In zebrafish, injection of low doses of both Tuba and Cdc42 antisense morpholinos, which had no effect when administered separately, led to severe phenotypes similar to those seen following knockdown of
other ciliary proteins.
Not exact matches
Lipschutz and
others previously showed that the exocyst, a protein targeting complex, plays a crucial role in receiving these «zip - coded packages» containing
ciliary proteins.
Other problems identified less frequently included eyelid tumors,
ciliary body cysts, and retinal dysplasia.
Primary
Ciliary Dyskinesia (PCD) is an inherited disorder characterized by recurrent infections of the upper and lower respiratory tract, reduced fertility in males and situs inversus, a transposition of internal organs resulting in a mirror image of the normal placement of the heart and lungs and sometimes
other organs, in about 50 % of affected individuals (Kartagener syndrome).
Introduction: Primary
ciliary dyskinesia (PCD), previously called immotile cilia syndrome (ICS), is a divers group of inherited structural and functional abnormalities affecting the cilia of the respiratory tract mucosa and
other organs which results mainly in recurrent respiratory tract infections.