Sentences with phrase «other genes linked»

Since the identification of erp, researchers have found other genes linked to the bug's virulence.

The other gene linked to the disorder, BMPR2, is thought to cause PAH by ultimately promoting growth and multiplication of smooth muscle cells in the pulmonary artery, thereby restricting blood flow.

Although the mode of inheritance is recessive, male dogs born from a carrier female require just one copy of the mutation, the other gene linked to the X chromosome from which disease gets its name.

Not exact matches

Genes for deafness, meanwhile, are linked with one or more of the genes associated with at least twenty other ailmGenes for deafness, meanwhile, are linked with one or more of the genes associated with at least twenty other ailmgenes associated with at least twenty other ailments.

The burly bull's outsized legacy was made possible in part by careful record - keeping and, later, applied genetics, in which farmers select cattle whose genes — like Chief's — are linked with high milk production and other valuable attributes.

The markers have also been used to produce a detailed map of the sugarcane genome that shows how the genes are linked to each other.

Studies on genes, brain structures and hormones have failed to identify a clear link between, on one hand, differences at birth between the sexes and, on the other, particular behaviour.

In addition to the new work's potential for RS, there is speculation that it could pave the way to treatments for other neurological disorders, such as learning disabilities, schizophrenia, autism and newborn encephalopathy as well as some mental retardation that has also been linked to the Mecp2 gene.

For example, the gene has also been linked to serious depression in some studies and to cognitive ability in others.

The researchers identified for the first time master genes that they believe control hundreds of other genes which are linked to Alzheimer's disease, Parkinson's disease, post-traumatic stress disorder, stroke, attention deficit hyperactivity disorder, autism, depression, schizophrenia and other disorders.

Rare mutations that shut down a single gene are linked to lower cholesterol levels and a 50 percent reduction in the risk of heart attack, according to new research from Washington University School of Medicine in St. Louis, the Broad Institute at Massachusetts Institute of Technology and Harvard, and other institutions.

Most cases of familial hypolipidemia are linked to other gene mutations that cause liver and digestive problems, but in members of this American family with the condition, Musunuru found mutations in the gene for ANGPTL3, and no associated health problems.

It found that genes associated with depression are involved in brain cell development, and that there was overlap between these genetic regions and those linked to schizophrenia and other mental illnesses.

Other gene variants — like mutations in FTO or the gene for leptin, an energy - balancing hormone — had been linked to overeating or fat cell type.

PARP inhibitors are used primarily to treat tumors linked to defects in BRCA genes, but may show promise in other cancers when combined with other drugs.

Trent and others says that the same mechanism might be at work in genes linked to other cancers, such as breast and prostate cancer, which have been found to contain similar «harmless» sequence variations.

Modern chickens carry a version of the thyroid - stimulating hormone receptor gene, TSHR, that has been linked to several domesticated chicken characteristics: year - round egg laying, faster egg production at sexual maturity, reduced aggression toward other chickens and less fear of people.

Other researchers had linked the ank mutation to mouse chromosome 15; in this week's Science, Kingsley's team reports that it's a single typo in a previously unknown gene, which they called ank, that led to a protein about 10 % shorter than the normal version.

In addition to the Great Danes, researchers, including Laporte, have found Labrador retrievers that bear two other gene mutations that cause different forms of recessive centronuclear myopathy, one linked to chromosome 2 and the other to the X chromosome.

Gene variants have been linked to elevated risks for disorders from Alzheimer's disease to breast cancer, and they may help explain why, for example, some smokers develop lung cancer whereas many others don't.

Many other genes have been linked to cleft lip or palate, and the researchers hope to understand if these additional genes are also associated with enhanced tooth decay.

Ressler then wanted to see whether Oprl1 could be linked to PTSD in humans, so looked at the gene's sequence in approximately 1,800 highly traumatized civilians, some of whom had PTSD and others who did not.

