Sentences with phrase «other mechanisms of action»

Specifically, Ms. functioning should Lowell's current dissertation project aims have the capacity to to examine early childhood adversity and other mechanisms of action in the understand their own prediction of child maltreatment potential emotions, regulate those in substance - involved mothers.

Our two primary product candidates, CMB305 and G100, utilize distinct immuno - oncology approaches that, we believe, address the shortcomings of existing therapies and have the potential to treat a broad patient population either as individual therapies or in combination with other mechanisms of action.

Our product candidates are also intended to combine with other mechanisms of action across the oncology landscape, such as checkpoint inhibitors or engineered T cells, to increase the benefit to patients and potentially place Immune Design at a central place in the treatment paradigm.

We leverage our cutting - edge platforms to produce product candidates and utilize distinct therapeutic approaches that, we believe, address the shortcomings of existing therapies and have the potential to treat a broad patient population either as individual therapies or in combination with other mechanisms of action.

Not exact matches

If through consumer boycotts and other mechanisms publishers and booksellers begin to feel the pinch, it is the pinch of democracy in action.

If, e.g., as sometimes happens, the man, after a time, more or less, recovers the faculties of which the injury to his brain had deprived him, and that not in consequence of a renewal of the injured part, but in consequence of the inhibited functions being performed by the vicarious action of other parts, the easiest explanation certainly is that, after a time, consciousness constitutes the remaining parts into a mechanism capable of acting as a substitute for the lost parts.

The CIP includes action areas for Member States, WHO and other actors and recommends «to create a supportive environment for the implementation of comprehensive food and nutrition policies» and calls for Member States to «establish a dialogue with relevant national and international parties and form alliances and partnerships to expand nutrition actions with the establishment of adequate mechanisms to safeguard against potential conflicts of interest».

But other political observers saw in the announcement a chance for Cuomo to boost his profile in several national debates — possibly in advance of a presidential run in 2016 — as well as a convenient mechanism to take unlimited contributions for ads that, while not explicitly urging people to vote for Cuomo or anybody else, present a glowing portrayal of his actions.

The underlying mechanism might be related to the concept of «social priming,» where people's actions towards others are altered subconsciously due to exposure to particular words, cues, objects, or symbols.

The team is also testing the resolution of the microfluidic system with other reagents and materials, bringing researchers one step closer to viewing live biological mechanisms in action at the highest levels of resolution possible.

Jordi Mestres, coordinator of the IMIM and UPF research group on Systems Pharmacology at the Biomedical Informatics Program (GRIB) states «With this study we have contributed to complementing the detection of these quite unstable fragments, with information on the mechanism of action of the drug, based on three aspects: similarity to other medicines, prediction of their pharmacological profile, and interference with specific biological pathways.

However, there are other measures, potentially related to why baclofen might work (i.e. its mechanism of action).

Future research will aim to describe the precise molecular mechanisms of action, as well as to generate other orthologs that boost efficacy while reducing side effects.

Celecoxib has a similar mechanism of action to other well - known anti-inflammatory drugs you might take for a headache, such as aspirin and ibuprofen, and doctors commonly prescribe it for pain relief.

Coibamide A showed a pattern of activity unmatched by any other compound, suggesting it might be able to fight cancer through a mechanism of action unlike that of any existing drug.

Thus, astrocytic insulin signaling plays an important role in dopaminergic signaling, providing a potential mechanism by which astrocytic insulin action may contribute to increased rates of depression in people with diabetes, obesity and other insulin resistant states.

«The fact that the mechanism of action involves the p38 MAPK enzyme is fortuitous because drugs to combat that pathway are being tested for other diseases.

The channel - like property could have evolved, says Edwards, to meet the important need of moving large amounts of glutamate quickly, for while the other neurotransmitters are involved in modulating behaviors, such as mood, and therefore don't need to act with millisecond speed, glutamate functions by rapid - fire communication between closely placed nerve cells, and could require the fast action of the channel mechanism.

