, but only one of the four resulting
chromosomes will make it into the egg cell; the
others are destroyed.
During reproduction,
chromosome pairs normally swap genes and cancel out each
other's mutations.
Published in Nature Communications, the study shows that as egg cells mature in older women,
paired copies of matching
chromosomes often separate from each
other at the wrong time, leading to early division of
chromosomes and their incorrect segregation into mature egg cells.
Defective genes can be caused by mutations in either the maternally - inherited mitochondrial genome (mtDNA) or more frequently, the genes located on the autosomes, the 23
pairs of
chromosomes which are responsible for all traits and all
other genetic diseases.
Several
other technical advances helped, including the development of huge yeast artificial
chromosomes, so - called «megaYACs», which can store up to 1.4 million
pairs of DNA in one big chunk — 35 times more than can be stored in bacteria, the conventional way to clone DNA.
Because a trisomic cell contains two copies of a
chromosome from one parent and one copy of that
chromosome from the
other parent, one in three embryos which revert from trisomy to disomy will end up with a
pair of
chromosomes from just one parent.
During meiosis, homologous
chromosomes, one from the mother and the
other one from the father,
pair with each
other and exchange parts (recombine).
This requires that homologous
chromosomes find each
other and
pair, and that each
pair of homologs become physically linked via at least one crossover before cells enter the first meiotic metaphase.
Trisomies can occur with
other pairs of
chromosomes as well, giving rise to different disorders, but Down's is defined as the one affecting the 21st
pair only.
The
chromosome pairing drives a host of
other differences between the male and female Lab, including size and a few personality traits.