Sentences with phrase «other ion channels»

Otopetrins are structurally different from all other ion channels, and all of the otopetrins form proton channels, suggesting that these proton - conducting channels are evolutionarily conserved.

Other ion channels respond to mechanical force.

When stimulated, the cells» channels open up within microseconds, much faster than most other ion channels in the body.

Not exact matches

These results led to three conclusions about the chemical nature of ion binding sites in the conduction pathway: The channel contains two identical titratable sites, even though there are more than two (probably four) identical subunits; the sites are formed by glutamate residues that have a pKa (where K (a) is the acid constant) of 7.6; and protonation of one site does not perturb the pKa of the other.

Since neurons can be depolarized by calcium and other positively charged ions, such as those the TRPV1 channel controls, we hope that this system may be effective at regulating neural activity.»

Ion channels are generally selective for certain ions, allowing specific types of ions to flow through at very high rates, while hindering the flow of others.

Future studies will focus on using these nanobowls to deliver anle138b to the brain, as well as other diseased tissues and organs affected by toxic amyloid - beta ion channels.

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

In us and other mammals, that message increases the activity of a molecular pore, called the TRPV1 ion channel, causing the cell to become more sensitive to touch or heat.

This is a significant step toward real biomedical application of anion transporters in the battle against cystic fibrosis and other diseases caused by faulty ion channels.»

It uses a virus already approved by the Food & Drug Administration for other genetic therapies in the eye; it delivers an ion channel gene similar to one normally found in humans, unlike others that employ genes from other species; and it can easily be reversed or adjusted by supplying new chemical photoswitches.

«These effects happen at the minute level of potassium, chloride, and other ions moving across the neuron outer membrane via channels and transporters,» Dani said.

The researchers studied calcium channels in neurons, which allow for the transport of calcium ions from one nerve cell to another, helping the cells transmit itch signals from the skin to other cells in the spinal cord.

Many other chemicals are capable of blocking ion channels, he says, and «there is reasonable, if not compelling, evidence that a reduction in excitation is as much a part of the olfactory [sense] as excitation itself.»

When nerve cells receive a signal of pain or other sensation, the signal opens sodium channels and floods the cell with positively charged sodium ions, which positively charge the neurons until the electrochemistry changes enough to inactivate the channels and close them.

Future therapies will have to be based on strategies that act by reducing or increasing the number or activity of specific subtypes of pre - and postsynaptic receptors, transporters, and ion channels, or other membrane molecules at the synapse, and by strategies that exploit the new possibilities offered by stem cell technology and targeted repair.

Known key pathological mechanisms are related to defects in structural proteins, nuclear proteins, intermediate filaments and other cyoskeletal proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.

UNC0642 exhibits an in vitro IC50 < 15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins.

Hopefully these results may accelerate the development of treatments for pain that selectively target Nav1.7 and aid drug design efforts aimed at other voltage-gated ion channels.

The Lexicon efforts are focused on gene families that are pharmaceutically important, such as transporters, G - protein coupled receptors (GPCRs), ion channels, kinases and other key enzymes, membrane proteins (e.g., receptors), and secreted proteins.

It is tantalizing to speculate that amiodarone HCl might also be toxic to other stem cell populations that demonstrate increased ion channel expression relative to their differentiated derivatives, including mesenchymal stem cells (MSCs) and endothelial precursor cells [36], thus expanding the utility of the automated screening assay described here.

ëinhibitory effect of metal ions, alone or combined, on sodium channels (research indicate that body's radical quenchers like glutathione, L - cysteine and EDTA can prevent or reverse such inhibition by «friendly» metals like zinc, copper, iron and cobalt, but not that caused by heavy «metals like lead and mercury), possible inhibition of sodium channel activity by dopamine, and others.

The big thing most cord - cutters want is continued access to their favorite channels and shows, which typically air on local broadcast television affiliates of ABC, CBS, FOX, NBC, Univision, PBS, ION and others.