The observations made herein are unlikely restricted to only PC3 cells as Du145 holoclones can also be serially passaged and sustain long - term propagation (31) and many
other epithelial cancer cells form holoclones that also express CSC markers such as CD44 (30).
Similar to primary keratinocytes, long - term — cultured squamous cell carcinoma (30) and many
other epithelial cancer cells (30, 31) can also form different types of clones in culture.
Not exact matches
But by hierarchical clustering of observed alterations in endocytosis, the researchers identified two distinct
cancer phenotype clusters, one marked by mutations in the oncogene KRAS in mesenchymal cells and the
other by changes in
epithelial cells.
The cell changes, known as an
epithelial to mesenchymal transition, or EMT, are normal and helpful during wound healing, but problematic when
cancer cells spread from the primary tumor site to
other sites in the body.
Cancer cells acquire the ability to invade and migrate, or metastasize, to
other tissues, through a process called
Epithelial - Mesenchymal Transition (EMT).
It is likely that the metabolic syndrome may extend to
other chronic illnesses and conditions that are widely prevalent in Western societies, including: myopia (80), acne (81), gout (79), polycystic ovary syndrome,
epithelial cell
cancers (breast, colon, and prostate), male vertex balding, skin tags and acanthosis nigricans (78).