To determine whether the reactivation of methylation - silenced genes by EGCG is a general phenomenon that also occurs in other cell lines, we studied the effects of EGCG treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three
other human cancer cell lines (Fig. 3C) ⇓.
Not exact matches
Using this biosensor in highly invasive breast
cancer cells taken from rodents and
humans, the Einstein team discovered that when an individual invadopodium forms and is actively degrading the ECM, its Rac1 levels are low; on the
other hand, elevated Rac1 levels coincide with the invadopodium's disappearance.
The researchers have shown that it is possible to produce chromosome modifications in
human cells that are genetically identical to those observed in leukemia and
other types of
human cancer.
When the scientists inserted
human colorectal
cancer cells into zebrafish embryos and allowed them to grow for 4 days, the resulting tumors showed three hallmarks of
human solid tumors: rapid
cell division, formation of blood vessels to supply nutrients, and the ability to spread to
other locations in the body.
Then the researchers turned to the lab, where they exposed
human liver, breast, colon, ovarian, and
other cancer cells to the drugs, which appeared to make it easier for the
cells to migrate.
Working with
human breast
cancer cells and mouse models of breast
cancer, scientists identified a new protein that plays a key role in reprogramming
cancer cells to migrate and invade
other organs.
By using molecular genetic tools to reduce the amount of PC in
human lung
cancer cells, the team observed decreased
cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and
other cells), and a reduced rate of tumor growth in mice.
«In people chronically infected with hepatitis B or C,
human papillomaviruses or
other viruses known to cause
cancer, radioimmunotherapy could potentially eliminate virus - infected
cells before they're able to transform into
cancer cells.»
The transplantation of isolated
human hematopoietic stem
cells is used in the treatment of anemia, immune deficiencies and
other diseases, including
cancer.
Singletary added sulforaphane, a chemical in broccoli, kale, brussels sprouts, and
other cruciferous vegetables, to cultures of
human breast
cancer cells.
Researchers suggested that
other classes of inhibitors be tested in combination with ERK5 inhibitors in
human colorectal
cancer cells in preclinical mouse models before any patient trial can begin.
«Our work outlines the genetic similarities of the tissue and
cells in different types of tumors and shows the strong relationships mice can have to
other human cancers too.»
According to its developers, the technique can be applied to assess mutation dynamics in
other types of
cells, even
human cancer cells.
The results of this original study are highly relevant to
other human diseases that dependent on genome instability, such as fungal infection or
cancer, and open new venues for anti-leishmanial drug discovery using host - directed strategies that target the parasite's metabolic dependence on the host
cell, thus preventing the adaptive evolution of drug resistant parasites.
The study of
human astrocytes has faced issues related to access (samples of living tissue must be obtained from brain
cancer or epilepsy surgeries or fetal tissue) and purification (breaking apart astrocytes away from
other cells often killed them and many experiments ended in failure).
Previous evidence for a breast
cancer link has been mixed — one study found increased risk in women exposed before age 14, whereas
others found no association — but in a lab dish, DDT has been shown to activate the HER2 gene in
human breast
cells, which is expressed in some breast
cancers.
This study, which will be published Oct. 24 in eLife, and two
other new Northwestern studies in Oncotarget and
Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple
human genes and their powerful effect on
cancer in mice.
After confirming in mouse models that
cells from HER2 - positive breast
cancers became resistant to anti-HER2 treatment when implanted into the brain but not into
other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast
cancers from both mice and
human patients.
For more than 25 years, scientists examining cultures of
human cancer cells have occasionally spotted
cells tucked within
other cells.
The example shown reveals that these estrogen agonists show the strongest connectivity to each
other in MCF7, a
human breast
cancer cell line that expresses the estrogen receptor.
A strain of bacteria that commonly lives on the
human skin produces 6 - HAP that can kill
cancer cells without harming
other cells.
Still, he said, the new data, «has important implications for understanding the genesis of
cancer and the interaction between
human cells and
other microbial or viral organisms in or around us.»