The team cut and pasted a bovine gene for NRAMP1, a protein linked to resistance against TB and other bacterial infections, into fetal dairy cow genomes.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

The link to autism suggests that a therapy that resets gene behavior in fragile X syndrome may also ease other developmental disorders.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

At the core of this cell behavior is how the loss of that single gene changes activation levels of dozens of other genes, suppressing genes associated with metastatic disease and increasing activity of genes linked to normal tissue.

This work is part of the ongoing Duke Neurogenetics Study (DNS), a comprehensive study linking genes, brain activity and other biological markers to risk for mental illness in young adults.

Researchers also found higher levels of expression of the gene MET, which is linked to autism spectrum disorder, in the human prefrontal cortex compared to the other primates tested.

Results from the analysis confirmed previous findings of some copy number variants already associated with autism, but they also found a host of other genes (SHANK2, SYNGAP1, DLGAP2 and the X chromosome — linked DDX53 - PTCHD1 locus) in which mutations seem to be linked to autism.

«This is a very important discovery that will guide future research efforts to explore the interactions of these pigmentary genes with other genetic and environmental risk factors in cancers not linked to sun exposure, such as eye melanoma.

The research team is now looking more closely at other genes that are linked to mental disorders.

Drawing on ADNI data, which helped link Alzheimer's disease to a common gene called CLU, researchers used this imaging technique in other people to discover that the brain wiring of gene carriers is impaired decades before the disease typically strikes.

For instance, the human network consists of over 18000 genes / proteins connected to each other with over 4 million links.

Microglia are activated during Alzheimer's disease progression and may mediate an initially protective inflammatory response, a notion that is also supported by epidemiological studies linking mutations in the TREM2 gene to increased risk of Alzheimer's and other neurodegenerative diseases.

«This technique will be useful for other studies interested in characterising the link between gene expression and physical, external traits.»

To gain access to the gene - containing portion of the barley genome at high resolution, Close and his team identified and sequenced 15,622 BACs or bacterial artificial chromosomes — small fragments of the barley DNA linked to other DNA to constitute a circular molecule that can replicate and be propagated inside an E. coli bacterial cell, enabling researchers to produce copies of each BAC for DNA sequencing one small piece of the barley genome at a time.

Other companies, including Myriad itself and Ambry Genetics, along with academic medical centers, have jumped in with panels of dozens of genes linked to an array of cancers.

The findings were surprising to the group, as no other animal has been found to have a sex - linked difference in the make - up of its eye that depends on the suppression of an opsin gene.

Other genetic defects associated with hypertrophic cardiomyopathy — six different genes have been linked to the disease — may work similarly by producing abnormal proteins involved in contraction, says Sweeney.

Other HOX gene members are linked to feather development, such as HOXC8, which is associated with a crest of feathers on top of the head.

Previous evidence for a breast cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in human breast cells, which is expressed in some breast cancers.

«This is an important finding that will help future researchers, and eventually physicians, to maximize the effectiveness of gene therapy for curtailing sensory deficits associated with USH3 syndrome and, perhaps, in other disorders linked to defects in single genes,» said Alagramam.

Additional studies showed that other CYP gene variants are linked to the rapid metabolism of clopidogrel and that patients with those variants had a higher risk of bleeding.

In tests using human neural progenitor cells (NPCs)-- self - renewing, multipotent cells that generate neurons and other brain cell types — the scientists found that exposure to sofosbuvir not only rescued dying NPCs infected with the Zika virus, but restored gene expression linked to their antiviral response.

Both genes, called DRD4 and DEAF1, have already been linked with novelty seeking in people, fish and other birds.

Another surprising finding was the direct link between Notch and genes involved in other B cell signaling pathways.

That's a marked difference from smoking, the only other consumption behavior that has been linked to certain genes, says Abraham Palmer, a pharmacogeneticist at the University of Chicago in Illinois who studies how genes regulate the effects of amphetamine.

In 77 families, they did not find BRCA mutations, but did find changes in other genes they say are definitely linked to breast cancer, such as TP53 and CHEK2.

Others were found in genes encoding regulatory proteins that are linked to psychiatric illnesses such as schizophrenia and the developmental disorder Smith — Magenis syndrome.