Twenty - two years passed before the structures of these proteins were established; the significance of the work is that it provided the basis for an understanding of the mechanism of the action of enzymes and other proteins, an active and fruitful subject of modern investigation.

Because of its novel mechanism of action, AST - OPC1 could also potentially benefit patients with other neurological disorders associated with de-myelination, such as multiple sclerosis and white matter stroke.

We are developing cutting - edge discovery platforms and product strategies for effective cancer immunotherapies that we believe take into consideration the limitations of other approaches, as well as leveraging different mechanisms of action to address the risk of reliance on a single approach.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

In each instance, we collaborate with other labs and attempt to use structures to understand the molecular mechanism of enzymatic action and the interaction between a protein and its inhibitors.

Other studies in the laboratory focus on the molecular mechanisms underlying HIV latency, including a role for host proteins and miRNAs that reinforce the latent state as well as the action of host proteins such as NF - kB that antagonize latency.

Stelara gives hope to hard - to - treat patients like Navani, and because it has a different mechanism of action, its especially promising for patients who havent responded, or have stopped responding, to other biologics.

One of Stelaras main selling points is that it has a different mechanism of action than the other biologics on the market.

The mechanism of the action and the role of alcohol or other elements of alcoholic beverages in connection with alcohol - induced headache was reviewed.

The mechanism of action may also be slightly different than that of other TNF inhibitors, he adds.

All the other biochemical, physiological and psychological effects of caffeine come as a result of this primary mechanism of action.

For those suffering from lead or other heavy metal poisoning, a protective diet that avoids processed foods and emphasizes the central components of a nutrient - dense and antioxidant - rich WAPF - style diet is essential (see sidebar).21 Nutritional status shapes susceptibility to lead toxicity in important ways, affecting lead's intestinal absorption; its mobilization, distribution and retention in the body; and excretion.22 Because oxidative stress is a likely mechanism explaining some of lead's toxic actions, some investigators have begun to explore whether natural antioxidants and trace minerals may help mitigate lead - induced cell damage.17 Specifically, researchers in Spain found that administration of vitamins A, B6, C and E along with zinc modulated some of the negative effects of lead exposure in rat pups, confirming the influence of nutritional factors on health outcomes following lead exposure.17 Vitamin D also should be a major component of a protective diet.

FAA has a variety of enforcement mechanisms that it may use to respond to violations including administrative actions (such as issuing a warning notice or a letter of correction that includes the corrective actions the violator must take) and legal sanctions (such as levying a fine or suspending or revoking a pilot or other FAA - issued certificate).

Acetaminophen is different from other NSAIDs in its mechanism of action.

Unlike other pain relievers, acetaminophen does not block the production of prostaglandins to reduce pain and fever — the exact mechanism of action of acetaminophen is not well known.

In this post we shall take a closer look at this particular product and learn more of its mechanism of action and why many vets and pet owners alike actually recommend this product over other brands.

The mechanism of action of Simplicef (Cefpodoxime) is similar to other cephalosphorins except that its antibacterial spectrum occurs on a much broader scale.

Changed the method for rendering the world from Item Frames (1.8.x) to diamond hoe damage values (1.9.x) Added collision detection Added walking animations New control mechanism - select hotbar slot, then right click to run action (allows single pushes and button holding) Converted the Pokédex and other static menu items from maps to textures Results: Significantly reduced file size, elimination of ~ 25,000 command blocks (mostly from the Pokédex), more responsive controls

Among a suite of recommendations to ramp up climate action, it proposes «a voluntary market or other mechanisms» to incentivize «earth - friendly agriculture.»

The new AWG - LCA 8, item 3 on nationally - appropriate mitigation actions (NAMAs) by developing country parties released this morning creates either a registry as part of the financial mechanism or some other mechanism to record NAMAs from developing countries, specifying only NAMAs seeking or receiving support would be required for verification through an international mechanism or registry.

