Sentences with phrase «other drug targets»
Eventually the promise of other drug targets, along with the possible side effects of targeting NPY, put a damper on the effort — until now.
https://www.scientificamerican.com/ Not exact matches
I won't reveal yet who my favorites are, but I will say that these young scientist - founders came up with very creative solutions for preventing infections in some common surgeries, tackling resistance in targeted antibody drugs, improving gene vectors for cell therapies, helping the vision - impaired «see» faces and better read their environments, imaging hard - to - see spots in the lungs and other organs, improving genetic risk analysis, and expediting the logistical operations of hospitals.
Managers killed those programs (including one highly anticipated drug aimed at coronary disorders that was about to head into human trials) and prioritized others where there was a clear genetic target for the drug.
While having genetic validation for a target is no guarantee of success — scientists still have to figure out how to drug the target safely and effectively, and meet myriad other biological challenges — it does offer a head start.
But I think it is long past time to consider the value of other approaches, including the targeted use of drug therapies.
neuro drinks are available at Target, Walgreens, Safeway, 7 - 11 and other national grocery, convenience and drug stores.
With the uncertainty over Paolo Guerrero following his drugs ban, and with no other proven target man to play up front, Peru may be tempted to recall their former captain, who was on standby for the play - off second leg against New Zealand.
You can find these gorgeous colors at various retailers including Target, Walgreens, Walmart, Rite Aid and other drug and mass retailers.
The investigation targeted drug suppliers from New York and around the nation — and even overseas — who are using the U.S. Mail to ship narcotics and synthetic drugs, along with other contraband, into the region.
NIU attorney's review search warrants to be presented to the courts of this county, and document that probable cause exists for the application for the warrant and that the target location, person, vehicle, etc. is entered into a law enforcement database called Unified Drug Enforcement Coordination System (UDECS) to prevent infringing on other agencies» investigations, and to enhance officer safety.
Rockland County District Attorney Thomas P. Zugibe on Wedesday announced the filing of criminal charges against 28 individuals on drug and other charges following a four - month undercover investigation targeting narcotics trafficking activities in the community.
County G.O.P. Chairman Mike Grasso said that the citizens of the county felt secure with the state of local law enforcement, particularly how York and his staff were concentrating on battling the spread of hard drugs in the county, and targeting other serious crimes.
Triple negative breast cancer is especially hard to treat because it lacks the receptors, such as the estrogen receptor, targeted with other cancer drugs.
Associate professor Mary - Ellen Taplin, of the Dana - Farber Cancer Institute, Boston, USA, will tell the 26th EORTC - NCI - AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, that galeterone was well tolerated by patients in the ARMOR2 trial, and also lowered PSA levels in a subset of men with CRPC that was resistant to other drugs that target the cancer, such as enzalutamide and abiraterone.
Moreover, the findings, if replicated in his and others» ongoing studies, could spur development of drugs that target HDL subclasses, working to raise HDL without apoC - III and lower HDL with it.
For this study the researchers targeted very specific types of GABA receptors to improve social behaviors with clonazepam, but the team also found that by using a different drug, they could target other GABA receptors and actually reduce the ability to socially interact in normal mice — underscoring that future medications would need to target very specific receptors so as not to diminish the drug's impacts.
Other trials of this drug target in lung cancer have not worked, and the drugs» effects in colorectal cancer are also questionable, Stambolic says.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.
The findings could offer scientists a new target for developing drugs against obesity and other appetite - related disorders, the researchers say.
That suggests that this sodium channel could be a target for the development of drugs to prevent the pain caused by acid build - up — which happens in arthritis and other inflammatory disorders.
She says a number of experimental drugs now in clinical trials are designed to target serotonin in other ways in the brain, and may have better success than the SSRIs.
But I should point out there are other drugs, particularly some of the drugs that target the vasculature, that cost $ 50,000 per year and are basically given continually after initial treatment.
Other researchers have already loaded hollow origami structures with drugs to target specific types of cancer cells, created DNA «robots» that walk across surfaces, and mimicked the shape of viruses.
