Over the past decade Hariri has looked for evidence of how
other genes affect other aspects of our minds, including self - control and memory.
The researchers plan to investigate what percentage of individuals individuals with intellectual disability and autism may carry CC2D1A mutations and to determine whether
other genes affect neurons in a similar fashion.
Not exact matches
Habit then uses blood samples and DNA from a cheek swab to glean details on glucose levels and obesity - related
genes, among
other factors that could
affect metabolism.
Before this can happen though, Teixeira said that his team will first have to determine whether the Stk11
gene or the
other genes and proteins it controls are similarly
affected in the human form of BPH.
The handful of cases that still occur are most likely to
affect non-Jews, families carrying mutations
other than the distinctly Ashkenazi variants of the Tay - Sachs
gene.
Unlike
other autoimmune disorders with associated risk factors, APECED is clearly caused by a mutation in a single
gene, based on analyses of
affected families.
Other directions for future research, Liu said, include looking at the role of CLOCK in more forms of the disease, learning more about exactly how CLOCK
affects neural circuits to disrupt adequate inhibition of excitatory neurons, and examining whether any of the
genes that CLOCK regulates are especially important in the disorder.
But many of the
genes that
affect lifespan in worms
affect lifespan in
other organisms.
Affected family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown
gene that appears to code for a transcription factor — a protein that switches
other genes on or off.
Hockemeyer says that it's unlikely to be another mutation, but rather an epigenetic change that
affects expression of the telomerase
gene, or a change in the expression of a transcription factor or
other regulatory proteins that binds to the promoter upstream of the telomerase
gene.
Transcription - factor
genes code for proteins that regulate the activity of
other genes and so
affect an animal's ability to respond to its environment.
The researchers can't rule out that the
other genes also
affect beak size, but say HMGA2 is the
gene most strongly associated with the trait.
They looked at
other genes that interacted with TAK1 kinase including activators and inhibitors of the TAK1 pathway and found that most of them also
affected regeneration, but only when worms were infected.
George Bray, who heads the clinical obesity and metabolism department at Louisiana State University, says environment and behavior — like lack of access to exercise facilities and overeating — so strongly
affect gene activity that you can not focus on one while ignoring the
other.
The
genes that
affect hair colour also
affect other cancer types, while
other pigment
genes affect the chances of having Crohn's and
other forms of bowel disease.
«Such changes may
affect other genes as well; we haven't studied all the potential targets yet.
To figure out how corn and weeds
affect each
other's
gene response, Clay and a team of two research associates and a soils expert, planted plots of velvetleaf alone, corn with velvetleaf and corn kept weed - free.
Or, the
other likely explanation, the drugs are working through the host and could be
affecting host proteins or
genes so that the bacteria can not use them to reproduce, Chopra said.
The research suggests that reducing production of the protein, called myoferlin,
affects cancer cells in two primary ways: by changing the activation of many
genes involved in metastasis in favor of normal cell behavior, and by altering mechanical properties of cancer cells — including their shape and ability to invade — so they are more likely to remain nested together rather than breaking away to travel to
other tissues.
White and her colleagues set out to identify how FoxP2
affects thousands of
other genes in zebra finches before and after the critical period for learning closes.
«Patients» individual genomes may
affect efficacy, safety of
gene editing: CRISPR - Cas9 and
other gene editing systems may need to be customized to the patient.»
A new study of more than 6000 pairs of twins finds that academic achievement is influenced by
genes affecting motivation, personality, confidence, and dozens of
other traits, in addition to those that shape intelligence.
Research from
other scientists at Johns Hopkins, he says, had suggested that some tumors, particularly those that
affect the nervous system, have mutations in the ATRX
gene, which produces proteins that appear to maintain the length of telomeres, repetitive segments of DNA on the ends of chromosomes that typically shorten each time a cell divides.
«A
gene that
affects how well an individual does in one environment or the
other might
affect how they see each
other and how they mate with each
other.»
In fish larvae without the EGFL7
gene, however,
other genes compensate for the loss, so that the inhibitor hardly
affects the growth of blood vessels (below).
The
gene affects credit - card debt the way
other genes have been found to play a role in breast cancer: a particular version of the
gene increases risk, but many
other genetic and environmental factors are important, too.
