Boosting these animals with
other immunogens may drive these antibodies to further mutate into the longsought bNAbs.
Not exact matches
GL B21 on the
other hand bound to both
immunogens (Fig. 7A, B) although to a lesser degree than B21 (Fig. 2A, B) which has additional mutations within the V gene.
Dr. Schief's work focuses on computation - guided and structure - based design of
immunogens and immunization regimens, with the goal of inducing broadly neutralizing antibodies against HIV and
other pathogens that have frustrated traditional vaccine design strategies.
The
other is a so - called «germline - targetting»
immunogen that is engineered to induce the earliest precursors of a specific class of bNAbs.