Health improvement (allowing to post - pone / escape the diseases and thus live, healthier / disease - free longer, but not above
human MLSP of around 122 years; thus these therapies do not affect epigenetic aging whatsoever, they are degenerative aging problems not regular healthy aging problem (except OncoSENS - only when you Already Have
Cancer - which cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to
Cancer - which
cancer increases epigenetic aging, but cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to
cancer increases epigenetic aging, but
cancer removal thus does not change anything / makes no difference about what happens in the other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to
cancer removal thus does not change anything / makes no difference about what happens in the
other cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to M
cells / about what happens in the normal epigenetic «aging» course in Normal non-cancerous healthy
cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to M
cells) Although there is not such thing as «healthy aging» all aging in «unhealthy» (as seen from elders who are «healthy enough» who show much damage), it's just «tolerable / liveable» enough (in terms of damage accumulating) that it does not affect their quality of life (enough yet), that is «healthy aging»: ApoptoSENS - Clearing Senescent
Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to M
Cells (this will have great impact to reduce diseases, the largest one, since it's all inflammation fueled by the inflammation secretory phenotype (SASP) of these senescent
cells) AmyloSENS - Dissolving the Plaques (this will allow humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to M
cells) AmyloSENS - Dissolving the Plaques (this will allow
humans to evade Alzheimer's, Parkinsons and general brain degenerescence, allowing quite a boost; making people much more easily reach the big 100 - since the brain is causal to how long we live; keeping brain amyloid - free and keeping our memories / neuron sharp / means longer LongTerm Potentiation - means longer brain function means longer heavy brain mass (gray matter / white matter retention seen in «sharp - witted» Centenarians who show are younger brain for their age), and both are correlated to MLSP).
The study relates to a particular type of vaccine (killed) against a particular virus, influenza, though the findings might hold true for
other killed vaccines and for those vaccines consisting only of proteins produced by GM in bacteria, yeast or insect
cells, against diseases such as hepatitis B (HBV) and
human papilloma virus (HPV, the causative agent of cervical
cancer).
The answers they have discovered so far reveal critical information about gene regulation; specifically, that
cells are used to record the positional identity in
human tissues, and that the «perturbation,» the disturbance, of such programs plays a major role in
cancer progression, especially in metastasis, whereby
cancer cells spread to
other parts of the body.
Muehlenbachs said further investigation is needed to determine whether it is limited to tapeworms or whether the situation is worse — that there's some «underlying biological phenomena» that might lead to transmissible
cancer cells developing in
other creatures that can pass them along to
humans.
Because programmed
cell death goes awry in leukemias and
other cancers, Hu is currently examining lincRNA - EPS's function in normal and diseased
human cells in an effort to determine whether it plays a role in tumor development and growth.
Antioxidants and
other active components of prickly pear induced early
cell death in
human breast and colon
cancer cells, with a more pronounced effect occurring in colon
cancer cells.
I said in the introduction that
cancer is a disease in which
cells lose their «humanness» — their proclivity to collaborate with
other human cells to create a
human organism.
In an in vitro study, vanillin induced apoptosis and arrested the
cell cycle of
human colorectal
cancer cells, and some researchers think vanillin could reduce the metastatic potential (ability to spread to
other parts of the body) of
human cancer cells in vivo, too.
We know that the bodies of both
humans and rats have natural self - repair mechanisms that not only fight
cancer cells, but
other disease.
It rebalances acid / alkaline in the system and may help prevent
other cancers by inducing apoptosis in
human skin, thyroid, gastric, liver, colon, cervical and prostate
cancer cells.
There are also petri dish studies that suggest gamma oryzanol may help lower cholesterol, and along with
other compounds found in the rice bran, which is what makes brown rice brown, may inhibit
human cancer cell growth through antioxidant means, anti-proliferative and pro
cancer cell suicide mechanisms, immune system modulation, and increasing barrier protection, but again this is all just in test tubes, not people.
Currently, her lab is focused on finding drugs suitable for eliminating mammary
cancer and ocular herpevirus infections in small companion animals, and evaluating the effectiveness of stem
cell therapies for treating skin wounds in horses — all of which may also be used in
humans and
other animals.