Sentences with phrase «other genetic line»

One type of mice were genetically inclined to binding ICZ with AHR while the other genetic line of mice were not so inclined to bind ICZ with AHR.

Not exact matches

He carried one genetic mutation that in modern humans raises the risk of coronary heart disease by 40 per cent, and two others that made him prone to a build - up of fat in the linings of his arteries.

«We used different lines of evidence to show that ANGPTL3 deficiency is associated with a reduced risk of coronary artery disease,» said study co-author Kiran Musunuru, MD, PhD, MPH, an associate professor of Cardiovascular Medicine at Penn. «But ultimately we were able to identify that fact that carriers of this genetic mutation did in fact experience a benefit — with little other health risk.»

Moreover, the results may transcend the bloating and discomfort of lactose intolerance: The technique could serve as a way to transform the gut lining into a factory for replacing missing proteins in other genetic disorders such as hemophilia, says pulmonologist Eric Alton of the Imperial College School of Medicine in London.

Yesterday, another Harvard team announced that it had generated disease - specific cell lines for nine other genetic diseases, including Parkinson's disease.

Molecular biologist Matt Kaeberlein of the University of Washington in Seattle says the results are in line with work from his lab showing that slight differences in growth conditions, the genetic makeup of the yeast or other factors can change the outcome of the experiment.

In experiments with cancer cell lines, the PIM1 inhibitors killed cells in a MYC - dependent manner, and in two different mouse models — one in which mice were implanted with patient tumors and the other in which a genetic alteration of MYC predisposes the mice to tumor development — the administration of PIM1 inhibitors resulted in significant tumor regression.

To make sure that the differences were really due to the DISC1 variation and not to other genetic differences, graduate student Ha Nam Nguyen spent two years making targeted genetic changes to three of the stem cell lines.

But other genetic data suggests that at least one high - elevation gene appeared in Tibetans only between 2750 and 5500 years ago — more in line with the appearance of high - elevation agriculture on the plateau.

And the genetic makeup of the flies also mattered, because lifelong antibiotic treatment caused one normally long - lived mutant line to die at the same age as normal flies given antibiotics — in other words, its life span was extended only in the presence of bacteria, the researchers report in this week's issue of Proceedings of the National Academy of Sciences.

Also, certain maize centromeres in some lines have virtually undetectable amounts of CentC [5] while homologous centromeres of other lines contain numerous copies of the centromeric satellite and are present at the same genetic location [24].

It should be noted that the phenotype of this C57BL / 6J - congenic line (Stock No. 028867 Gad2 - IRES - Cre knock - in (C57BL / 6J)-RRB- could vary from that originally described for mice on other genetic backgrounds.

In the next decade, molecular research is going to further develop along five lines: predictive medicine, that investigates the genetic conditions predisposing to tumor risk; early molecular diagnosis; the evaluation of each patient's prognosis based on his / her genetic profile, in other words, the analysis of what kind of mutation affects the DNA of altered cells; the investigation of the individual response to drugs, based on our genetic knowledge; «smart drugs», molecules able to hit the target in a selective way, killing only the deprogrammed cells.»

hPSCreg provides comprehensive information on existing hPSC lines, their ethical procurement, derivation process, genetic and expression data and other molecular or biological characteristics, use and quality of the line.

We seek to have a better understanding of the genetic basis and physiological mechanisms of yield potential, from which we develop elite inbred rice lines with about 10 % higher yield potential and possess other important traits.

Jumping LINE - 1s — and other genetic parasites like it — are responsible for about one in every 250 disease producing mutations in humans.

Yes, the two conditions (bicuspid or other aortic valve defect and weakening of the adjacent segment of the aorta) indeed tend to go together — but perhaps only because of a predisposition to aortic weakening (thought to be caused by hydraulic abnormalities in flow from the diseased valve); perhaps the predisposition need not be fulfilled if the artery and its lining are healthy as a result of adequate diet — just as a genetic predisposition to heart disease in general need not result in actual disease if diet is adequate.

However, there is currently no scientific proof that this condition exists in any dog or cat breed, other than one genetic line of Irish Setters.When a furkid has soft stools, flatulence, foul poop or itchy skin, most paw - rents immediately assume that the food is the culprit.

The hound and pointer crosses have also been referred to as Alaskan Huskies, but many became concerned with the growing lack of huskyness among these crosses, and so they are now trying harder to emphasize the «Husky» portion of these dogs (They appear more like the working line of Siberians and other breeds that originally formed their genetic makeup).

In popular (or rare) inbred and line bred animals, the breed in general can be at increased risk, because of the genetic predisposition that promotes an adverse response to viral or other infectious agent challenge (Dodds, 1983, 1999).

On the other hand, breeders who are producing mixed breeds might have a bias against purebreds because they believe the rate of inbreeding and line breeding in a closed gene pool (when breeders stick to only breeding dogs registered with a specific kennel club, that breed's gene pool is most likely closed) will create a genetic bottleneck.

More than most other breeds, how a Chihuahua turns out depends largely on the genetic temperament of his parents and grandparents (entire lines are social or antisocial) and how it is raised (socialization and training) when brought home.

An inherited early - onset form of diabetes characterized by abiotrophy of islet β - cells in a line of Keeshond dogs (128), is a rare example of an «other specific type» of canine diabetes and presumably has a genetic basis.

Other problems are due to founder effects and other genetic bottlenecks created by close line breeOther problems are due to founder effects and other genetic bottlenecks created by close line breeother genetic bottlenecks created by close line breeding.

English Cocker Spaniels, like many dog breeds that originated as working dogs, have some genetic lines that focus on working dog skills and others that focus on ensuring that the dog's appearance conforms to a breed standard.

Hip dysplasia tends to be more common in some breeds than others and in some lines than others, which indicates that there is a genetic component to the disorder.

Fortunately, population genetics theory suggests that breed - characteristic behaviours should not be «lost» from lines of dogs selected for other traits (such as conformation), unless there is active natural selection against them or unfavourable correlated genetic response from selection on other phenotypes.