Not exact matches
Esrp1 and Esrp2 are active specifically in
epithelial cells, which form the skin, the inner layers of the gut and lung, and
other tissues in the body.
«An immediate use of our study will be to look into
other human
epithelial tissues to see if this finding is unique to the breast or a more general phenomenon,» says Dr. Gilley.
Corresponding to the primary function of
epithelial tissues, i. e. forming a barrier between compartments,
epithelial cells form tight adhesions between each
other, and display only lateral mobility, confined by the basement membrane.
As anticipated from the identification of Lgr5 + as a marker of ASCs in multiple
other tissues, a similar approach proved successful in generating organoids or tumoroids from virtually any
epithelial organ or
tissue (2,3).
Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal
epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the
tissue and disseminate to
other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.
Cancer cells acquire the ability to invade and migrate, or metastasize, to
other tissues, through a process called
Epithelial - Mesenchymal Transition (EMT).
Among
other things, when the embryon grows into a fetus, the ectoderm gives rise to the central and the peripheral nervous system, the mesoderm gives rise to connective
tissue, the kidneys and the bones and muscles, and the entoderm gives rise to the
epithelial lining of the gastrointestinal and respiratory tracts, the liver and the pancreas.
The viral infection mostly targets the respiratory and gastrointestinal tracts of dogs, although there is an increasing incidence of canine distemper that invades the brain and spinal cord as well as
other organs and
tissues of the body such as optic nerves, urogenital structures, and
epithelial tissues.
These growths originate in the
epithelial tissue of a gland beneath a nipple and eventually spread (metastasize) to the lymph nodes, lungs, pleura, liver, adrenal gland, kidney, or
other parts of the body.