Sentences with phrase «other measures of risk»

If that were to happen, we would need S&P strength to be confirmed by other action, particularly other measures of risk - premiums.

Not exact matches

On the other hand, first - time advertisers are at risk for spending a lot of precious capital for exposure they are unprepared to measure and leverage.

The cars» software can recognize cyclists» hand signals and is programmed to give bicycles a wide berth when the car is passing them, among other measures to minimize the risk of a collision.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

Political risk consulting company Eurasia Group says that other measures the Trump administration may soon roll out could include blocking Chinese cloud services companies from establishing data centres in the U.S.; a renewed emphasis on restricting sales of Chinese telecommunications equipment to major U.S. operators; and prohibiting Chinese acquisitions of U.S. firms in sectors such as artificial intelligence, automation, robotics, semiconductors and biotechnology.

«On the other hand, using the same essential measures of valuation and market action, but including periods of major economic dislocation into the dataset, produces average return / risk inferences that are substantially less favorable.

On the other hand, it is important to note that the spread between earnings price ratios and real interest rates are at near record levels, and that is a crude measure of the equity risk premium.

So determining systemic risk may be largely a matter of size, at least to the extent that G - SIB scores are an accurate measure, but that doesn't mean it's safe to ignore the other indicators.

Otherwise the EU will lose credibility and runs the risk of other countries calling WTO rules into question with protectionist measures.

That still leaves one - fifth of the systemic risk score accounted for by other measures, but perhaps the answer is not quite so simple.

As usual, I don't place too much emphasis on this sort of forecast, but to the extent that I make any comments at all about the outlook for 2006, the bottom line is this: 1) we can't rule out modest potential for stock appreciation, which would require the maintenance or expansion of already high price / peak earnings multiples; 2) we also should recognize an uncomfortably large potential for market losses, particularly given that the current bull market has now outlived the median and average bull, yet at higher valuations than most bulls have achieved, a flat yield curve with rising interest rate pressures, an extended period of internal divergence as measured by breadth and other market action, and complacency at best and excessive bullishness at worst, as measured by various sentiment indicators; 3) there is a moderate but still not compelling risk of an oncoming recession, which would become more of a factor if we observe a substantial widening of credit spreads and weakness in the ISM Purchasing Managers Index in the months ahead, and; 4) there remains substantial potential for U.S. dollar weakness coupled with «unexpectedly» persistent inflation pressures, particularly if we do observe economic weakness.

APRA chairman Wayne Byres said the report should provide important insights for all financial institutions «about the need to maintain a broad focus on all aspects of risk and stakeholder interest and not allow financial success to mask or detract from other important measures of an institution's performance and risk profile».

This is why any willingness to accept risk will far more tied to our longstanding measures of market action and other testable factors than to some novel «Bernanke faith factor» that we have no way of testing historically in any kind of rigorous manner.

However, the risk of being thrown off the scent can be reduced by having an objective way of measuring the ebbs and flows in the confidence that drives, among other things, the performance of the gold market.

In other words, we add one of the five risk - free assets to the following base set of eight ETFs and measure effects on the Top 1, equally weighted (EW) Top 2 and EW Top 3 SACEMS portfolios:

The 1998 and 2005 AAP policy statements and the Back to Sleep campaign not only addressed the importance of back sleeping but also provided recommendations for other infant care practices that may reduce the risk of SIDS and other sleep - related infant deaths.1, 9 Unfortunately, the ability to measure the prevalence of these other risk factors is limited by lack of data.

Companies should comply with composition and labelling requirements and other marketing requirements to reduce risks — independently of government measures.

Companies should comply with composition and labelling requirements and other Code requirements to reduce risks — independently of government measures.

The good news is that recent studies are revealing that when all doesn't go as planned, positive impacts can be made on baby's flora and intestinal health with the use of probiotics and other healing measures, thereby reducing later risks of many chronic diseases.

(1) in collaboration with FAO, and taking into account the work undertaken by the Codex Alimentarius Commission, to develop guidelines for clinicians and other health - care providers, community health workers and family, parents and other caregivers on the preparation, use, handling and storage of infant formula so as to minimize risk, and to address the particular needs of Member States in establishing effective measures to minimize risk in situations where infants can not be, or are not, fed breast milk;

Evidence shows that the most effective policies to reduce alcohol harms, including harms to others, are: - Raising the price of the cheapest alcohol, through taxation and minimum unit pricing - Regulating the density of outlets that can serve alcohol and restricting the permitted hours of sale - drink driving laws, including a lower legal blood alcohol limit and random roadside breath tests - Screening and brief advice for people who are at risk of drinking to a level that is harmful to themselves and others However, the most effective approach is a comprehensive, multi-sectorial set of measures that work together to reduce levels of harmful drinking.

Under the proposed measure, family members or law enforcement could petition a court for «Extreme Risk Protection Orders,» which, if granted, would allow officers to temporarily confiscate firearms and prevent the purchase of additional weapons by those deemed at risk of causing harm to themselves or othRisk Protection Orders,» which, if granted, would allow officers to temporarily confiscate firearms and prevent the purchase of additional weapons by those deemed at risk of causing harm to themselves or othrisk of causing harm to themselves or others.

