Sentences with phrase «other gene regions»

Not exact matches

DNA - testing companies determine where your genes are from by comparing you to other users who are known to have ancestors from that region.

Vast rice - growing regions in India, Bangladesh, and other countries, which are submerged during rainy season and rendered useless for rice production, have been made productive since the SUB1 gene that makes rice flood - tolerant was discovered and bred into popular existing rice varieties.

While they don't have definite answers, besides having good genes, Kawas said, the answer is probably a combination of being resilient to Alzheimer's Disease and also that they did not develop other dementia - causing conditions, such as microscopic infarctions that occur when blood flow is blocked from certain regions of the brain and hippocampal sclerosis, which causes neuron loss.

This finding suggests that the homologous region may have resulted from a duplication of an ancestral gene and that the two genes evolved further by recruitment of exons from other genes, which provided the specific functional domains of the LDL receptor and the EGF precursor.

They add that other genes in the region of the genome around Gp - 9 are probably involved in regulating fire ant social organization as well.

It found that genes associated with depression are involved in brain cell development, and that there was overlap between these genetic regions and those linked to schizophrenia and other mental illnesses.

They lie in a region of chromosome 5 that sits squarely between two genes that produce cell - adhesion molecules, which govern how neurons connect to each other.

Mutation around the region of the human SOX9 gene, which encodes the Sox9 protein, causes campomelic dysplasia, a congenital disease that is accompanied by skeletal abnormalities and other conditions.

Another doubled - up region contains enhancers that turn on some genes in the cerebellum, a part of the brain that coordinates movement, speech and performs other important functions.

Using Epiviz and Bioconductor, the research team found consistent regions of DNA methylation changes in colon cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer types.

By comparing this region with the DNA from epileptics from six other families, the researchers gradually homed in on a gene called KCNQ2.

Despite differences in brain size, the researchers found striking similarities between primate species of gene expression in 16 regions of the brain — even in the prefrontal cortex, the seat of higher order learning that most distinguishes humans from other apes.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

Early comparative studies threw conserved regulatory regions, RNA genes, and other features into relief, bringing meaning to much of our genome, including the 98 % that lies outside protein - coding regions.

Nobody knows why an invertebrate should need such a gene, but the fact that its various coding regions are organised in a subtly different way from those of all other known globin genes is forcing a rethink about the evolutionary history of globin genes.

But genetic mapping places it in a region with at least 20 other genes, and discovering which of these is the right one could take years of painstaking work.

But in the so - called junk DNA — 98 % or so of the genome — it's likely that we'll find other conserved regions that aren't in genes.

But genes in other regions are so close together they overlap: the cluster of 75 genes which determines tissue type and plays a part in controlling our immune responses is packed into only 4 million base pairs.

In other words, DNA in the Hox - D region encodes timing information which ensures that the genes are activated at precisely the right moment during development.

Then that region expands, and new islands harboring other divergent genes emerge, creating islands of speciation across the genome.

Basically, the gene makes a molecule involved in preparing other genes for expression, helping to distinguish between regions of genes that should be manufactured and those that are silent genetic filler.

Sometimes cells make the correct amount anyway; other times CNVs affect DNA regions that regulate the expression of still other genes, making the problem more complicated.

Informally called jumping genes, these bits of DNA can replicate and insert themselves into other regions of the genome, where they either lie silent, doing nothing; start churning out their own genetic products; or alter the activity of their neighboring genes.

Yet in sub-Saharan Africa and other regions where it is endemic, «people have already developed 25 new genes that protect against malaria, including the Duffy blood type, an entirely new blood group,» he notes.

It scans a very broad area of the genome (508 genes and more than two million base pairs or letters of the genome, i.e.. A, T, C, and G) with high accuracy (each region of the genome is sequenced or «read» 60,000 times), yielding about 100 times more data than other sequencing approaches.

By also examining this genetic region in two other families with similar disorders, the researchers were able to pinpoint a mutation in a specific gene, NT5E, which is involved in breaking down calcification in the arteries.