Because JAMS provides alternative dispute resolution mechanisms that operate in accordance with judicial procedures, we may also deny or limit access to personal data in the following contexts: (i) interference with law enforcement or with private causes of action, including the prevention, investigation or detection of offenses or the right to a fair trial, arbitration or mediation; (ii) disclosure where the legitimate rights or important interests of others would be violated; (iii) breaching a legal or other professional privilege or obligation; (iv) prejudicing employee security investigations or grievance proceedings or in connection with employee succession planning and corporate reorganizations; or (v) prejudicing the confidentiality necessary in monitoring, inspection or regulatory functions connected with sound management, or in future or ongoing negotiations involving JAMS.

While accepting that the opt - out process can be a mechanism for parties to express disapproval of the class action or to pursue other methods of problem - solving, [18] Justice Strathy emphasized that the opt - out process in a class proceeding must be fair and free of coercion.

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on Collisions And How To Avoid Them Headlights How Speed Affects Impact Illness Affects Driving Abilities Implied Consent and Zero Tolerance and Open Container Laws Kids Left In Cars Left - foot Braking Legal Requirements Of Seat - belts In Texas Legalities of BAC Light Conditions and your headlights Littering Laws In Texas Motorcycles Laws and Rules In Texas Myths And Misconceptions of Drinking and Driving No Insurance Or Lose Your License Off - road Skid Recovery Techniques Organ Donation — What You Need To Know Passing On A Two - Lane Road Pedestrians Right - of - way Laws In Texas Personality Type Affects Your Driving Physiological Effects Of Driving Intoxicated Picking The Right Vehicle For You Proper Driving Position And Its importance To You Railroad Crossing Laws In Texas Rain — How To Drive In It Rear - end And Side Impact Collision And How To Avoid Them Road Conditions — What You Should Do When They Change Scene Of A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - up For The Texas online course Think Before You Drink And Drive Tire Maintenance — How To Maintain Your Cars Tires Tire Pressure Trucks — How To Share The Road with Semi-Trucks Using Your Cars Mirors Walk Around Inspection On Your Car Wind — How To Drive In Heavy Wind Yield — Its a Matter Of Courtesy Yielding To The Traffic On The FreewOf Seat - belts In Texas Legalities of BAC Light Conditions and your headlights Littering Laws In Texas Motorcycles Laws and Rules In Texas Myths And Misconceptions of Drinking and Driving No Insurance Or Lose Your License Off - road Skid Recovery Techniques Organ Donation — What You Need To Know Passing On A Two - Lane Road Pedestrians Right - of - way Laws In Texas Personality Type Affects Your Driving Physiological Effects Of Driving Intoxicated Picking The Right Vehicle For You Proper Driving Position And Its importance To You Railroad Crossing Laws In Texas Rain — How To Drive In It Rear - end And Side Impact Collision And How To Avoid Them Road Conditions — What You Should Do When They Change Scene Of A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - up For The Texas online course Think Before You Drink And Drive Tire Maintenance — How To Maintain Your Cars Tires Tire Pressure Trucks — How To Share The Road with Semi-Trucks Using Your Cars Mirors Walk Around Inspection On Your Car Wind — How To Drive In Heavy Wind Yield — Its a Matter Of Courtesy Yielding To The Traffic On The Freewof BAC Light Conditions and your headlights Littering Laws In Texas Motorcycles Laws and Rules In Texas Myths And Misconceptions of Drinking and Driving No Insurance Or Lose Your License Off - road Skid Recovery Techniques Organ Donation — What You Need To Know Passing On A Two - Lane Road Pedestrians Right - of - way Laws In Texas Personality Type Affects Your Driving Physiological Effects Of Driving Intoxicated Picking The Right Vehicle For You Proper Driving Position And Its importance To You Railroad Crossing Laws In Texas Rain — How To Drive In It Rear - end And Side Impact Collision And How To Avoid Them Road Conditions — What You Should Do When They Change Scene Of A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - up For The Texas online course Think Before You Drink