The scientists believe the drug targets a stress pathway specific to alcoholics because it has been shown to have little effect on stress levels in other types of patients.
Elixir's approach is to provoke the same effect by delivering a drug that targets hormones, enzymes, and other proteins involved in metabolism.
Although other cancer - associated proteins have been successfully attacked with targeted therapies in recent years, the myc protein has continued to elude efforts to develop drugs that target it.
Several other drugs that inhibit the same biological target had already been approved for frontline CML treatment.
In some cases, the off - target effects of a drug could make it useful for treating conditions other than the one for which it was originally developed.
And as Deisseroth and his colleagues illuminate more neural pathways, other researchers will be able to design increasingly targeted drugs and minimally invasive brain implants to treat psychiatric disease.
Overall the findings suggest that granzyme A could serve as a potential drug target for anti-inflammatory treatments for chikungunya — and perhaps also for other inflammatory diseases.
These new findings point to GABA neurons as a new, neural drug target that could help treat the other patients who don't respond to today's treatment.
Because some of these neighbour proteins are as central and as global as the cancer - related proteins themselves, and link to so many other processes in the cell, there's a strong likelihood that drugs targeting them may have strong side - effects.
«Potential drug target against large family of parasites is identified: Researchers describe an enzyme that is likely vital for Plasmodium and other parasites of the Apicomplexan phylum.»
Fully understanding this process may present new target sites for drugs and may lead to better treatments for neurological diseases, cancers and other disorders.
But cardiologist Nilesh Samani of the University of Leicester in the U.K. says that the Danish group took «a fine approach» that can be applied to other biomarkers, especially before hundreds of millions of dollars are spent to develop drugs that target a molecule that may not in fact be causing a disease.
These were thought to be ketamine's target, but clinical trials of other drugs that target them have largely yielded disappointing effects on depression, says Gould.
Others modify the antibiotics» targets within the microbes or provide decoys that divert and disable the drugs.
Doing so enabled them to identify the liver - specific drug targets whose inhibition will not cause any side effect to other human tissues, says lead author Adil Mardinoglu, a SciLifeLab fellow, who had earlier established a connection between NAFLD and HCC and increased fat synthesis in liver tissue.
A new drug target to treat depression and other mood disorders may lie in a group of GABA neurons (gamma - aminobutyric acid - the neurotransmitters which inhibit other cells) shown to contribute to symptoms like social withdrawal and increased anxiety, Penn Medicine researchers report in a new study in the Journal of Neuroscience.
«Our research also shows that existing drugs can be repurposed to treat other diseases and once several potential drugs are found, we can redesign them to be more effective in combating their targeted diseases while reducing the side effects.»
Janssen and others have been pursing those receptors and proteins associated with them as potential drug targets.
A paper published in the November issue of the journal Microbe cites a potential new drug target, among other findings, as evidence that the risk was not taken in vain.
With this discovery, DYRK1A, known from past studies to drive cell division in other cell types, becomes a drug development target.
These drugs work by targeting the PDL - 1 receptor — a known immunotherapy biomarker for lung and other cancers — to boost immune responses to the cancer.
Other drugs in the pipeline also target the reward system, albeit through a different mechanism.
Unlike most other bioterror agents, H5N1 can be fought with vaccines and drugs, and can not be targeted to a specific population.
«Unfortunately, most cancer drugs have targets but those targets might be toxic when you inhibit them in other parts of the body.
«ALK now becomes the second abnormal gene that we are able to successfully target in lung cancer with drugs other than chemotherapy.»
It's a popular goal in nanotechnology these days: using tiny particles as containers to ferry drugs to tumors, among other targets.
«Investigating these pathways may identify other targets for therapy or other markers that predict treatment response,» says first author Theresa Wampler Muskardin, M.D., a rheumatologist at Mayo Clinic in Rochester, Minn. «It will help rheumatologists find the right drug for each patient and spare patients medications that won't work for them.»