Ostrander says that by identifying
other dog genes for body size and for traits such as leg length and head shape, researchers may learn more about growth and its disorders — especially cancer — in humans and their best friends.
Not exact matches
Ko is working to adapt a procedure used so far in pigs, cows and
other animals to target
genes in cloned
dogs.
The small breed variant probably represses IGF1 and
other genes that cause larger breeds to grow, she says, adding that smaller
dogs have less IGF1 in their blood.
The team also found that two clusters of these
genes control different kinds of aggression: one directed at strangers and strange
dogs, and the
other directed at the owner and
other dogs in the household.
By comparing our genetic make - up to the genomes of mice, chimps and a menagerie of
other species (rats, chickens,
dogs, pufferfish, the microscopic worm Caenorhabditis elegans, the fruit fly Drosophila melanogaster and many bacteria), scientists have learned a great deal about how
genes evolve over time, and gained insights into human diseases.
A total of 21,257
genes were identified, a number similar to that of human beings and
other mammals, and they have been compared to those of cats, tigers, cheetahs and
dogs.
Previous studies have suggested, among
other things, that differences in
dogs» ability to communicate are associated with variations in the genetic material located close to the
gene that codes for the oxytocin receptor.
Based on the six
other published mammalian genomes (human, chimpanzee, mouse, rat,
dog and cow), the sequencers estimated that the feline genome contained some 20,000
genes.
One
gene that popped out was WBSCR17, suggesting that it or
other genes near it were important in
dog evolution.
Some
gene variants were found mostly in the friendly
dogs and wolves, while
others were found more often in unfriendly animals.
It's this diversity of looks that make man's best friend the perfect laboratory for connecting sets of
genes to particular traits and understanding the molecular mechanisms that govern variation in
dogs as well as humans and
other mammals.
On the
other hand, two Italian wolves with an unusual, black coat colour did not show any genetic signatures of hybridisation, except for carrying a
dog - derived variant of a
gene linked to dark colouration.
He and colleagues Lawrence Grossman and Derek Wildman compared approximately 10,000 protein coding
genes culled from the dolphin genome with comparable
genes from 9
other animals: a cow, horse,
dog, mouse, human, elephant, opossum, platypus and chicken.
Church said he also believed the alteration of
dogs and
other large animals could open a path to eventual
gene editing of people.
Assessment of aortic mRNA expression for
dogs with MPS I and VII, and mice with MPS VII has centered on quantification of cytokine, complement, and
other inflammation - related
genes [31 — 34].
The paucity of single nucleotide diversity among breeds is consistent with
other studies (29 — 32) and stands in stark contrast to the abundance of coding repeat variation we found in these same
genes known to be involved in the developmental processes under selection in the radiation in
dog breed morphologies.
Further, we show that the remarkable diversity of form in the
dog, in contrast to some
other species studied to date, appears to have a simple genetic basis dominated by
genes of major effect.
Researchers have identified the
gene mutation that causes NEwS, and a DNA test is now available that allows breeders to avoid producing affected puppies by never breeding two
dogs to each
other if they are both carriers of the abnormal
gene.
Methods.:
Dogs of various breeds, affected or unaffected with primary glaucoma, were genotyped for the Gly661Arg variant of ADAMTS10, as well as 7
other nonsynonymous single nucleotide polymorphisms (SNPs) in
other genes in the beagle POAG locus that segregate with disease.
Just because a
dog has the
gene for hip dysplasia however, does not mean he will be affected: the severity of the disease will be directly influenced by the
dog's diet and
other environmental factors such as exercise level or body condition — or so the theory goes.
Concurrently a study in Labrador retrievers has identified a mutant variant of ATP7B (Chr22) the Wilson disease copper transporter
gene in their affected
dogs while COMMD1 does not appear to be involved in affected
dogs in this and
other breeds.
On the
other hand, if the
dog's Pomeranian
genes are more dominant, then the
dog will look more like a Pomeranian.
This means there is not just one
gene that causes it and there are
other factors that influence whether your
dog goes onto develop «bad» hips.
