Sentences with phrase «other key gene»

In addition to its effect on the insulin pathway, the let - 7 microRNA appears to drive these metabolic and functional changes by acting on other key gene regulators.

Not exact matches

In other words, these four genes likely play a key role in the biology of the disorder.

One of the key caveats at the time, however, was that the technique required the use of a virus to introduce several genes into the skin (or other) cell, and these would remain in the cell, and so might contaminate the resulting stem cell or create cancer risks.

Other factors such as hormones and genes also cause hair loss, but the key factor is the deficiency in nutrients.

That entailed, among other things, splicing in rat genes that direct the production of dopamine, a key intermediate in noscapine synthesis.

One key gene encodes the making of a receptor called TREM2, a docking site for molecules on the surface of microglia and other innate immune cells.

The second gene, TNFRSF6B, encodes a receptor related to those that bind tumor necrosis factor (TNF)-- a key chemical signal for triggering inflammation in IBD as well as in patients with other autoimmune disorders such as rheumatoid arthritis and psoriasis.

In other words, the key is not in individuals» genetic make - up but rather, in how their bodies employ genes.

A key challenge is that, at least in developed countries, deaf people tend to marry each other, thus mingling many genes for impaired hearing.

Scientists have identified genes that are active during puberty, but most also have key functions in other basic processes, such as regulating fat.

The Van Allen Probes are a great mission, and part of that credit goes to the late Gene Heyler [who passed away in March 2013], who designed the orbits so that the satellites lap each other several times per year, which has been a key to the science results the mission can achieve.

The authors conclude that the study of marine mammals is just the first demonstration of this new evolutionary approach, and is versatile enough to be applied to many other emerging questions concerning key genes involved in the diversity of life.

Now, Mitchum's team is trying to find how this key gene might work differently in other nematode types, like root - knot nematode as part of a new National Science Foundation grant.

«Now that we know how calcification happens and what the key nodes are, we know what genes to look for that might be mutated in other related forms of cardiovascular disease.»

Some of the letter variants were inside a gene, while others were near key genes.

«In mammals, in the absence of haploid cells, other approaches have been used to identify key genes, such as interfering RNA, but they are sub-optimal methods.

Two key events enabled organelles to develop: The precursor bacteria transferred many of their genes to the host's genome, and they developed a method of transporting the proteins produced by these and other genes back inside their own membranes.

A key hurdle for the team was to create enzymes that could copy a gene from a DNA molecule to an XNA molecule, and other enzymes that could copy it back into DNA.

Researchers investigating pediatric low - grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer.

The HLA (human leukocyte antigen) is a system of genes responsible for regulating immune responses, and peptides are short chains of amino acids that play key roles in regulating the activities of other molecules.

In a race with other scientists, Scottish researchers have bred mice with an altered gene which displays all the key features of cystic fibrosis, such as lung disease and digestive problems.

In one of the most elaborate feats of synthetic biology to date, a research team has engineered yeast with a medley of plant, bacterial, and rodent genes to turn sugar into thebaine, the key opiate precursor to morphine and other powerful painkilling drugs that have been harvested for thousands of years from poppy plants.

Based on studies of other genes related to FOXP2, the authors suggest that the loss of functioning protein from one copy of this gene might disrupt the proper growth of key speech and language structures in the brain.

Some researchers have argued that endogenised retroviruses may be key to how species diverge from each other, by activating different body plans and gene networks that may give one individual an edge over other members of the species.

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

He cloned and characterized many of the genes that are key in the regulation of glucose metabolism including insulin, glucagon, glucose transporters and many others.

Known key pathological mechanisms are related to defects in structural proteins, nuclear proteins, intermediate filaments and other cyoskeletal proteins, mitochondrial energy production and ion channels, but new concepts and new genes are rapidly being identified.

These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.

Some of the key genes produce waterborne pheromones, used by the barnacles to attract each other, which allows them to attach to surfaces close to each other where they will be able to mate.

Key proteins involved in gene expression depend on each other when forming a heart in an embryo, but, if left alone, they start to run amok

«The NFT is thought to be more closely related to memory decline than other forms of aging - related pathologies, but there are still very few genes that have been implicated in the accumulation of this key feature of Alzheimer's disease and other brain diseases.»

Nevertheless, sponges share key adhesion and signalling genes7, 8,9,10,11 with eumetazoans, as well as other genes important in body plan patterning such as developmental transcription factors12, 13,14,15; sponge embryos and larvae (Fig. 1) are readily comparable to those of other animals12, 16.

The Lexicon efforts are focused on gene families that are pharmaceutically important, such as transporters, G - protein coupled receptors (GPCRs), ion channels, kinases and other key enzymes, membrane proteins (e.g., receptors), and secreted proteins.

Drug developers, meanwhile, are exploring compounds that may be capable of thwarting epigenetic modifications that cause key genes to become under - or overactive, thereby promoting cancer and other diseases.

To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found having a high number of interacting partners (i.e., a high degree of connectivity), which indicates high local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.

And for a vegan bodybuilder who must unfortunatelly play tetris with the food sources that he choses in order to give to his body the right ammounts of aminos, restricting SPI and soy foods so much does not make his goal any easier.There are sometimes that you need a meal thats complete with aminos and soy provides that meal with the additional benefits of lacking the saturated fats trans cholesterol and other endothelium inflammatory factors.I'm not saying that someone should go all the way to 200gr of SPI everyday or consuming a kilo of soy everyday but some servings of soy now and then even every day or the use of SPI which helps in positive nitrogen balance does not put you in the cancer risk team, thats just OVERexaggeration.Exercise, exposure to sunlight, vegan diet or for those who can not something as close to vegan diet, fruits and vegetables which contains lots of antioxidants and phtochemicals, NO STRESS which is the global killer, healthy social relationships, keeping your cortisol and adrenaline levels down (except the necessary times), good sleep and melatonin function, clean air, no radiation, away from procceced foods and additives like msg etc and many more that i can not even remember is the key to longevity.As long as your immune system is functioning well and your natural killer cells TP53 gene and many other cancer inhibitors are good and well, no cancer will ever show his face to you.With that logic we shouldn't eat ANY ammount of protein and we should go straight to be breatharians living only with little water and sunlight exposure cause you like it or not the raise of IGF1 is inevitable i know that raise the IGF1 sky high MAYBE is not the best thing but we are not talking about external hormones and things like this.Stabby raccoon also has a point.And even if you still worry about the consumption of soy... http://www.ncbi.nlm.nih.gov/pubmed/21711174.

A protein that appears to play a key role in the formation of lymphoma and other tumors by inhibiting a tumor - suppressing gene has been identified by a team of veterinary and human medicine researchers at the University of California, Davis.