Like other complex diseases, it is likely that this heterogeneity has hampered the ability of investigators to identify genetic variants associated with the disease.
We have also made contributions to the study
of other complex diseases, including breast cancer, melanoma, oral clefts, eye disorders, Chiari malformation, ADHD and autism.
It also sought to match epigenetic changes and genetic differences to the physical characteristics of each cell type and use this knowledge to understand how these can lead to blood disorders, cancer and
other complex diseases.
The findings highlight the importance of combining information on DNA changes, genes, and gene expression in future studies of these and
other complex diseases, Dr Satsangi and colleagues believe.
So far, «genome - wide association studies» have identified variant DNA sequences showing statistical association with these and
other complex diseases, but demonstrating a mechanistic role for these variants has proven elusive.
The community has extremely high rates of hypertension, diabetes, asthma and
other complex diseases.
For custom gene expression projects the Genomics Core has a platform that uses sets of human and mouse custom arrays whose probe content is aimed at gene expression studies in the areas of cancer, immunology and
other complex diseases.
Many other types of cancers also remain biological mysteries, and Capecchi expects that each may require its own animal model, as will
other complex diseases and neurodegenerative and neuropsychiatric disorders.
Unfortunately, the acute - care approach to medicine is ill - equipped to address chronic pain and
other complex diseases.