A number of different breeds contributed to the
gene pool of the Rhodesian Ridgeback including the Bloodhound, Greyhound, Pointer, Mastiff, Airedale, and Africa's Hottentot
Dog, among
others.
Due to the high occurrence of health problems with the double merles in
other breeds we do not have or produce any
dogs in our program with the dominant merle
gene.
The same
genes (from related
dogs) keep on being bred to each
other, so there is no external blood and genetic material being added.
Remember that
dogs that carry this mutation also carry
other important good
genes that we do not want to lose from the breed.
The
dog's color can vary greatly with different mutated alleles on
other genes.
Since all
dogs with CEA have CH it can be managed in the same way one would manage any single
gene recessive trait even though
other as - yet unidentified
genes cause the more serious defects.
So if there were genetic characteristics that made «pit bulls» more prone toward aggression toward
other dogs, how long would it take for such a
gene to no longer exist through selective breeding.
As long as some
gene on a different chromosome does not interfere, all
dogs with the dominant KB allele would be black in those areas of the coat where «dark» is called for, such as all over in some breeds or the saddle in
other breeds.
Some
dogs are more affected by their
genes, while
other dogs are more affected by their environment.
I agree it's significant that
dogs have between four and 30 copies of the amylase
gene, and this wide range would indicate that some
dogs are much less able to handle starch than
others.
Dogs of these breeds should be tested for the
gene that causes copper storage problems, especially if they show evidence of jaundice, spontaneous bleeding or
other symptoms related to the disease.
Dog breeds such as Labradors, Beagles, and Shelties are more prone to obesity than
others, suggesting there is an inherited «fat
gene» in
dogs.
Although the mode of inheritance is recessive, male
dogs born from a carrier female require just one copy of the mutation, the
other gene linked to the X chromosome from which disease gets its name.
Bred to
other Irish marked
dogs, these
dogs may produce pieds, depending on the genetic makeup of their mate, while the SiSi
dogs can not provide a pied
gene, and will not produce pieds, even when bred to one.
In summary,
dog DNA testing is not based on individual
genes, but on «snips» which can carry similarities to
other breeds that look nothing like one another.
If we start to rule out potential breeding
dogs based on one failed
gene test, we may inadvertently increase inbreeding and the instance of
other mutations that we don't have tests for.
(ref) The problem is that some
dogs that carry these
genes will never develop the disease (incomplete or variable penetrance) while
others that appear free of those
genes develop cardiomyopathy (DCM) all the same.
Such a
dog could have a genetic make - up (genotype) that includes the
genes for
other colors.
This is due to the presence of the MDR1
gene that is also seen in
other herding
dogs including Australian shepherd, border collie, collie, Australian shepherd mini, English shepherd, McNab, Shetland sheepdog, old English sheepdog and breeds that are mixed with these.
This breeding should theoretically concentrate «Ch Blue Boy's»
genes slightly more than
other dogs in the pedigree.
Because some
dogs that carry
genes involved in SAS will be missed using the most current diagnostic tests - OFA or any
other certification of a puppy's parents is not an absolute guarantee that the disease can not occur.
The way the toy poodle breed (and all
other «toy» breeds) came into being was through selective inbreeding of the smallest
dogs in the litters; essentially the breeders applied their understanding of how mutations may be caused to engineering a specific mutation into a dominant
gene.
No, but she has inherited more wolf
genes than many
other dogs!
Coat color in
dogs is influenced by more than seven
genes, some of which actually mask the effects of
others).
This kind of protectionism, while understandable, keeps the
gene pool closed from even the introduction of new blood from
other countries that do have very respectable registries and healthy
dogs.
Amber - eyed
dogs have eumelanin pigment in their eyes, but not as much — probably because of
other genes which modulate how much is made.
The problem for some
dogs and Ivermectin (and many
other drugs for that matter) is that some
dogs have a
gene mutation that doesn't allow for the proper absorption of these chemicals in and out of the brain.