Sentences with phrase «other disease models»

They also plan on testing if other disease models, such as lupus, are driven by the same mechanisms.

«We use zebrafish to study Alagille syndrome because these vertebrates allow us to use experimental approaches that aren't possible with other disease models,» says Duc Dong, Ph.D., assistant professor in the Human Genetics Program at SBP and senior author of the paper.

Within one year a major supplier was offering two different rat models of schizophrenia, two of Alzheimer's, and six of Parkinson's disease — in addition to cancer and other disease models.

«These results enable future studies in Alzheimer's and other disease models and highlight the importance of basic research which precedes drug - discovery,» says Jaan - Olle Andressoo.

Not exact matches

WeFarm models can predict disease, ripening periods, shortages, drought, soil conditions, farm characteristics and many other vital supply chain issues.

Maine statute directed the committee to develop this model policy based on the current research and best practice guidelines from the national Centers for Disease Control and Prevention and other states» concussion management documents.

Of note, our models may underestimate the true maternal costs of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and MI.

Creating and maintaining a healthy lifestyle that you stick to beyond the birth will also make you a model of healthy living for your child, helping him / her to avoid obesity, diabetes, heart disease and other conditions for a lifetime.

The behavioral tests used here modeled one dimension of the disease — an inability to experience pleasure from normal activities — but not others, such as stress and anxiety, and probably tap into different brain mechanisms in mice than in humans, he says.

«What we had done for the cystic fibrosis pigs was applicable to other diseases» for which the previous animal models were not sufficient, Rogers says.

The researchers are beginning to use their model to test whether Zika virus, and other pathogens associated with congenital disease, can infect placental cells and / or cross the placental barrier.

«Gene - delivery system prevents vision loss from inherited eye disease: Initial testing in animal models holds promise for treating Leber congenital amauroisis and other congenital visual disorders.»

Reductions in biodiversity from illegal wildlife trade can have other substantial negative human health impacts, including the loss of potential sources of pharmaceuticals, experimental models for studying disease, crop pollination and micronutrients for humans lacking alternative sources of protein.

They also note that Aedes mosquitoes also spread dengue and chikungunya, two other notorious tropical diseases, so the model effectively measures risks of all three diseases rather than any one of them alone.

«We are fortunate to have each other's expertise in mathematical modeling and infectious diseases,» Wan said.

Others on the team include a veterinary epidemiologist and an economist from Kansas State University, and a disease spread model designer.

It could also provide a model approach against other insect - borne diseases.

Another problem is that modeling studies, like this one, are inherently less powerful than other kinds of medical research: randomized clinical trials, the gold standard in medical research, in which patients are randomly assigned different treatments or no treatment; case - control studies, which compare patients who have a condition with those who do not; or cohort studies, which determine the risk of contracting a disease by studying a group of people with similar demographics.

She kept feeding the new data into mathematical models that factored in the animals» age, migration patterns and disease prevalence in the population, among other things.

Still, he says, other groups have arrived at opposing results regarding the role of T cells in the disease, in part, perhaps, because their animal models aren't the same.

If I had gone that other route, I would most likely be studying basic mechanisms of immunity rather than applying them to the study of infectious and autoimmune disease models.

These observations and others have convinced the researchers that their CRISPR / Cas9 and hPSC system produces a stable, biologically accurate human model for a common genetic disease where new understanding and new therapies are desperately needed.

More work is needed to determine whether the findings on rapamycin hold true in animal models of Leigh syndrome and other neurodegenerative diseases, and to ascertain how exactly rapamycin is altering the metabolism of the cells.

The human cell - based disease model is expected to lead to a better understanding of these disorders and other illnesses, Hsiao said.

«This computational model might be used to predict other life - threatening episodes of diseases,» Chen said.

Like humans, songbirds such as zebra finches (above) can learn vocalizations, and this similarity suggests they could serve as models for research on Huntington's disease and other neurodegenerative disorders that affect speech and vocalization.

Researchers at RTI International will continue to further refine their model to incorporate other national health issues, such as obesity, and to also assess how positive interventions could alter the course of kidney disease in America.

the National Institutes of Health being the biggest funder but in the case of the flu, the Centers for Disease Control also fund their own research and a little bit about that research, and other countries also have their own ways of funding things, typically government, and the researchers in their current model of working, they are not required to release their scientific data until they publish it.

Using experimental models and state - of - the - art technology, the scientists found that switching off this protein leads to better control of glucose production from the liver, revealing a potential new target that may be used to treat type 2 diabetes and other metabolic diseases.

«The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate elimination of HIV - 1 DNA in latently infected T cells and other sanctuary sites for HIV - 1, including brain cells,» Dr. Khalili said.

Using a pig model may help other scientists more effectively test treatments for colon cancer, type 2 diabetes and other chronic diseases.

«Additionally, the genetically - engineered mouse model will allow us to test potential treatments aimed at correcting achlorhydria, not just for gastric NETS, but also for other diseases of the gastrointestinal system such as Barrett's esophagus (chronic inflammation of the lower part of the esophagus), or hiatus hernia,» says Dr Calvete.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

Muotri noted that the research represents one of the first efforts to use iPSCs and brain in - a-dish technology to generate novel insights about a disease process and not simply replicate data from other models.

The new finding is the latest evidence supporting a growing precision medicine model of psychiatric disease in which disruptions of certain genes during brain development contribute to a person's risk for multiple psychiatric disorders, with other genetic or epigenetic drivers, random developmental events, or environmental influences determining the specific disease an individual develops, said senior author Benjamin Cheyette, MD, PhD, an associate professor of psychiatry and a member of the UCSF Weill Institute for Neurosciences and the Kavli Institute for Fundamental Neuroscience at UCSF.

«I'm hopeful the techniques successfully used in this study can be applied to make animal models for other neurodegenerative diseases,» he says.

The researchers hope their new cell lines will be a useful resource for studying the cellular and molecular intricacies of Huntington's further, and suggest they may provide a model for examining other diseases of the brain that are specific to humans.

«Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities,» Perfect said.

But this remarkable therapeutic benefit isn't limited to MS. Previous research in animal models that mimic other diseases suggest that certain forms of amyloids can ease damage from strokes, traumatic brain injuries and even heart attacks.

«So now that we have seen this environmental toxicant - induced inflammation, we can study the beneficial anti-inflammatory foods, like the purple potato and others, in this human development model, and see how a mother's health and her levels of toxicants and beneficial compounds will influence the baby's susceptibility to chronic disease.»

Yet none of the models may be effective in demonstrating the way the cancer signals to other cells that tell the disease to grow.

They hope that these achievements might also serve as a model for improving the management of other disease stages and settings.

With these cells in hand, the researchers injected them into the lacrimal glands of mouse models of Sjogren's syndrome, an autoimmune disease that results in ADDE, dry mouth and other symptoms.

Now, after more than a decade, Prusiner and researchers at other laboratories have produced a simple model of how prions from a diseased brain could replicate.

Marsden, an assistant professor of mechanical and aerospace engineering at the University of California (UC), San Diego, is creating similar models for other heart conditions, including Kawasaki disease and coronary artery bypass grafting.

«The significance of this study expands beyond the limits of AHDS research, to the possibility of stem cell modeling the blood - brain barrier component in many other neurological diseases,» Vatine says.

In contrast, most lab - based medical researchers focus on a few genes or a particular disease model, blinding themselves to other possibilities, Butte says.

The next step will be to demonstrate efficacy in larger animal models, as well as test whether this approach can be used to protect against or treat other diseases.

«We desperately need new therapies for this disease, and regenerative medicine approaches have shown great promise in laboratory models and in clinical trials for other conditions.»