Twin genes or duplicated regulatory regions result, and although one in the pair usually has to keep doing its original job, the other is free to mutate and take on new roles that can enhance an organism's survival.

CREs are regions of genome DNA that do not code for proteins, and control morphology and other traits by regulating genes.

Dudley's team found that HAR - associated schizophrenia genes are found in regions of the genome that influence other genes expressed in the prefrontal cortex, a brain region just behind the forehead that is involved in higher - order thinking.

Some occur in genes that play a role in skeletal growth and development, which makes sense, but others lie in genes that trigger cancer or in undeciphered regions of DNA.

Because people in a region are more likely to marry and mate with each other — a factor that may be largely due to shared language — that gene pool will evolve as a separate cluster that corresponds to a place on the globe, he explains.

This is important because knowledge of the way DNA folds inside the cell allows scientists to study how specific genes, and the DNA regions that control them, interact with each other.

In one species, the black snub - nosed monkey (about 2,000 individuals are found in the wild), they identified several hypoxia - related genes that allowed them to thrive in the highest altitudes (a narrow region 3,400 - 4,500 meters above sea level in a narrow region between the Yangtze and Mekong rivers within the Tibetan plateau) than any other nonhuman primate.

The paper finds that MMR preferentially repairs genes, rather than other regions of the genome.

Using genes from these chromosomal regions, Richter identified three new enzymes that function in terpene synthesis pathways to produce linalool, nerolidol, and other terpenes.

This optimization was based on combining very stringent selection criteria (minimal secondary structure, minimal homology to other genes in the available rat genomic databases, no low complexity or repeat regions, and defined Tm) with a statistical ranking algorithm [48].

Light red or light blue regions indicate positive or negative outlier expression, respectively, of the gene relative to the other lines shown; z - score of a positive outlier in the corresponding cell line is in dark red and a negative outlier is in dark blue.

During specification of SM identity, bd1 mRNA accumulates in a boundary region between the indeterminate meristem and differentiating lateral organ, where it is predicted to suppress ectopic expression of other meristem identity genes in the SM.

These genetic variations were found in regions of the DNA that were near genes involved in Parkinson's disease and other brain disorders.

Two clock proteins, CLOCK (Circadian locomoter output cycles protein kaput) and BMAL1 (Brain and Muscle Arnt - like1) bind to each other to form a heterodimer complex, which then binds to a DNA sequence called E-box (CACGTG) located in the upper region of clock genes, Per (Period) and Cry (Cryptochrome), present in the genome.

This indicates that a comprehensive and experimentally supported annotation effort of the human genome simultaneously highlights regions with striking differences in gene organization to other species and may indicate evolutionary events specific to the human lineage demanding further functional analyses.

The dogma of DNA methylation is that it generally represses gene expression — in other words, methylated regions are transcriptionally silent, and unmethylated regions are often transcriptionally active.

Preferential integration into 5» non-coding regions is also observed with the yeast Ty1 transposon and other retroelements in studies analyzing inactivated genes (31).

All of the significant regions had been previously reported / validated; they included or were proximal to a number of well - known cancer genes including EGFR, CCND1, KRAS, MDM2, PDGFRA, and others.

Other techniques can also edit genes at specific DNA regions.

The sliding window approaches nicely captured association over the LPA gene region, but also in other nearby regions, some of which were also supported by the first - intron or regulatory - motif analyses.

Such an allelic chromatin organization might be present at other DMRs as well, and a recent study by Schweizer et al. (2) shows that the imprinting - control region in the 5 % portion of the SNRPN gene has strong hypersensitive sites on the unmethylated maternal chromosome only.

A minimum of two pairs of primers spanning the RRM region and other regions were used to confirm the expression of the Boule gene (Table S4).

Other molecular mechanisms linking the cloned 13.5 kb ws1 region to wing size evolution could also occur, including cis - regulation of prospero, changes in non-coding RNAs, or long - distance regulation of another gene.

Kaghad M, Bonnet H, Yang A, Creancier L, Biscan JC, Valent A, Minty A, Chalon P, Lelias JM, Dumont X, Ferrara P, McKeon F, Caput D. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.