Sentences with phrase «other gene variants»

Other gene variants associated with the function of T - cells, an immune system workhorse, would later come to light.

Because you have her whole genome, and not just a test for a single gene, you can potentially look for a vast number of other gene variants that raise the risk of other diseases of adulthood, such as the BRCA1 gene for breast cancer.

So are several other gene variants.

Genetic factors can contribute to the degree of longevity in at least two important ways: An individual may inherit certain genetic variations that predispose him or her to disease that decreases longevity; other gene variants may confer disease resistance, thereby increasing it.

Other gene variants — like mutations in FTO or the gene for leptin, an energy - balancing hormone — had been linked to overeating or fat cell type.

Not exact matches

These genes are implicated in highly penetrant genetic disorders for which surgical or other interventions aimed at preventing or significantly reducing morbidity and mortality are available to pathogenic variant carriers.5 Identification of a pathogenic variant in one of these genes could be diagnostic of a medical condition with potential implications for an individual's medical management.

Every gene in (almost) every cell of the body is present in two variants — so called alleles: one is deriving from the mother, the other one from the father.

The handful of cases that still occur are most likely to affect non-Jews, families carrying mutations other than the distinctly Ashkenazi variants of the Tay - Sachs gene.

An apparently new Variant of human serum albumin, albumin Naskapi, has been found in high frequency in the Naskapi Indians of Quebec and, in lower frequency, in other North American Indians.The family and population data of the albumin are consistent with its inheritance as a simple autosomal trait Controlled by a gene designated Al Naskapi.

We show that Neandertals shared more genetic variants with present - day humans in Eurasia than with present - day humans in sub-Saharan Africa, suggesting that gene flow from Neandertals into the ancestors of non-Africans occurred before the divergence of Eurasian groups from each other.

Luckily, along came Armstead and his colleagues, who were working to precisely locate the sequence of a gene called staygreen (sgr) in the meadow grass Festuca pratensis, some variants of which remain green in drought and other unfavorable conditions because they are unable to break down a green pigment.

The small breed variant probably represses IGF1 and other genes that cause larger breeds to grow, she says, adding that smaller dogs have less IGF1 in their blood.

The IGF1 protein is crucial for the growth of mammals, including mice and humans, so Ostrander's group and other collaborators began collecting DNA from additional breeds to see if they also shared the same gene variant.

On the other hand, gene variants that confer a benefit to males are more likely to accumulate on the X chromosome than on a nonsex chromosome because they will always be expressed on a male's single X chromosome.

«In the current study, we analyzed dozens of variants of those genes and other genes frequently associated with obesity risk and saw that, while total fat intake was related to higher BMI, people who were genetically predisposed to obesity and ate the most saturated fat had the highest BMIs.»

Gusella explains that the presence of two modifying variants on chromosome 15 — one associated with symptoms appearing an average of six years early, the other associated with an average one - and - a-half-year delay — implies that there may be two actual modifying variants that both influence one modifier gene but in opposite directions.

Alzheimer's - Of the three variants of the ApoE gene, ApoE4 carries the highest risk for late - onset Alzheimer's (other genes are associated with early - onset Alzheimer's).

Here's a gene that's central to how nerve cells communicate with each other, so it's curious to us to see a grossly different protein variant.

In all, the study included the data of more than 23,000 people to show that approximately 12 percent of a person's variation in delay discounting can be attributed to genetics — not a single gene, but numerous genetic variants that also influence several other psychiatric and behavioral traits.

Gene variants have been linked to elevated risks for disorders from Alzheimer's disease to breast cancer, and they may help explain why, for example, some smokers develop lung cancer whereas many others don't.

By 12 months of age, infants with this gene variant whose needs were consistently attended to responded to stress just as effectively as did the babies with other versions of the gene.

The CREBRF variant appears to be rare in other populations, but studying how the gene works may help researchers better understand obesity.

(The other four EBV proteins had no interaction with the variant genes.)

In this research, the group looked at two variants of miR - 21, a microRNA «oncomiR» known to target tumor suppressor genes and which is highly expressed in a number of cancers as well as other proliferative diseases such as psoriasis.

The study, which has identified more than 200 rare variants inherited by children, determines that genes YWHAZ and DRP2, among others, are new candidates in the research on autism genetic basis.

What we need to do now is to see if other circadian gene variants in association with different stress factors cause the same effect.

Fifty - four per cent were single gene mutations, and the other 13 per cent were polygenic DNA variants, meaning they were a combination of multiple bad genes inherited together.

Instead, gene variants will need to be introduced by hybridization with other diverse strains of S. cerevisiae, says Borneman, such as those found in natural fermentations of African palm wine and other environmental isolates.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

The company is looking to incorporate other genes, too, such as a gene variant that makes fruits change colour more dramatically as they ripen.

Mice prefer the smell of other mice with different variants of MHC genes to their own and tend to confirm this preference by mating with mice possessing dissimilar MHC genes.

A follow - up study of 96 other patients with Alzheimer's disease confirmed that this HLA variant is associated with earlier onset of Alzheimer's, although Payami cautions that another gene very close to HLA - A2, and not HLA - A2 itself, could be at fault.

But he adds that genes are «team players,» and that SNVs that are benign in isolation could cause disease when accompanied by other detrimental variants.

Some of the letter variants were inside a gene, while others were near key genes.

Researchers have identified a gene variant which explains why some patients with Parkinson's Disease respond well to drug treatment and other do not.

Those differences led to lower levels of the IFITM3 protein in ndividuals with two copies of the high - risk gene variant compared to other patients, researchers said.

Thomas and his colleagues began this study by searching for other possible IFITM3 variants that correlated with gene expression, levels of the IFITM3 proteins and were common in flu patients in the U.S..

The genes have many different working variants, but one variant of each gene is much more common than all the others.

Equally interesting is that the gene variant occurs in 47 percent of the population — in other words, it is just one contributing factor, and it probably works in concert with other vulnerability genes.

Other variants of the hemoglobin gene also confer some protection against malaria.

If, say, an unexpected adverse event pops up in a human trial, the informaticians can then sift animal, lab, and human data to investigate the possibility that certain gene variants or other factors predispose patients to the adverse event.

The team then put either one variant or the other variant of the gene back in and again grew the plants in low - iron conditions.

Seedlings (bottom) and roots (top) of Arabidopsis thaliana plants reveal that one variant of FRO2 gene (right) is better for growth in low - iron conditions than the other FRO2 variant (left).

As sequencing improves, people will face the possibility of other unsavoury gene variants being spotted unexpectedly as a result of sequencing.

The other finding was of a variant near genes for several so - called semaphorins, proteins that guide developing nerve cells as they grow toward their final targets.

One of their findings was a variant in a gene called Ret that had not been previously associated with the disease, although other variations in Ret had been fingered as culprits.

«GECCO aims to continue to discover additional colorectal cancer - related variants by investigating how genetic variants are modified by other environmental and lifestyle risk factors, including biomarkers as well as how they influence patient treatment response and survival,» Peters said, emphasizing how much further research is required to uncover the specific mechanisms by which genes modulate the intake of certain foods on colorectal cancer risk.

Additional studies showed that other CYP gene variants are linked to the rapid metabolism of clopidogrel and that patients with those variants had a higher risk of bleeding.

Other characteristic patterns of variants included genes involved in immune system activity and the fat content of breast milk.

Researchers have found a variant gene in schizophrenics that appears to be implicated in defective working memory and other cognitive problems that characterize the disease.