Sentences with phrase «other isoform»
Whereas acute CD8 + T cell effector responses are enhanced in DGKζ - deficient mice postinfection with intracellular pathogens, persistent memory formation is impaired, most dramatically when both DGKζ and DGKα, the other isoform of DGK that metabolizes DAG downstream of the TCR in T cells, are deleted (35, 36).
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These varying combinations lead to the generation of slightly different proteins known as isoforms, which can end up functioning differently from each other.
Among the other genes she says play a role in thoroughbred performance are peroxisome proliferator - activated receptor - γ coactivator - 1 alpha (PGC - 1α), which is involved in skeletal muscle adaptation to exercise; pyruvate dehydrogenase kinase, isozyme 4 (PDK4), involved in glucose regulation, expression of which increased almost fourfold after sprints; and cytochrome c oxidase subunit 4 isoform 2 (COX 4I2), involved in respiration.
In the course of screening over 180 mutant mouse strains with a systematic battery of behavioral tests, Dr. Tsuyoshi Miyakawa and his colleagues found that mice with heterozygous knockout of the alpha - isoform of calcium / calmodulin - dependent protein kinase II (αCaMKII) exhibit behavioral deficits and other brain features consistent with bipolar disorder.
Buy human recombinant laminins from BioLamina - culture stem cells, differentiate to neurons, RPE cells, cardiomyocytes and other cells on their specific laminin isoform.
At least six isoforms of actins are known in mammals and other vertebrates: alpha (ACTC1, cardiac muscle 1), alpha 1 (ACTA1, skeletal muscle) and 2 (ACTA2, aortic smooth muscle), beta (ACTB), gamma 1 (ACTG1) and 2 (ACTG2, enteric smooth muscle).
This work is currently complemented by the characterization of new CA isoforms and other actors of Ci transport in scleractinian corals.
Regarding other members of the p53 family, the p63 gene encodes 6 isoforms which migrate on gels in sizes from 32 - 90 kDa [21,30].
Intense efforts have been underway to identify antagonists that selectively inhibit only the Nav1.7 channel but leave the other eight human Nav channel isoforms unaffected.