Such studies integrate several research tools including classic animal dissections, histocytochemistry, immunohistochemistry, electron microscopy, kinematics & motion analysis, electromyography, and
other electrophysiological techniques.
A 50 % reduction in HDAC4 restored these and
other electrophysiological changes in both the R6 / 2 model, a transgenic over-expresser of Exon 1 HTT with an expanded polyglutamine repeat, and heterozygous Q175 knock - in mice (Q175 + / --RRB-, which carry one normal and one mutant HTT allele with an expanded repeat of ~ 190 polyglutamines, in addition to reversing behavioral alterations in R6 / 2 mice (Mielcarek et al, 2013; PLOS Biology, in press).
Not exact matches
Once on the
other side, interneurons form a circuit with — and quell the activity of — excitatory neurons in the cortexlike tissue,
electrophysiological tests suggest.
«Although responders and nonresponders both produce more electrical impulses and spontaneous activity, when we look at the
electrophysiological properties, the two groups are very different from each
other.»
Still
others are working to overlay gene - expression patterns,
electrophysiological measurements or
other functional data on those maps.
Interestingly, Ascl1 alone already induces neuronal properties, but co-expression of the
other factors strongly promotes a degree of differentiation, as you can see here in the acquisition of more mature
electrophysiological properties.
By
electrophysiological patch clamp recordings, we probe the response of neuronal model cells to photoexcitation by short light pulses, excluding
other pathways than a photoelectrical coupling, to be of passive nature only.
The ideal candidate will have a Ph.D. in Neuroscience, Biology, Psychology, Bioengineering, or
other closely related field, and will have expertise in conducting electrophysiology experiments as well as analyzing
electrophysiological signals from animal or human studies.