Sentences with phrase «other lymphoid»

Lymphoma is cancer of the lymph nodes or other lymphoid tissue such as the spleen or tonsil.

Lymphocytes constantly circulate through blood vessels within lymph nodes and other lymphoid organs, but only some actually enter lymphoid tissue by crossing the walls of the vessels, known as high endothelial venules (HEVs).

The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other lymphoid organs but also other tissues.

Not exact matches

The research suggests there are more people infected in lymphoid tissues, who may never develop the disease but could still infect others via blood transfusions or organ donations

They also found that 1,4 - BQ was more toxic to HSCs, myeloid progenitors (which give rise to red blood cells and platelets, among others) and B cell lymphoid progenitors than it was to T cell lymphoid progenitors.

«The fundamental «killing units» of CD4 T cells in lymphoid tissues are other infected cells, not the free virus,» says co-first author Gilad Doitsh, PhD, a staff research investigator at the Gladstone Institute of Virology and Immunology.

Using mice bred to lack some types of lymphoid cells, among other features, researchers were able to show that those mice still had high levels of suPAR and proteinuria, indicating that lymphoid cells were not the perpetrators of kidney disease.

Diagnosis of BPDCN was confirmed by the positivity of the cells for CD4 and CD56, along with other markers that are more restricted to plasmacytoid dendritic cells (such as CD123), and the negativity of the cells for lymphoid, NK and myeloid lineage - associated antigens.

The diagnosis of 6 cases were as follows; three diffuse large B cell lymphomas, two mucosa - associated lymphoid tissue lymphomas and one of other B cell neoplasias.

A fact sheet about the relationship between H. pylori infection and gastric cancer, gastric mucosa - associated lymphoid tissue (MALT) lymphoma, and other cancers.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Lymphoid cells are different from the other somatic cells in the body.

Amplification of the JAK2 locus has been described in Hodgkin disease and mediastinal B - cell lymphoma, 18,19 and biallelic inactivating mutations in suppressor of cytokine signaling - 1 (SOCS - 1), a negative regulator of JAK2, have been identified in mediastinal B - cell lymphoma.20 Genomic analysis of JAK2 and of other JAK - STAT pathway members may lead to the identification of mutations of the JAK - STAT pathway in lymphoid diseases and other malignancies.

The incidence of the lymphoid cancers is rising faster than any other common cancer seen in North America.

The form of polydactyly found in the hind limbs of this breed is similar to that observed in Alx - 4 knockout mice (18), and it has been shown that deletion of this PQn repeat (but not other portions of the protein) specifically destroys the ability of Alx - 4 to bind with lymphoid enhancer binding factor - 1 and drive target gene expression in limb bud mesenchyme (19).

The workshop will also discuss other well described syndromes such as Li - Fraumeni germline TP53 mutations as well as inherited lymphoid malignancies and pedigrees of high interest that have no known genetic predisposition alleles identified.

The glands may also become swollen because of infiltrates from other cancers including those of fat, lymphoid, mast and melanocyte cells.

However, not all lymphoid cancers are associated with infections, so other genetic and environmental factors are also important.

Lymphoid, plasmacytic, histiocytic and mast cell cancers may sometimes be diagnosed from bone marrow biopsy, but these usually have signs of cancer elsewhere and are diagnosed by biopsy of other sites.

Other, but rarer, causes of metastatic calcification include kidney disease (this is the most common cause in cats), malignant tumors producing abnormal hormones that increase blood calcium concentrations (e.g. tumors of the lymphoid system and glands of the anal sac), diabetes mellitus and lung disease.

Chronic lymphoid leukemia impairs the bone marrow and results in the under production of other blood cells that are required for combating inflammations, allergies and infections.

About 10 % of these lymphoid tumors induce other clinical signs that are not readily explained by spread of the tumors.