One of the «hits» was Lhx1, a member of a family of
genes whose protein products
affect development by controlling the activity of
other genes.
Sometimes cells make the correct amount anyway;
other times CNVs
affect DNA regions that regulate the expression of still
other genes, making the problem more complicated.
DNA methylation and
other epigenetic alterations — chemical changes to DNA that can alter a
gene's expression without
affecting its protein - coding sequence — may underlie some of the lasting biochemical havoc, Ghanei says.
Also, unlike chemical manipulators that diffuse throughout a cell, light can be applied to specific
genes without
affecting other parts of the cell.
«We are hopeful that a systemic dose and delivery of
gene therapy would broadly affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Instit
gene therapy would broadly
affect whole - body strength and function, and we are working on a host of projects for such systemic delivery in Pompe and
other neuromuscular conditions,» said Barry Byrne, M.D., Ph.D., director of the Powell
Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Instit
Gene Therapy Center, a professor of pediatrics in the UF College of Medicine, and a member of the UF Genetics Institute.
«A couple of
other genes are also evolving rapidly and we know nothing about them,» he says, adding that they may
affect the behavior of hemagglutinin.
The
gene in question is for a chemical transporter that fine - tunes transmission of serotonin, the neurotransmitter
affected by the antidepressant Prozac and
others of its ilk.
«This tells us that the NuRD complex is very influential — not only does it
affect the activity of
genes directly, it also controls
other regulators of multiple
genes,» Bonni said.
One of them had a deletion on chromosome 22 that
affected, among
other genes, SHANK3, which has been implicated in mental retardation.
A new study finds that academic achievement is influenced by
genes affecting motivation, personality, confidence, and dozens of
other traits, in addition to those that shape intelligence.
CSIC researcher adds: «We have confirmed that mutation is found in both copies of the
gene, one inherited from the father and the
other one inherited from the mother, in the four women
affected by the disease, causing an absolute absence of STAG3 protein and meiotic cohesin complex in these women.
Altogether, they found nearly 1,000
other poplar
genes whose activity is
affected by EBB1.
The regulation of the CAMP
gene by vitamin D was discovered by Gombart, and researchers are still learning more about how it and
other compounds
affect immune function.
On the
other hand, the
gene Trypsin - 7 appears to
affect the recognition potential, thus enabling — at least in part — the identification of the host colonies required for a raid,» adds Feldmeyer in summary.
The Arizona researchers studied whether cage conditions
affect mice with one copy of a
gene called fibulin - 4, a member of a family of
genes believed to code for proteins that stabilize the connective tissue found between cells in arteries and
other blood vessels.
Normally, FOXP2 coordinates the expression of
other genes, but in
affected members of the KE family, it was broken.
There are some data on how groups of
genes are impacted by one chemical, and
other genes are
affected by different chemicals.
Still, Dudley feels that evolutionary genetic analysis can help identify the most relevant
genes and pathological mechanisms at play in schizophrenia and possibly
other mental illnesses that preferentially
affect humans — that is, neurodevelopmental disorders related to higher cognition and GABA activity, including autism and attention - deficit / hyperactivity disorder.
Viewed this way, humans can be considered to have lost two
genes — one
affecting uricase and the
other affecting the ability to produce vitamin C — whose absence helped our ancestors during famine but, in today's world, may be increasing our risk for obesity and diabetes.
Clock
genes are extremely influential,
affecting the activity of most
other genes in the body in one way or another.
Other medical sequencing projects will use DNA sequencing to: discover new
genes that are involved in common diseases; identify the
genes responsible for dozens of relatively rare, single -
gene (autosomal Mendelian) diseases; sequence all of the
genes on the X chromosome from
affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in
genes known to contribute to certain common diseases.
Although TMAdV was found to be highly divergent from
other adenoviruses, different isolates of TMAdV from 3
affected titi monkeys were remarkably conserved, sharing 100 % identity across the full - length hexon
gene (data not shown).
Both groups took measurements to see whether
other genes were being
affected by the zinc - finger drug, and found results that were broadly reassuring.
The current work shows that changes in the genetic code of a particular
gene can control epigenetic marks at different
genes, implying that a
gene's genetic code can
affect whether
other genes are turned on and off, which makes it important to understand the function of all
genes involved, not just the one with the so - called misspelling.