Sentences with phrase «other epithelial»

The observations made herein are unlikely restricted to only PC3 cells as Du145 holoclones can also be serially passaged and sustain long - term propagation (31) and many other epithelial cancer cells form holoclones that also express CSC markers such as CD44 (30).

Similar to primary keratinocytes, long - term — cultured squamous cell carcinoma (30) and many other epithelial cancer cells (30, 31) can also form different types of clones in culture.

Additional research will show whether other epithelial cells such as skin also partake of this self - healing method.

It may also represent a universal mechanism that regulates contractility in other epithelial tubes, including those found throughout our bodies.

This contraction is similar to that observed in other epithelial tubes.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

Not exact matches

Increasing Metabolism and Digestive Efficiency Other research suggests that capsaicin causes the stomach's epithelial cells to secrete more gastric mucus, the glycoprotein which lubricates food masses and facilitates their movement throughout the stomach.

Stem cells have also been identified in human milk, and have the potential to differentiate into mammary epithelial lineages under mammary differentiation conditions in vitro, as well as other cell types in corresponding microenvironments, including bone cells, brain cells, liver cells, pancreatic beta cells and heart cells.

In subsequent experiments, the Einstein team deciphered other parts of the Rac1 signaling cascade during invasion and showed that this signaling mechanism is regulated differently in normal breast epithelial cells.

«In our human airway epithelial model system, one of the drugs destabilizes and deactivates the protein that the other drug tries to correct,» said Martina Gentzsch, PhD, an assistant professor of cell biology and physiology and senior author of the UNC Science Translational Medicine paper.

Esrp1 and Esrp2 are active specifically in epithelial cells, which form the skin, the inner layers of the gut and lung, and other tissues in the body.

However, compared to other avian influenza viruses, the attachment to epithelial cells by H7N9 in the bronchioles and alveoli of the lung was more abundant and the viruses attached to a broader range of cell types.

The study, which followed four individuals for a year after they were treated with embryonic stem cell - derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.

But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the other by changes in epithelial cells.

The cell changes, known as an epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when cancer cells spread from the primary tumor site to other sites in the body.

Frequently, a virus will infect an epithelial cell, which compared with a nerve cells are «real virus factories,» says Schiffer: They produce massive amounts of virus that can infect other nearby epithelial cells and can presumably also infect sexual partners.

The team's findings may also be relevant to inflammatory disorders that affect other parts of the body, such as the linings of the gut and bowel, which, like the skin, are replenished by epithelial stem cells.

Unrestrained epithelial cell extrusion has been linked to tumor cell invasion and metastasis in other studies.

«An immediate use of our study will be to look into other human epithelial tissues to see if this finding is unique to the breast or a more general phenomenon,» says Dr. Gilley.

When they mimicked physical damage to the epithelial layer, heregulin made its way to the other sides, activated erbB2, and stimulated cell growth.

Among other things, this means CFTR loses the ability to control a protein called the epithelial sodium channel (ENaC).

Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.

Corresponding to the primary function of epithelial tissues, i. e. forming a barrier between compartments, epithelial cells form tight adhesions between each other, and display only lateral mobility, confined by the basement membrane.

As anticipated from the identification of Lgr5 + as a marker of ASCs in multiple other tissues, a similar approach proved successful in generating organoids or tumoroids from virtually any epithelial organ or tissue (2,3).

Inside the epithelial cell, the tail of E-cadherin binds to a protein called α - catenin, which recruits other proteins that spur assembly and disassembly of actin filaments and is absolutely critical for strong adherence between epithelial cells.

Our Intestine - Chip also allows researchers to culture intestinal epithelial cells alongside other cell types, such as immune cells, and analyze how these different cell types interact.

As a proof - of - concept of the atlas's utility as a reference for disease studies, the researchers also surveyed gut epithelial gene expression in two models of intestinal infection, one of Salmonella bacteria, the other of Heligmosomoides polygyrus, a species of helminth (an intestinal parasite).

Scientists taking a close look at how a dangerous food - borne bacterium invades the gut have identified a new culprit, a molecule that normally helps hold the intestinal lining and other sheets of epithelial cells together.

Data from the laboratory shows that signals from these molecules through their receptors control the activities and long - term survival of T cells, as well as affecting the activities of other cell types including dendritic cells, macrophages, and epithelial cells.