And Drive Tire Maintenance — How To Maintain Your Cars Tires Tire Pressure Trucks — How To Share The Road with Semi-Trucks Using Your Cars Mirors Walk Around Inspection On Your Car Wind — How To Drive In Heavy Wind Yield — Its a Matter Of Courtesy Yielding To The Traffic On The Freewof Drinking and Driving No Insurance Or Lose Your License Off - road Skid Recovery Techniques Organ Donation — What You Need To Know Passing On A Two - Lane Road Pedestrians Right - of - way Laws In Texas Personality Type Affects Your Driving Physiological Effects Of Driving Intoxicated Picking The Right Vehicle For You Proper Driving Position And Its importance To You Railroad Crossing Laws In Texas Rain — How To Drive In It Rear - end And Side Impact Collision And How To Avoid Them Road Conditions — What You Should Do When They Change Scene Of A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - up For The Texas online course Think Before You Drink And Drive Tire Maintenance — How To Maintain Your Cars Tires Tire Pressure Trucks — How To Share The Road with Semi-Trucks Using Your Cars Mirors Walk Around Inspection On Your Car Wind — How To Drive In Heavy Wind Yield — Its a Matter Of Courtesy Yielding To The Traffic On The Freewof - way Laws In Texas Personality Type Affects Your Driving Physiological Effects Of Driving Intoxicated Picking The Right Vehicle For You Proper Driving Position And Its importance To You Railroad Crossing Laws In Texas Rain — How To Drive In It Rear - end And Side Impact Collision And How To Avoid Them Road Conditions — What You Should Do When They Change Scene Of A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - up For The Texas online course Think Before You Drink And Drive Tire Maintenance — How To Maintain Your Cars Tires Tire Pressure Trucks — How To Share The Road with Semi-Trucks Using Your Cars Mirors Walk Around Inspection On Your Car Wind — How To Drive In Heavy Wind Yield — Its a Matter Of Courtesy Yielding To The Traffic On The FreewOf Driving Intoxicated Picking The Right Vehicle For You Proper Driving Position And Its importance To You Railroad Crossing Laws In Texas Rain — How To Drive In It Rear - end And Side Impact Collision And How To Avoid Them Road Conditions — What You Should Do When They Change Scene Of A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - up For The Texas online course Think Before You Drink And Drive Tire Maintenance — How To Maintain Your Cars Tires Tire Pressure Trucks — How To Share The Road with Semi-Trucks Using Your Cars Mirors Walk Around Inspection On Your Car Wind — How To Drive In Heavy Wind Yield — Its a Matter Of Courtesy Yielding To The Traffic On The FreewOf A Traffic Crash School Bus Passing Laws In Texas Seat Belts — How To Properly Use Them Signs — Signals And Markings In Texas Snow And Ice Driving Tips Speed Limits Laws In Texas Steering Mechanism On Your Car Strategies For Driving In Traffic Stress And How It Affects Your Driving Behavior The Reasons For Car Crashes Traffic Safety Problems In Texas The Wrap - 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Apple faces its first legal action over Meltdown and Spectre in the United States, even though the vulnerabilities were found to affect nearly all computers and other devices, according to court documents reviewed by MacRumors.Meltdown and Spectre are serious hardware - based vulnerabilities that take advantage of the speculative execution mechanism of a CPU, allowing hackers to gain access to sensitive information.

About Youtuber Welcome to CAST PHARMA «s YouTube channel, featuring various inspiring showreels, memorable medical case studies of mechanism of action animations, scientific posters, animated PowerPoint presentations, interactive applications and other visual stories for pharmaceutical marketing and marketing in the healthcare and life sciences industry.

This work has also been extended to specialized designs and analyses for evaluating mechanisms of action and other mediation effects.

Doing so allows the members of the couple to understand and depersonalize their actions in relationship with each other, based on an understanding of their attachment orientation and arousal regulation mechanisms.

This study (NIDA #R01 DA041425 - 01) will evaluate the effectiveness of comprehensive treatment for justice - involved emerging adults with alcohol and other drug (AOD) abuse, as well as examining the mechanism of action for such treatments.