Although most of the Senate's Republican majority opposed it, Saland and three others voted for the measure, risking their careers in what they said were personal votes of conscience.

He is planning to conduct a prescribed exercise intervention in a population of healthy older adults with genetic and other risk factors for Alzheimer's disease and to measure the impact on hippocampal volume and brain function.

They also note that Aedes mosquitoes also spread dengue and chikungunya, two other notorious tropical diseases, so the model effectively measures risks of all three diseases rather than any one of them alone.

Although the results from the models can not yet give definite measures of the probability of a flood, they do provide an insight into how those risks have changed and continue to change — information that is of great interest to insurance underwriters, among others.

Other measures such as cognitive (i.e. IQ) ability, early linguistic skills, measures of the environment such as socio - economic status, and whether there is a family member with reading problems or dyslexia are all common early factors used to assess risk of developing reading difficulties.

Although the prevalence of diabetes mellitus increased over time, other risk factors, such as cigarette smoking, measured systolic blood pressure, and total cholesterol values, decreased.

There are a range of interventions for pregnant woman that can reduce the risk of preterm birth, if identified early, which include steroid injections that strengthen the lungs of the fetus, and preventive measures by the mother such as optimizing nutrition and other lifestyle changes.

Other risk factors for diabetes included AHI during rapid eye movement sleep and measures of the physiologic consequences of OSA, including oxygen desaturation, sleep deprivation and activation of the sympathetic nervous system, as indicated by a higher mean heart rate during sleep.

As a next step, Bradshaw, De Jager and their colleagues plan to measure CD33 and TREM2 levels in subjects as part of the Brigham Healthy Aging Project to determine if these measurements and others could be part of a diagnostic panel for predicting risk of Alzheimer's disease.

In terms of other adiposity measures, the less fat, especially around their abdomen, they have, the lower the risk of future heart disease.»

The other adiposity measures show that the leaner the person the lower the risk of CVD, and this must be a public message, that healthy individuals should maintain a lean physique to minimise their risk of CVD,» concluded Dr Iliodromiti.

The deCODE BreastCancer ™ test measures seven widely replicated single - letter variations (SNPs) in the human genome that deCODE and others have linked to risk of breast cancer.

I have ordered several tests on an early - access basis and plan to make this test a standard tool for helping me to decide which of my patients may benefit from screening at an earlier age, breast MRIs, and other risk reduction measures.

«Identification of genes that contribute to Alzheimer's risk and that influence the progression of disease will help lead us to the cause of the disease, identify proteins and other new targets for drug development, and provide genetic methods for determining which people are at greatest risk for Alzheimer's disease when preventative measures become available,» said Dr. Schellenberg.

Identification of genes that contribute to Alzheimer's disease risk and that influence other characteristics of Alzheimer's disease will reveal basic pathogenic mechanisms, identify proteins and pathways for drug development, and provide genetic methods for determining people at greatest risk for when preventative measures become available.

But when measured in addition to our TCF7L2 variant that is the anchor of the deCODE T2 ™ test, it may, like other common variants conferring modest risk, enable the test to capture an even larger proportion of inherited risk.

Other factors leading to the decline could include improved preventive measures and changes in the incidence of unknown risk factors, Jemal said.

Researchers also gauged the participants» risk of heart disease (by measuring cholesterol, blood pressure, and other risk factors) and their levels of depression, hostility, and anxiety.

Another study examining the effects the different lipids in terms of heart disease risk found that «triglyceride concentration was not independently related with CHD risk after controlling for HDL - C, non — HDL - C, and other standard risk factors, including null findings in women and under nonfasting conditions.21, 22 Hence, for population - wide assessment of vascular risk, triglyceride measurement provides no additional information about vascular risk given knowledge of HDL - C and total cholesterol levels, although there may be separate reasons to measure triglyceride concentration (eg, prevention of pancreatitis).»

Before and after, the researchers measured inflammatory markers and other markers predictive of future disease risk, especially heart disease.

«When you introduce change to a complex system you need to measure all outputs otherwise you run the risk of helping one measure and harming others.

While they are less likely to diet or take other measures to lose weight than young women, those who do are at a greater risk of negative health impacts, like bone and muscle loss, kidney failure, and even death.

These measures have other health benefits, such as lowering your risk of cardiovascular disease and improving your overall mental health.

Although our primary exposures of interest were GI and glycemic load as risk factors for depression, we also investigated other measures of carbohydrate consumption computed from average daily intakes of foods and beverages reported on the WHI FFQ, including dietary added sugar, total sugars, specific types of sugars (glucose, sucrose, lactose, fructose), starch, and total carbohydrate.

If used as directed with other sun protection measures, descreases the risk of skin cancer and early skin aging caused by the sun.

To decrease this risk, regularly use a sunscreen with Broad Spectrum SPF value of 15 or higher and other sun protection measures, including: limit time in the sun, especially from 10a.

The researchers recently released two independent studies: One expands the common characteristics of a dropout, and the other offers an alternate method of measuring dropouts and tracking those at high risk of dropping out by computer throughout their school careers.

It is a smart system that recommends the use of other measures for individuals at risk, such as CBMreading for students who demonstrate risk on AUTOreading.