The role of these molecules in driving disease pathology might vary, with described activities of HVEM signaling promoting T cell expansion or survival, analogous to certain activities of OX40 and 4 - 1BB, and other activities of HVEM or LTβR increasing the function of diverse cells such as stromal cells, dendritic cells, macrophages, eosinophils, epithelial cells and keratinocytes.

Distinctive functions of alpha6beta4 and other integrins in epithelial cells.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Cancer cells acquire the ability to invade and migrate, or metastasize, to other tissues, through a process called Epithelial - Mesenchymal Transition (EMT).

Among other things, when the embryon grows into a fetus, the ectoderm gives rise to the central and the peripheral nervous system, the mesoderm gives rise to connective tissue, the kidneys and the bones and muscles, and the entoderm gives rise to the epithelial lining of the gastrointestinal and respiratory tracts, the liver and the pancreas.

Female athletes are at risk for common nutrient deficiencies, such as low protein, low iron, low calcium, and low vitamin D. (3) When active women don't eat enough nutrients, or they are poorly absorbed due to increased intestinal permeability (leaky gut), SIBO, SIFO, or other causes of intestinal epithelial inflammation, they are not nourished enough to sustain intense exercise over time.

If you (or anyone else reading this) can show me a study where they did the same tests as on animal fats etc. on cold pressed virgin coconut oil and demonstrated that it actually damaged the epithelial cells rather than just extrapolating from tests on other oils, I would greatly appreciate it.

The epithelial lining of the small intestine, aside from being designed to absorb nutrients along its twenty - foot length, has many other actions.

Other tests your doctor may use to evaluate your magnesium status include a 24 - hour urine test or a sublingual epithelial test.

The byproduct of the urease and stomach acid is toxic to epithelial cells as are the other chemicals produced by this bacterium, leading to damage to cells, a disruption of tight junctions and inflammation.

They have tentacle like protrusions that penetrate the tight junctions between the epithelial cells, through to the other side, and use these tentacles to take external surface antigens back in for destruction.

A diet high in animal food is necessarily high in Insulin — Like growth factors one and two, (IGF I, II), epithelial growth factor, Transformation growth factors A, B., and others.

Meconium is the greenish mix of bile, amniotic fluid, bile pigments, epithelial cells, mucus, blood and other substances found in the first stool of a newborn.

It is likely that the metabolic syndrome may extend to other chronic illnesses and conditions that are widely prevalent in Western societies, including: myopia (80), acne (81), gout (79), polycystic ovary syndrome, epithelial cell cancers (breast, colon, and prostate), male vertex balding, skin tags and acanthosis nigricans (78).

The most common cause of obstruction is a urethral plug, which consists of mineral crystals (e.g., struvite, calcium oxalate), white blood cells, red blood cells, protein (mucus), and epithelial cells.5 The underlying cause of urethral plugs is unknown; however, plugs have been linked to struvite crystalluria — suggesting that diet may play a role — and idiopathic cystitis.6 Other causes of urethral obstruction include urethral edema and spasm associated with lower urinary tract inflammation and pain.7 Uroliths, neoplasms, and urethral strictures can also lead to urethral obstruction; however, they are reported less frequently than other cauOther causes of urethral obstruction include urethral edema and spasm associated with lower urinary tract inflammation and pain.7 Uroliths, neoplasms, and urethral strictures can also lead to urethral obstruction; however, they are reported less frequently than other cauother causes.5

Other ophthalmic signs can include keratitis (inflammation in the cornea) and corneal ulceration due to the direct cytopathic effect on epithelial cells.

Hypovitaminosis A in cats may exhaust vitamin A reserves of the kidneys and liver; affect reproduction to cause stillbirths, congenital anomalies (hydrocephaly, blindness, hairlessness, deafness, ataxia, cerebellar dysplasia, intestinal hernia), and resorption of fetuses; and cause the same changes in epithelial cells noted in other animals.

The viral infection mostly targets the respiratory and gastrointestinal tracts of dogs, although there is an increasing incidence of canine distemper that invades the brain and spinal cord as well as other organs and tissues of the body such as optic nerves, urogenital structures, and epithelial tissues.

These growths originate in the epithelial tissue of a gland beneath a nipple and eventually spread (metastasize) to the lymph nodes, lungs, pleura, liver, adrenal gland, kidney, or other parts of the body.